Impact of diabetes mellitus on ventricular structure, arterial stiffness, and pulsatile hemodynamics in heart failure with preserved ejection fraction
Julio A. Chirinos,Julio A. Chirinos,Julio A. Chirinos,Priyanka Bhattacharya,Anupam Kumar,Anupam Kumar,Elizabeth A. Proto,Prasad Konda,Patrick Segers,Scott Akers,Raymond R. Townsend,Raymond R. Townsend,Payman Zamani,Payman Zamani +13 more
TLDR
Diabetes mellitus is a key determinant of left ventricular remodeling, arterial stiffness, adverse pulsatile hemodynamics, and ventricular‐arterial interactions in HFpEF.Abstract:
Background Heterogeneity in the underlying processes that contribute to heart failure with preserved ejection fraction (HFpEF) is increasingly recognized. Diabetes mellitus is a frequent comorbidit...read more
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Journal ArticleDOI
Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review
TL;DR: An overview of key physiologic and biophysical principles related to arterial stiffness, the impact of aortic stiffening on target organs, noninvasive methods for the measurement of arterials stiffness, mechanisms leading to aorti stiffening, therapeutic approaches to reduce it, and clinical applications of arterial stiffening measurements is provided.
Journal ArticleDOI
Cellular and molecular pathobiology of heart failure with preserved ejection fraction.
Sumita Mishra,David A. Kass +1 more
TL;DR: A review of the cellular and molecular pathobiology of heart failure with preserved ejection fraction (HFpEF) can be found in this paper, with the major focus being on mechanisms relevant to the heart.
Journal Article
Arterial load and ventricular-arterial coupling: physiologic relations with body size and effect of obesity
Julio Chirinos Medina,Ernst Rietzschel,Marc De Buyzere,Dirk De Bacquer,Thierry C. Gillebert,Patrick Segers +5 more
TL;DR: In this article, the authors used non-linear regression to analyze a selected reference subsample (n=612) with normal weight (body mass index 18 −25 kg/m2), waist circumference and metabolic parameters.
Journal Article
Abstract 14934: Heart Failure, Left Ventricular Remodeling, and Circulating Nitric Oxide Metabolites
Julio A. Chirinos,Scott Akers,Lien Trieu,Harry Ischiropoulos,Paschalis-Thomas Doulias,Ali Tariq,Izzah Vassim,Maheswara R Koppula,Amer Ahmed Syed,Haideliza Soto-Calderon,Raymond R. Townsend,Thomas P. Cappola,Kenneth B. Margulies,Payman Zamani +13 more
TL;DR: HFpEF, but not HFrEF, is associated with reduced plasma NOM, suggesting greater endothelial dysfunction, enhanced clearance, or deficient dietary ingestion of inorganic nitrate may underlie the salutary effects of in organic nitrate supplementation demonstrated in recent clinical trials in HFpEF.
Journal ArticleDOI
Serum Albumin Is a Marker of Myocardial Fibrosis, Adverse Pulsatile Aortic Hemodynamics, and Prognosis in Heart Failure With Preserved Ejection Fraction
Stuart B. Prenner,Stuart B. Prenner,Raj Pillutla,Sowjanya Yenigalla,Sowmya Gaddam,Jonathan Lee,Jonathan Lee,Mary Jo Obeid,Armghan H Ans,Qasim Jehangir,Jessica Kim,Jessica Kim,Payman Zamani,Jeremy A. Mazurek,Scott Akers,Julio A. Chirinos,Julio A. Chirinos +16 more
TL;DR: Serum albumin is associated with myocardial fibrosis, adverse pulsatile aortic hemodynamics, and prognosis in HFpEF and is a strong predictor of death or heart failure hospitalization even after adjustment for N‐terminal pro B‐type natriuretic peptide levels and the MAGGIC risk score.
References
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TL;DR: Recommendations for the evaluation of left ventricular diastolic function by echocardiography are made and further research is needed to determine the best method for this evaluation.
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Recommendations for the evaluation of left ventricular diastolic function by echocardiography
Sherif F. Nagueh,Christopher P. Appleton,Thierry C. Gillebert,Paolo Marino,Jae K. Oh,Otto A. Smiseth,Alan D. Waggoner,Frank A. Flachskampf,Patricia A. Pellikka,Arturo Evangelisa +9 more
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Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking
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Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association
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