Journal ArticleDOI
Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996
Sundaram Hariharan,Christopher P. Johnson,Barbara A. Bresnahan,S. Taranto,Matthew McIntosh,Donald Stablein +5 more
TLDR
There has been a substantial increase in short-term and long-term survival of kidney grafts from both living and cadaveric donors since 1988.Abstract:
Background The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known. Methods We analyzed the influence of demographic characteristics (age, sex, and race), transplant-related variables (living or cadaveric donor, panel-reactive antibody titer, extent of HLA matching, and cold-ischemia time), and post-transplantation variables (presence or absence of acute rejection, delayed graft function, and therapy with mycophenolate mofetil and tacrolimus) on graft survival for all 93,934 renal transplantations performed in the United States between 1988 and 1996. A regression analysis adjusted for these variables was used to estimate the risk of graft failure within the first year and more than one year after transplantation. Results From 1988 to 1996, the one-year survival rate for grafts from living donors increased from 88.8 to 93.9 percent, and the rate for cadaveric grafts increased...read more
Citations
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Journal ArticleDOI
Incidence of C4d stain in protocol biopsies from renal allografts : Results from a multicenter trial
Michael Mengel,Johannes Bogers,Jean-Louis Bosmans,Daniel Serón,Francesc Moreso,Marta Carrera,Wilfried Gwinner,Anke Schwarz,Marc E. De Broe,Hans Kreipe,Hermann Haller +10 more
TL;DR: Diffuse and focal C4d stain correlated with morphology of humoral rejection in protocol as well as in indication biopsies, showing a significantly lower incidence of C4D deposition than indicationBiopsies.
Journal ArticleDOI
Pre‐Transplant IFN‐γ ELISPOTs Are Associated with Post‐Transplant Renal Function in African American Renal Transplant Recipients
Joshua J. Augustine,David S. Siu,Michael J. Clemente,James A. Schulak,Peter S. Heeger,Donald E. Hricik +5 more
TL;DR: The frequencies of pre‐transplant, donor‐specific interferon‐γ (IFN‐γ) enzyme‐linked immunosorbent spots (ELISPOTs) and correlated the results with post-transplant outcomes in 37 African American recipients of deceased donor kidney transplants treated with tacrolimus‐ and sirolimus-based immunosuppression are determined.
Journal ArticleDOI
A three-arm study comparing immediate tacrolimus therapy with antithymocyte globulin induction therapy followed by tacrolimus or cyclosporine A in adult renal transplant recipients
Bernard Charpentier,Lionel Rostaing,François Berthoux,Philippe Lang,Giovanni Civati,Jean-Louis Touraine,Jean-Paul Squifflet,P. Vialtel,Daniel Abramowicz,Georges Mourad,Philippe Wolf,Elisabeth Cassuto,Bruno Moulin,Gérard Rifle,André Pruna,Pierre Merville,Françoise Mignon,Christophe Legendre,Patrick Le Pogamp,Yvon Lebranchu,Olivier Toupance,Bruno Hurault de Ligny,Guy Touchard,Michel Olmer,Raj Purgus,Claire Pouteil-Noble,Denis Glotz,Bernard Bourbigot,Michel Leski,Jean-pierre Wauters,Michèle Kessler +30 more
TL;DR: Acute rejection was significantly lower in the ATG-Tac group compared with the ATg-CsA and Tac triple groups, and Significantly more hematologic and infectious adverse events were observed in both ATG induction groups.
Journal ArticleDOI
The impact of sirolimus, mycophenolate mofetil, cyclosporine, azathioprine, and steroids on wound healing in 513 kidney-transplant recipients.
Stuart M. Flechner,Lingmei Zhou,Ithaar Derweesh,Barbara Mastroianni,Kathy Savas,David A. Goldfarb,Charles S. Modlin,Venkatesh Krishnamurthi,Andrew C. Novick +8 more
TL;DR: During a 10-year period marked by changing recipient demographics, the introduction of MMF and SRL did not result in a significant increase in transplant wound-healing complications.
Journal ArticleDOI
Donor kidney volume and outcomes following live donor kidney transplantation.
Emilio D. Poggio,S. Hila,B. Stephany,Richard Fatica,Venkatesh Krishnamurthi,C. Del Bosque,David A. Goldfarb,Brian R. Herts,Vincent W. Dennis,Peter S. Heeger,William E. Braun +10 more
TL;DR: It is suggested that transplantation of larger kidneys confers an outcome advantage and larger kidneys should be preferred when selecting from otherwise similar living donors.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. U.S. Renal Transplant Mycophenolate Mofetil Study Group.
TL;DR: This study demonstrated that MMF administered at a dosage of 2 g or 3 g daily, in combination with maintenance CsA and corticosteroids as triple therapy following ATGAM® induction therapy, is more effective than an otherwise identical regimen that includes azathioprine instead of MMF in preventing acute allograft rejection in first cadaveric renal transplant patients.
Journal ArticleDOI
A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group
TL;DR: Tacrolimus is more effective than cyclosporine in preventing acute rejection in cadaveric renal allograft recipients, and significantly reduces the use of antilymphocyte antibody preparations.
Journal ArticleDOI
Risk factors for chronic rejection in renal allograft recipients.
P. S. Almond,A. J. Matas,K. J. Gillingham,David L. Dunn,William D. Payne,Paul F. Gores,Rainer W.G. Gruessner,J. S. Najarian +7 more
TL;DR: In this article, the authors found that acute rejection, CsA dosage < 5 mg/kg/day at 1 year, and infection are the major risk factors for the development of chronic rejection.
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