Impaired responsiveness of homosexual men with HIV antibodies to plasma derived hepatitis B vaccine.
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TLDR
This study shows the impact that coincident HIV infection may have on an otherwise efficacious vaccine and the efficacy of this and other vaccines in patients infected with HIV needs to be studied urgently.Abstract:
Thirty five homosexual men (17 positive for antibody to the human immunodeficiency virus (HIV) and 18 consistently negative) were vaccinated against hepatitis B virus infection. Eight of the 17 seropositive patients failed to develop detectable hepatitis B surface antibody within three months of the third injection compared with only one of the 18 seronegative patients (p less than 0.01). HIV infection is prevalent in the developed world in groups at risk for hepatitis B infection and in certain Third World countries where widespread vaccination programmes exist. This study shows the impact that coincident HIV infection may have on an otherwise efficacious vaccine. The efficacy of this and other vaccines in patients infected with HIV needs to be studied urgently.read more
Citations
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Journal ArticleDOI
Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs.
Frank Miedema,A J Petit,F G Terpstra,J K Schattenkerk,F. De Wolf,B. J. M. Al,Marijke T. L. Roos,Johan Lange,Sven A. Danner,Jaap Goudsmit +9 more
TL;DR: HIV induces severe immunological abnormalities in T cells, B cells, and antigen-presenting cells early in infection before CD4+ T cell numbers start to decline, suggesting that impaired immunological function in subclinically HIV- infected patients may have clinical implications for vaccination strategies.
Journal ArticleDOI
Outcome of Hepatitis B Virus Infection in Homosexual Men and Its Relation to Prior Human Immunodeficiency Virus Infection
Stephen C. Hadler,Franklyn N. Judson,Paul M. O'Malley,Norman L. Altman,Kent A. Penley,Susan Buchbinder,Charles A. Schable,Patrick J. Coleman,David N. Ostrow,Donald R Francis +9 more
TL;DR: HIV-1 infection was associated with reduced alanine aminotransferase elevations during the first 36 months of follow-up of men who became HBV carriers, suggesting inactivated hepatitis B vaccine may temporarily impair the immune response to HBV infection in HIV-1-infected persons.
Journal ArticleDOI
Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B.
TL;DR: Because hepatitis B vaccination has a key role in the control of hepatitis B, properties of this vaccine, its effectiveness in pre-ex exposure and post-exposure settings, duration of protection after vaccination and the need of booster doses are discussed.
Journal ArticleDOI
Randomized trial of recombinant hepatitis B vaccine in HIV-infected adult patients comparing a standard dose to a double dose.
Marise Oliveira Fonseca,Lorrin Pang,Norma de Paula Cavalheiro,Antonio Alci Barone,Marta Heloísa Lopes +4 more
TL;DR: Based on the results of this study, the best current strategy for hepatitis B vaccination in HIV patients would be to use a double dose as a primary series when the viral load is likely to be low and CD4> or = 350, when there is probably to be an adequate immune response.
Journal ArticleDOI
Serologic Responses to Pneumocystis carinii Antigens in Health and Disease
S. L. Peglow,A. G. Smulian,A. G. Smulian,A. G. Smulian,M. J. Linke,M. J. Linke,M. J. Linke,C. L. Pogue,C. L. Pogue,C. L. Pogue,S. Nurre,S. Nurre,S. Nurre,J. Crisler,J. Crisler,J. Crisler,John P. Phair,J. W. M. Gold,J. W. M. Gold,J. W. M. Gold,D. Armstrong,D. Armstrong,D. Armstrong,Peter D. Walzer,Peter D. Walzer,Peter D. Walzer +25 more
TL;DR: The data suggest that the 40-kDa antigen is a major marker of P. carinii infection and that immunoblotting is useful in measuring serum antibody responses to the organism in both normal and immunocompromised hosts.
References
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TL;DR: Both antibody loss and the risk of severe disease should be considered when booster-dose strategies for the hepatitis B vaccine are being designed.
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A controlled clinical trial of the efficacy of the hepatitis B vaccine (Heptavax B): a final report
Wolf Szmuness,Wolf Szmuness,Cladd E. Stevens,Cladd E. Stevens,Edith A. Zang,Edith A. Zang,Edward J. Harley,Edward J. Harley,Aaron Kellner,Aaron Kellner +9 more
TL;DR: It is confirmed that a highly purified, formalin‐inactivated vaccine against hepatitis B prepared from HBsAg positive plasma, is safe immunogenic, and highly efficacious, and over 95% of vaccinated subjects developed antibody against the surface antigen.
Journal ArticleDOI
The prevention of hepatitis B with vaccine. Report of the centers for disease control multi-center efficacy trial among homosexual men.
Donald P. Francis,Stephen C. Hadler,Sumner E. Thompson,James E. Maynard,David G. Ostrow,Norman L. Altman,Erwin H. Braff,Paul M. O'Malley,Donald Hawkins,Franklyn N. Judson,Kent A. Penley,Thom Nylund,Graham Christie,Frank Meyers,Joseph N. Moore,Ann Gardner,Irene L. Doto,Joe H. Miller,Gladys H. Reynolds,Bert L. Murphy,Charles A. Schable,Brian T. Clark,James Curran,Allan G. Redeker +23 more
TL;DR: This vaccine appears to be safe, immunogenic, and efficacious in preventing infection with hepatitis B virus.
Journal ArticleDOI
Indications for use of hepatitis B vaccine, based on cost-effectiveness analysis.
TL;DR: Screening followed by vaccination of homosexual men and vaccination without prior screening of surgical residents would result in savings of medical costs, and neither screening nor vaccination is the lowest-cost strategy for the general population.