Journal ArticleDOI
Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer.
Harry W. Herr,Bernard H. Bochner,Guido Dalbagni,Sherri M. Donat,Victor E. Reuter,Dean F. Bajorin +5 more
TLDR
Surgical resection and pathological assessment of an adequate number of lymph nodes in cystectomy specimens increases the likelihood of proper staging and impacts patient outcome, and indicates that surgeons should study at least 9 lymph nodes to define lymph node status accurately.Abstract:
Purpose: We postulate that the number of lymph nodes examined in cystectomy specimens can have an impact on the outcome of patients with bladder cancer. Materials and Methods: We analyzed data on 322 patients with muscle invasive bladder cancer who underwent radical cystectomy and bilateral pelvic lymphadenectomy. We evaluated the associations of the number of lymph nodes identified by the pathologist in the surgical specimen with the local recurrence rate and survival outcome. Results: Patients were divided into groups by lymph node status and the distribution of the number of lymph nodes examined. In stages pN 0 and pN + cases improved survival was associated with a greater number of lymph nodes examined. We determined that at least nine lymph nodes should be studied to define lymph node status accurately. Conclusions: These results indicate that surgical resection and pathological assessment of an adequate number of lymph nodes in cystectomy specimens increases the likelihood of proper staging and impacts patient outcome. Such information is important not only for the therapy and prognosis of individuals, but also for identifying those who may benefit from adjuvant chemotherapy.read more
Citations
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Journal ArticleDOI
Treatment of muscle-invasive and metastatic bladder cancer: Update of the EAU guidelines
Arnulf Stenzl,Nigel C. Cowan,Maria De Santis,Markus A. Kuczyk,Axel S. Merseburger,Maria J. Ribal,Amir Sherif,J. Alfred Witjes +7 more
TL;DR: Current data demonstrate that neoadjuvant chemotherapy in conjunction with radical cystectomy (RC) is recommended in certain constellations of MiM-BC, and a new drug for second-line chemotherapy (vinflunine) in metastatic disease has been approved and is recommended.
Journal ArticleDOI
Treatment of Non-Metastatic Muscle-Invasive Bladder Cancer: AUA/ASCO/ASTRO/SUO Guideline.
Sam S. Chang,Bernard H. Bochner,Roger Chou,Robert Dreicer,Ashish M. Kamat,Seth P. Lerner,Yair Lotan,Joshua J. Meeks,Jeff M. Michalski,Todd M. Morgan,Diane Zipursky Quale,Jonathan E. Rosenberg,Anthony L. Zietman,Jeffrey M. Holzbeierlein +13 more
TL;DR: This guideline attempts to improve a clinician's ability to evaluate and treat each patient, but higher quality evidence in future trials will be essential to improve level of care for these patients.
Journal ArticleDOI
The Updated EAU Guidelines on Muscle-Invasive and Metastatic Bladder Cancer
Arnulf Stenzl,Nigel C. Cowan,Maria De Santis,Gerhard Jakse,M.A. Kuczyk,Axel S. Merseburger,Maria J. Ribal,Amir Sherif,J. Alfred Witjes +8 more
TL;DR: These EAU guidelines are a short, comprehensive overview of the updated guidelines of (MiM-BC) as recently published in theEAU guidelines and also available in the National Guideline Clearinghouse.
Journal ArticleDOI
Bladder cancer. Clinical practice guidelines in oncology.
Peter E. Clark,Neeraj Agarwal,Matthew C. Biagioli,Mario A. Eisenberger,Richard E. Greenberg,Harry W. Herr,Brant A. Inman,Deborah A. Kuban,Timothy M. Kuzel,Subodh M. Lele,Jeffrey M. Michalski,Lance C. Pagliaro,Sumanta K. Pal,Anthony Patterson,Elizabeth R. Plimack,Kamal S. Pohar,Michael P. Porter,Jerome P. Richie,Wade J. Sexton,William U. Shipley,Eric J. Small,Philippe E. Spiess,Donald L. Trump,Geoffrey Wile,Timothy G. Wilson,Mary A. Dwyer,Maria Ho +26 more
TL;DR: Experts believe that the treatment of urothelial tumors will evolve rapidly over the next few years, with improved outcomes for patients at all stages of disease.
Journal ArticleDOI
Radical cystectomy for invasive bladder cancer: long-term results of a standard procedure.
John P. Stein,Donald G. Skinner +1 more
TL;DR: The rationale and clinical results of large, contemporary cystectomy series are presented, which provide a benchmark of outcomes with this form of surgical treatment.
References
More filters
Journal ArticleDOI
Treatment of muscle-invasive and metastatic bladder cancer: Update of the EAU guidelines
Arnulf Stenzl,Nigel C. Cowan,Maria De Santis,Markus A. Kuczyk,Axel S. Merseburger,Maria J. Ribal,Amir Sherif,J. Alfred Witjes +7 more
TL;DR: Current data demonstrate that neoadjuvant chemotherapy in conjunction with radical cystectomy (RC) is recommended in certain constellations of MiM-BC, and a new drug for second-line chemotherapy (vinflunine) in metastatic disease has been approved and is recommended.
Journal ArticleDOI
Treatment of Non-Metastatic Muscle-Invasive Bladder Cancer: AUA/ASCO/ASTRO/SUO Guideline.
Sam S. Chang,Bernard H. Bochner,Roger Chou,Robert Dreicer,Ashish M. Kamat,Seth P. Lerner,Yair Lotan,Joshua J. Meeks,Jeff M. Michalski,Todd M. Morgan,Diane Zipursky Quale,Jonathan E. Rosenberg,Anthony L. Zietman,Jeffrey M. Holzbeierlein +13 more
TL;DR: This guideline attempts to improve a clinician's ability to evaluate and treat each patient, but higher quality evidence in future trials will be essential to improve level of care for these patients.
Journal ArticleDOI
The Updated EAU Guidelines on Muscle-Invasive and Metastatic Bladder Cancer
Arnulf Stenzl,Nigel C. Cowan,Maria De Santis,Gerhard Jakse,M.A. Kuczyk,Axel S. Merseburger,Maria J. Ribal,Amir Sherif,J. Alfred Witjes +8 more
TL;DR: These EAU guidelines are a short, comprehensive overview of the updated guidelines of (MiM-BC) as recently published in theEAU guidelines and also available in the National Guideline Clearinghouse.
Journal ArticleDOI
Bladder cancer. Clinical practice guidelines in oncology.
Peter E. Clark,Neeraj Agarwal,Matthew C. Biagioli,Mario A. Eisenberger,Richard E. Greenberg,Harry W. Herr,Brant A. Inman,Deborah A. Kuban,Timothy M. Kuzel,Subodh M. Lele,Jeffrey M. Michalski,Lance C. Pagliaro,Sumanta K. Pal,Anthony Patterson,Elizabeth R. Plimack,Kamal S. Pohar,Michael P. Porter,Jerome P. Richie,Wade J. Sexton,William U. Shipley,Eric J. Small,Philippe E. Spiess,Donald L. Trump,Geoffrey Wile,Timothy G. Wilson,Mary A. Dwyer,Maria Ho +26 more
TL;DR: Experts believe that the treatment of urothelial tumors will evolve rapidly over the next few years, with improved outcomes for patients at all stages of disease.
Journal ArticleDOI
Radical cystectomy for invasive bladder cancer: long-term results of a standard procedure.
John P. Stein,Donald G. Skinner +1 more
TL;DR: The rationale and clinical results of large, contemporary cystectomy series are presented, which provide a benchmark of outcomes with this form of surgical treatment.
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