Journal ArticleDOI
Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996
Sundaram Hariharan,Christopher P. Johnson,Barbara A. Bresnahan,S. Taranto,Matthew McIntosh,Donald Stablein +5 more
TLDR
There has been a substantial increase in short-term and long-term survival of kidney grafts from both living and cadaveric donors since 1988.Abstract:
Background The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known. Methods We analyzed the influence of demographic characteristics (age, sex, and race), transplant-related variables (living or cadaveric donor, panel-reactive antibody titer, extent of HLA matching, and cold-ischemia time), and post-transplantation variables (presence or absence of acute rejection, delayed graft function, and therapy with mycophenolate mofetil and tacrolimus) on graft survival for all 93,934 renal transplantations performed in the United States between 1988 and 1996. A regression analysis adjusted for these variables was used to estimate the risk of graft failure within the first year and more than one year after transplantation. Results From 1988 to 1996, the one-year survival rate for grafts from living donors increased from 88.8 to 93.9 percent, and the rate for cadaveric grafts increased...read more
Citations
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Journal ArticleDOI
The Influence of Various Maintenance Immunosuppressive Drugs on Lymphocele Formation and Treatment After Kidney Transplantation
Mahesh Goel,Stuart M. Flechner,Lingme Zhou,Barbara Mastroianni,Kathy Savas,Ithaar Derweesh,Pratik Patel,Charles S. Modlin,David A. Goldfarb,Andrew C. Novick +9 more
TL;DR: The combination of sirolimus/MMF/P, obesity with a body mass index of greater than 30 kg/m and acute rejection are independent risk factors for lymphocele formation and treatment after kidney transplantation.
Journal ArticleDOI
The superior results of living-donor renal transplantation are not completely caused by selection or short cold ischemia time: a single-center, multivariate analysis.
Joke I. Roodnat,I. C. van Riemsdijk,Paul G.H. Mulder,Ilias I.N. Doxiadis,F.H.J. Claas,J. N. M. Ijzermans,T. van Gelder,W. Weimar +7 more
TL;DR: The superior results of LD versus PMD transplantations can be partly explained by the dichotomy in the cold ischemia period in these populations (selection), however, after adjustment for cold ischemical periods, the influence of donor origin still remained significant, independent of any of the variables introduced.
Journal ArticleDOI
Kidney-targeted naked DNA transfer by retrograde renal vein injection in rats
Hiroki Maruyama,Noboru Higuchi,Yuji Nishikawa,Hiroyuki Hirahara,Noriaki Iino,Shigemi Kameda,Hiroshi Kawachi,Eishin Yaoita,Fumitake Gejyo,Jun-ichi Miyazaki +9 more
TL;DR: This novel technique is simple and safe, allowing high-level and long-term stable gene expression specific to the fibroblasts near the PTC, and should have therapeutic value for future applications in humans.
Journal ArticleDOI
Detection of T suppressor cells in patients with organ allografts
Rodica Ciubotariu,Rodica Vasilescu,Eric K. Ho,Paola Cinti,Corrado Cancedda,Luca Poli,Maurizio Late,Zhuoru Liu,Pasquale Berloco,Raffaello Cortesini,Nicole Suciu-Foca Cortesini +10 more
TL;DR: In this article, the authors developed a flow cytometry method that measures the expression of costimulatory molecules on donor APC exposed to recipient Th and Ts, and demonstrated that quantification of the capacity of CD8 + CD28 − T cells from patient circulation to suppress the activation of CMPs (CD80, CD86) offers a reliable tool for monitoring specific immunosuppression against the graft in solid organ transplantation.
Journal ArticleDOI
Superiority of pediatric en bloc renal allografts over living donor kidneys: a long-term functional study.
TL;DR: Early postoperative graft thrombosis remain a challenge with pediatric en bloc renal transplants, but once the allografts survive early postoperative course, they provide better long-term function than living donor kidney transplants.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. U.S. Renal Transplant Mycophenolate Mofetil Study Group.
TL;DR: This study demonstrated that MMF administered at a dosage of 2 g or 3 g daily, in combination with maintenance CsA and corticosteroids as triple therapy following ATGAM® induction therapy, is more effective than an otherwise identical regimen that includes azathioprine instead of MMF in preventing acute allograft rejection in first cadaveric renal transplant patients.
Journal ArticleDOI
A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group
TL;DR: Tacrolimus is more effective than cyclosporine in preventing acute rejection in cadaveric renal allograft recipients, and significantly reduces the use of antilymphocyte antibody preparations.
Journal ArticleDOI
Risk factors for chronic rejection in renal allograft recipients.
P. S. Almond,A. J. Matas,K. J. Gillingham,David L. Dunn,William D. Payne,Paul F. Gores,Rainer W.G. Gruessner,J. S. Najarian +7 more
TL;DR: In this article, the authors found that acute rejection, CsA dosage < 5 mg/kg/day at 1 year, and infection are the major risk factors for the development of chronic rejection.
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