Journal ArticleDOI
Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996
Sundaram Hariharan,Christopher P. Johnson,Barbara A. Bresnahan,S. Taranto,Matthew McIntosh,Donald Stablein +5 more
TLDR
There has been a substantial increase in short-term and long-term survival of kidney grafts from both living and cadaveric donors since 1988.Abstract:Â
Background The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known. Methods We analyzed the influence of demographic characteristics (age, sex, and race), transplant-related variables (living or cadaveric donor, panel-reactive antibody titer, extent of HLA matching, and cold-ischemia time), and post-transplantation variables (presence or absence of acute rejection, delayed graft function, and therapy with mycophenolate mofetil and tacrolimus) on graft survival for all 93,934 renal transplantations performed in the United States between 1988 and 1996. A regression analysis adjusted for these variables was used to estimate the risk of graft failure within the first year and more than one year after transplantation. Results From 1988 to 1996, the one-year survival rate for grafts from living donors increased from 88.8 to 93.9 percent, and the rate for cadaveric grafts increased...read more
Citations
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Journal ArticleDOI
Immunosuppressive Drugs for Kidney Transplantation
TL;DR: This review considers the use of immunosuppressive drugs in organ transplantation, focusing on renal transplantation.
Journal ArticleDOI
Lack of Improvement in Renal Allograft Survival Despite a Marked Decrease in Acute Rejection Rates Over the Most Recent Era
TL;DR: This work analyzed data provided by the Scientific Registry of Transplant Recipients regarding all adult first renal transplants between 1995 and 2000 to investigate how acute rejection rates have evolved on a national level in the U.S and how this has impacted graft survival in the most recent era of kidney transplantation.
Journal ArticleDOI
Systematic Review: Kidney Transplantation Compared With Dialysis in Clinically Relevant Outcomes
Marcello Tonelli,Natasha Wiebe,Greg Knoll,Aminu K. Bello,S. Browne,D. Jadhav,Scott Klarenbach,John S. Gill +7 more
TL;DR: A systematic review of studies comparing adult chronic dialysis patients with kidney transplantation recipients for clinical outcomes found significantly lower mortality associated with transplantation, and the relative magnitude of the benefit seemed to increase over time.
Journal ArticleDOI
Strategies to improve long-term outcomes after renal transplantation.
TL;DR: Current antirejection therapy, including calcineurin blockers such as cyclosporine and tacrolimus, the interleukin-2 signal-transduction inhibitor sirolimus and the purine-synthesis inhibitor mycophenolate mofetil are discussed, which inhibits the proliferation of T cells and B cells.
Journal ArticleDOI
Post-transplant renal function in the first year predicts long-term kidney transplant survival
Sundaram Hariharan,Maureen A. McBride,Wida S. Cherikh,Christine B. Tolleris,Barbara A. Bresnahan,Christopher P. Johnson +5 more
TL;DR: Recent improvements in graft half-life are related to conservation of renal function within the first year post-transplantation, and one-year creatinine and Delta Creatinine values predict long-term renal graft survival.
References
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Journal Article
Effect of race on renal transplant outcome.
TL;DR: In this paper, the authors compared the outcomes of white and black transplant patients at a single center for a mean period of 37.6 months (1-96) and found that graft survival was lower in black recipients than white recipients.
Contribution of acute rejection to renal allograft loss from chronic rejection
Nabil Sumrani,T. V. Cacciarelli,B. Georgi,P. Daskalakis,Miles Am,K. Goldberg,Joon H. Hong,Bruce G. Sommer +7 more
Journal Article
Outcome of cadaveric renal transplantation by induction treatment in the cyclosporine era
TL;DR: The prevalence of acute rejection was higher with ATGAM, which was also reflected by higher serum creatinine levels, however, the long-term graft function and survival were not different with the various induction treatments.
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