H
Hua Chen
Researcher at Peking Union Medical College Hospital
Publications - 138
Citations - 11456
Hua Chen is an academic researcher from Peking Union Medical College Hospital. The author has contributed to research in topics: Kidney disease & Medicine. The author has an hindex of 39, co-authored 122 publications receiving 8586 citations. Previous affiliations of Hua Chen include Peking Union Medical College & Chinese Ministry of Education.
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Journal ArticleDOI
A metagenome-wide association study of gut microbiota in type 2 diabetes
Junjie Qin,Yingrui Li,Zhiming Cai,Shenghui Li,Jianfeng Zhu,Fan Zhang,Suisha Liang,Wenwei Zhang,Yuanlin Guan,Dongqian Shen,Yangqing Peng,Dongya Zhang,Zhuye Jie,Wenxian Wu,Youwen Qin,Wenbin Xue,Junhua Li,Lingchuan Han,Donghui Lu,Peixian Wu,Yali Dai,Xiaojuan Sun,Zesong Li,Aifa Tang,Shilong Zhong,Xiaoping Li,Weineng Chen,Ran Xu,Mingbang Wang,Qiang Feng,Meihua Gong,Jing Yu,Yanyan Zhang,Ming Zhang,Torben Hansen,Gaston Sanchez,Jeroen Raes,Gwen Falony,Shujiro Okuda,Mathieu Almeida,Emmanuelle Le-chatelier,Pierre Renault,Nicolas Pons,Jean-Michel Batto,Zhaoxi Zhang,Hua Chen,Ruifu Yang,Wei-Mou Zheng,Songgang Li,Huanming Yang,Jian Wang,S. Dusko Ehrlich,Rasmus Nielsen,Oluf Pedersen,Oluf Pedersen,Karsten Kristiansen,Jun Wang +56 more
TL;DR: MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance.
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The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment
Xuan Zhang,Dongya Zhang,Huijue Jia,Qiang Feng,Donghui Wang,Di Liang,Xiangni Wu,Junhua Li,Longqing Tang,Yin Li,Zhou Lan,Bing Chen,Yanli Li,Huanzi Zhong,Hailiang Xie,Zhuye Jie,Weineng Chen,Shanmei Tang,Xiaoqiang Xu,Xiaokai Wang,Xianghang Cai,Liu Sheng,Yan Xia,Jiyang Li,Xingye Qiao,Jumana Y. Al-Aama,Hua Chen,Li Wang,Qingjun Wu,Fengchun Zhang,Wenjie Zheng,Yongzhe Li,Mingrong Zhang,Guangwen Luo,Wenbin Xue,Liang Xiao,Jun Li,Wanting Chen,Xun Xu,Ye Yin,Huanming Yang,Jian Wang,Karsten Kristiansen,Liang Liu,Ting Li,Qingchun Huang,Yingrui Li,Jun Wang +47 more
TL;DR: Altered alterations in the gut, dental or saliva microbiome distinguished individuals with RA from healthy controls, were correlated with clinical measures and could be used to stratify individuals on the basis of their response to therapy.
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Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment
Lin Chen,Tian Yang,De-Wen Lu,Hui Zhao,Ya-Long Feng,Hua Chen,Dan-Qian Chen,Nosratola D. Vaziri,Ying-Yong Zhao +8 more
TL;DR: TGF-β/Smad signaling is an important pathway that mediates renal fibrosis and inflammation and an effective target of anti-fibrotic therapies for treatment of CKD.
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Characterizing IgG4-related disease with 18F-FDG PET/CT: a prospective cohort study
Jingjing Zhang,Hua Chen,Yanru Ma,Yu Xiao,Na Niu,Wei Lin,Xinwei Wang,Zhiyong Liang,Fengchun Zhang,Fang Li,Wen Zhang,Zhaohui Zhu +11 more
TL;DR: F-FDG PET/CT is a useful tool for assessing organ involvement, monitoring therapeutic response, and guiding interventional treatment of IgG4-RD, and the image pattern is suggested to be updated into the consensus diagnostic criteria for IgG 4-RD.
Journal ArticleDOI
MOCAT: A Metagenomics Assembly and Gene Prediction Toolkit
Jens Roat Kultima,Shinichi Sunagawa,Junhua Li,Weineng Chen,Hua Chen,Daniel R. Mende,Manimozhiyan Arumugam,Qi Pan,Binghang Liu,Junjie Qin,Jun Wang,Peer Bork +11 more
TL;DR: MOCAT is a highly configurable, modular pipeline for fast, standardized processing of single or paired-end sequencing data generated by the Illumina platform that integrates seamlessly with the SGE and PBS queuing systems.