Journal ArticleDOI
Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996
Sundaram Hariharan,Christopher P. Johnson,Barbara A. Bresnahan,S. Taranto,Matthew McIntosh,Donald Stablein +5 more
TLDR
There has been a substantial increase in short-term and long-term survival of kidney grafts from both living and cadaveric donors since 1988.Abstract:
Background The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known. Methods We analyzed the influence of demographic characteristics (age, sex, and race), transplant-related variables (living or cadaveric donor, panel-reactive antibody titer, extent of HLA matching, and cold-ischemia time), and post-transplantation variables (presence or absence of acute rejection, delayed graft function, and therapy with mycophenolate mofetil and tacrolimus) on graft survival for all 93,934 renal transplantations performed in the United States between 1988 and 1996. A regression analysis adjusted for these variables was used to estimate the risk of graft failure within the first year and more than one year after transplantation. Results From 1988 to 1996, the one-year survival rate for grafts from living donors increased from 88.8 to 93.9 percent, and the rate for cadaveric grafts increased...read more
Citations
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Journal ArticleDOI
Radical retropubic prostatectomy for localized prostate cancer in renal transplant patients.
Ioannis M. Antonopoulos,William C. Nahas,Affonso C. Piovesan,Renato Falci,Hideki Kanashiro,Gilberto A. Alvarez,Miguel Srougi +6 more
TL;DR: Radical retropubic prostatectomy in renal transplant patients is safe, effective, and can be easily performed in the same manner as described by Walsh, regardless of the presence of the allograft.
Journal ArticleDOI
Potential of Noninvasive Serial Assessment of Acute Renal Allograft Rejection by 18F-FDG PET to Monitor Treatment Efficiency
Stefan Reuter,Uta Schnöckel,Bayram Edemir,Rita Schröter,Dominik Kentrup,Hermann Pavenstädt,Otmar Schober,Eberhard Schlatter,Gert Gabriëls,Michael Schäfers +9 more
TL;DR: 18F-FDG PET is proposed as a method to monitor acute rejection of allogeneic renal transplants in a rat model and is an option to noninvasively assess early response to therapy in rat renal allograft rejection.
Journal ArticleDOI
Hypothermic Oxygenated Perfusion: A Simple and Effective Method to Modulate the Immune Response in Kidney Transplantation.
Philipp Kron,Andrea Schlegel,Andrea Schlegel,Xavier Muller,Ariana Gaspert,Pierre-Alain Clavien,Philipp Dutkowski +6 more
TL;DR: This is the first study demonstrating the beneficial effects of HOPE on the immune response following kidney transplantation in an allogeneic rodent model and HOPE-treated kidneys showed better function and less early fibrosis leading to a significantly improved recipient survival.
Journal ArticleDOI
Screening of Living Kidney Donors for Genetic Diseases Using a Comprehensive Genetic Testing Strategy.
Christie P. Thomas,Maria A. Mansilla,Ramakrishna Sompallae,Sara O. Mason,Carla Nishimura,M. J. Kimble,Colleen A. Campbell,Anne E. Kwitek,Benjamin W. Darbro,Zoe A. Stewart,Richard J.H. Smith +10 more
TL;DR: A negative genetic screen combined with negative comparative genomic hybridization in the recipient facilitated counseling of the related donor and this genetic renal disease panel will allow rapid, efficient and cost‐effective evaluation of related LKDs.
Journal ArticleDOI
Sirolimus in pediatric renal transplantation.
TL;DR: The efficacy and safety of Sirolimus (SRL) in 18 patients, who were 10.52 ± 5.03 years at time of transplantation and received a CNI as the core immunosuppression, were evaluated.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. U.S. Renal Transplant Mycophenolate Mofetil Study Group.
TL;DR: This study demonstrated that MMF administered at a dosage of 2 g or 3 g daily, in combination with maintenance CsA and corticosteroids as triple therapy following ATGAM® induction therapy, is more effective than an otherwise identical regimen that includes azathioprine instead of MMF in preventing acute allograft rejection in first cadaveric renal transplant patients.
Journal ArticleDOI
A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group
TL;DR: Tacrolimus is more effective than cyclosporine in preventing acute rejection in cadaveric renal allograft recipients, and significantly reduces the use of antilymphocyte antibody preparations.
Journal ArticleDOI
Risk factors for chronic rejection in renal allograft recipients.
P. S. Almond,A. J. Matas,K. J. Gillingham,David L. Dunn,William D. Payne,Paul F. Gores,Rainer W.G. Gruessner,J. S. Najarian +7 more
TL;DR: In this article, the authors found that acute rejection, CsA dosage < 5 mg/kg/day at 1 year, and infection are the major risk factors for the development of chronic rejection.
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