Journal ArticleDOI
Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996
Sundaram Hariharan,Christopher P. Johnson,Barbara A. Bresnahan,S. Taranto,Matthew McIntosh,Donald Stablein +5 more
TLDR
There has been a substantial increase in short-term and long-term survival of kidney grafts from both living and cadaveric donors since 1988.Abstract:
Background The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known. Methods We analyzed the influence of demographic characteristics (age, sex, and race), transplant-related variables (living or cadaveric donor, panel-reactive antibody titer, extent of HLA matching, and cold-ischemia time), and post-transplantation variables (presence or absence of acute rejection, delayed graft function, and therapy with mycophenolate mofetil and tacrolimus) on graft survival for all 93,934 renal transplantations performed in the United States between 1988 and 1996. A regression analysis adjusted for these variables was used to estimate the risk of graft failure within the first year and more than one year after transplantation. Results From 1988 to 1996, the one-year survival rate for grafts from living donors increased from 88.8 to 93.9 percent, and the rate for cadaveric grafts increased...read more
Citations
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Journal ArticleDOI
Dietary Approach to Stop Hypertension (DASH) diet and risk of renal function decline and all‐cause mortality in renal transplant recipients
Maryse C J Osté,António W Gomes-Neto,Eva Corpeleijn,Rijk O. B. Gans,Martin H. de Borst,Else van den Berg,Sabita S. Soedamah-Muthu,Daan Kromhout,Daan Kromhout,Gerjan Navis,Stephan J. L. Bakker +10 more
TL;DR: Adherence to a DASH‐style diet is associated with lower risk of both renal function decline and all‐cause mortality, and results suggest that a healthful diet might benefit long‐term outcome in RTR.
Journal ArticleDOI
Basiliximab versus daclizumab combined with triple immunosuppression in deceased donor renal transplantation: a prospective, randomized study
Aljoša Kandus,Miha Arnol,Katarina Omahen,Manca Oblak,Blanka Vidan-Jeras,Andrej Kmetec,Andrej Bren +6 more
TL;DR: Basiximab or daclizumab combined with triple therapy was an efficient and a safe immunosuppression strategy, demonstrated with low incidence of acute rejections, excellent graft function, high survival rates, and acceptable adverse event profile in adult recipients within the 1st year after deceased donor renal transplantation.
Journal ArticleDOI
Dysregulation of Th17 cells during the early post-transplant period in patients under calcineurin inhibitor based immunosuppression.
Byung Ha Chung,Kyoung Woon Kim,Bo-Mi Kim,Shang Guo Piao,Sun Woo Lim,Bum Soon Choi,Cheol Whee Park,Yong-Soo Kim,Mi-La Cho,Chul Woo Yang +9 more
TL;DR: Current immunosuppression based on tacrolimus is inadequate to suppress Th17 cells in KTRs, and dysregulation of Th17 may be associated with the progression of CAD.
Journal ArticleDOI
Clinical implementation of pharmacogenetics in kidney transplantation: calcineurin inhibitors in the starting blocks.
Laure Elens,Laure Elens,Rachida Bouamar,Nauras Shuker,Dennis A. Hesselink,Teun van Gelder,Ron H.N. van Schaik +6 more
TL;DR: The purpose of the present review is to picture the current status of CNI pharmacogenetics and to discuss the most promising leads that have been followed so far.
Journal ArticleDOI
Cyclosporine induces myocardial connective tissue growth factor in spontaneously hypertensive rats on high-sodium diet.
Piet Finckenberg,Markus Lassila,Kaija Inkinen,Anna-Kaisa Pere,Leena Krogerus,Leena Lindgren,Eero Mervaala,Heikki Vapaatalo,Marja-Leena Nurminen,Juhani Ahonen +9 more
TL;DR: CsA-induced hypertension and nephrotoxicity were associated with myocardial infarcts and vasculopathy of the coronary arteries, and the induction of CTGF gene is mediated, at least in part, by angiotensin II.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. U.S. Renal Transplant Mycophenolate Mofetil Study Group.
TL;DR: This study demonstrated that MMF administered at a dosage of 2 g or 3 g daily, in combination with maintenance CsA and corticosteroids as triple therapy following ATGAM® induction therapy, is more effective than an otherwise identical regimen that includes azathioprine instead of MMF in preventing acute allograft rejection in first cadaveric renal transplant patients.
Journal ArticleDOI
A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group
TL;DR: Tacrolimus is more effective than cyclosporine in preventing acute rejection in cadaveric renal allograft recipients, and significantly reduces the use of antilymphocyte antibody preparations.
Journal ArticleDOI
Risk factors for chronic rejection in renal allograft recipients.
P. S. Almond,A. J. Matas,K. J. Gillingham,David L. Dunn,William D. Payne,Paul F. Gores,Rainer W.G. Gruessner,J. S. Najarian +7 more
TL;DR: In this article, the authors found that acute rejection, CsA dosage < 5 mg/kg/day at 1 year, and infection are the major risk factors for the development of chronic rejection.
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