Journal ArticleDOI
IgG4-related disease: nomenclature, clinical features, and treatment.
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TLDR
The current thought and understanding of this disease with regard to nomenclature, organ system involvement, and approaches to therapy are reviewed.Citations
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Journal ArticleDOI
The diagnostic utility of serum IgG4 concentrations in IgG4-related disease
TL;DR: Multiple non-IgG4-RD conditions are associated with elevated serum IgG4, leading to poor specificity and low positive predictive value for this test, while a substantial subset of patients with biopsy-proven IgG 4-RD do not have elevated serum igG4.
Journal ArticleDOI
The clinical spectrum of IgG4-related disease
TL;DR: Presenting features of IgG4-RD vary substantially according to the specialty to which patients present first; in addition, the disease can be diagnosed unexpectedly in pathological specimens or identified incidentally on radiology studies.
Journal ArticleDOI
Clinical characteristics of immunoglobulin G4–related disease: a prospective study of 118 Chinese patients
Wei Lin,Sha Lu,Hua Chen,Qingjun Wu,Yunyun Fei,Mengtao Li,Xuan Zhang,Xinping Tian,Wenjie Zheng,Xiaomei Leng,Dong Xu,Qian Wang,Min Shen,Li Wang,Jing Li,Di Wu,Lidan Zhao,Chanyuan Wu,Yunjiao Yang,Linyi Peng,Jiaxin Zhou,Yu Wang,Yue Sha,Xiaoming Huang,Yang Jiao,Xuejun Zeng,Qun Shi,Ping Li,Shulan Zhang,Chaojun Hu,Chuiwen Deng,Yongzhe Li,Shangzhu Zhang,Jinjing Liu,Jinmei Su,Yong Hou,Ying Jiang,Xin You,Haiting Zhang,Linyi Yan,Wen Zhang,Yan Zhao,Xiaofeng Zeng,Fengchun Zhang,Peter E. Lipsky +44 more
TL;DR: IgG4-RD is a systemic inflammatory and sclerosing disease that shows favourable responses to treatment with glucocorticoids and immunosuppressive agents, and the majority usually improved within 3 months.
Journal ArticleDOI
Diagnostic Approach to the Complexity of IgG4-Related Disease.
TL;DR: Most recent knowledge about the clinical, laboratory, radiological, and pathological characteristics of IgG4-RD that may guide the physician to establish an early diagnosis are provided.
Journal ArticleDOI
Brief Report: spuriously low serum IgG4 concentrations caused by the prozone phenomenon in patients with IgG4-related disease.
Arezou Khosroshahi,Lynn A. Cheryk,Mollie N. Carruthers,Judith A. Edwards,Daniel Bloch,John H. Stone +5 more
TL;DR: To determine the frequency of the prozone effect in patients with IgG4-related disease (IgG4‐RD), data are analyzed through positron emission tomography and radiolysis to establish a stationary phase for prozone modulation.
References
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Journal ArticleDOI
Case records of the Massachusetts General Hospital.
Journal ArticleDOI
High serum IgG4 concentrations in patients with sclerosing pancreatitis.
Hideaki Hamano,Shigeyuki Kawa,Akira Horiuchi,Hiroshi Unno,Naoyuki Furuya,Taiji Akamatsu,Mana Fukushima,Toshio Nikaido,Kohzo Nakayama,Nobuteru Usuda,Kendo Kiyosawa +10 more
TL;DR: Patients with sclerosing pancreatitis have high serum IgG4 concentrations, providing a useful means of distinguishing this disorder from other diseases of the pancreas or biliary tract.
Journal ArticleDOI
Consensus statement on the pathology of IgG4-related disease
Vikram Deshpande,Yoh Zen,John Kc Chan,Eunhee E Yi,Yasuharu Sato,Tadashi Yoshino,Günter Klöppel,J. Godfrey Heathcote,Arezou Khosroshahi,Judith A. Ferry,Rob C. Aalberse,Daniel Bloch,William R. Brugge,Adrian C Bateman,Mollie N. Carruthers,Suresh T. Chari,Wah Cheuk,Lynn D. Cornell,Carlos Fernandez-del Castillo,David G. Forcione,Daniel L. Hamilos,Terumi Kamisawa,Satomi Kasashima,Shigeyuki Kawa,Mitsuhiro Kawano,Gregory Y. Lauwers,Yasufumi Masaki,Yasuni Nakanuma,Kenji Notohara,Kazuichi Okazaki,Ji Kon Ryu,Takako Saeki,Dushyant V. Sahani,Thomas C. Smyrk,James Robert Stone,Masayuki Takahira,George Webster,Motohisa Yamamoto,Giuseppe Zamboni,Hisanori Umehara,John H. Stone +40 more
TL;DR: This statement proposes a terminology scheme for the diagnosis of IgG4-related disease that is based primarily on the morphological appearance on biopsy, and advocates the use of strict criteria for accepting newly proposed entities or sites as components of the IgG 4- related disease spectrum.
Journal ArticleDOI
M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.
Laurence H. Beck,Ramon G. Bonegio,Gérard Lambeau,David M. Beck,David W. Powell,Timothy D. Cummins,Jon B. Klein,David J. Salant +7 more
TL;DR: A majority of patients with idiopathic membranous nephropathy have antibodies against a conformation-dependent epitope in PLA(2)R, indicating that PLA( 2)R is a major antigen in this disease.
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Consensus statement on the pathology of IgG4-related disease
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