Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children
Joseph M. Braun,Amy E. Kalkbrenner,Antonia M. Calafat,Kimberly Yolton,Xiaoyun Ye,Kim N. Dietrich,Bruce P. Lanphear,Bruce P. Lanphear +7 more
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TLDR
G gestational BPA exposure affected behavioral and emotional regulation domains at 3 years of age, especially among girls, and Clinicians may advise concerned patients to reduce their exposure to certain consumer products, but the benefits of such reductions are unclear.Abstract:
To estimate the impact of gestational and childhood bis- phenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations. METHODS: We used a prospective birth cohort of 244 mothers and their 3-year-old children from the greater Cincinnati, Ohio, area. We characterized gestational and childhood BPA exposures by using the mean BPA concentrations in maternal (16 and 26 weeks of gestation and birth) and child (1, 2, and 3 years of age) urine samples, respec- tively. Behavior and executive function were measured by using the Behavior Assessment System for Children 2 (BASC-2) and the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P).read more
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Bisphenol A and human health: a review of the literature.
TL;DR: The growing human literature correlating environmental BPA exposure to adverse effects in humans, along with laboratory studies in many species including primates, provides increasing support that environmental B PA exposure can be harmful to humans, especially in regards to behavioral and other effects in children.
Journal ArticleDOI
EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals
Andrea C. Gore,Vesna A. Chappell,Suzanne E. Fenton,Jodi A. Flaws,Angel Nadal,Gail S. Prins,Jorma Toppari,R. T. Zoeller +7 more
TL;DR: A much more complete understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability, can be much better translated to human health.
Journal ArticleDOI
Neurobehavioural effects of developmental toxicity
TL;DR: To control the pandemic of developmental neurotoxicity, a global prevention strategy is proposed and chemicals in existing use and all new chemicals must therefore be tested for developmental neurotoxicants is proposed.
Journal ArticleDOI
A review of dietary and non-dietary exposure to bisphenol-A.
Tinne Geens,Dominique Aerts,Carl Berthot,Jean-Pierre Bourguignon,Leo Goeyens,Philippe Lecomte,Guy Maghuin-Rogister,Anne-Madeleine Pironnet,Luc Pussemier,Marie-Louise Scippo,Joris Van Loco,Adrian Covaci +11 more
TL;DR: The total exposure to BPA is several orders of magnitude lower than the current tolerable daily intake of 50 μg/kg bw/day, and the use of urinary concentrations from biomonitoring studies seems reliable for the overall exposure assessment.
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Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary
TL;DR: The CEF Panel concluded that there is no health concern for any age group from dietary exposure and low health concern from aggregated exposure, although considerable uncertainty in the exposure estimates for non-dietary sources was relatively low.
References
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