Journal ArticleDOI
Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996
Sundaram Hariharan,Christopher P. Johnson,Barbara A. Bresnahan,S. Taranto,Matthew McIntosh,Donald Stablein +5 more
TLDR
There has been a substantial increase in short-term and long-term survival of kidney grafts from both living and cadaveric donors since 1988.Abstract:
Background The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known. Methods We analyzed the influence of demographic characteristics (age, sex, and race), transplant-related variables (living or cadaveric donor, panel-reactive antibody titer, extent of HLA matching, and cold-ischemia time), and post-transplantation variables (presence or absence of acute rejection, delayed graft function, and therapy with mycophenolate mofetil and tacrolimus) on graft survival for all 93,934 renal transplantations performed in the United States between 1988 and 1996. A regression analysis adjusted for these variables was used to estimate the risk of graft failure within the first year and more than one year after transplantation. Results From 1988 to 1996, the one-year survival rate for grafts from living donors increased from 88.8 to 93.9 percent, and the rate for cadaveric grafts increased...read more
Citations
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Journal ArticleDOI
Sunscreen Use Before and After Transplantation and Assessment of Risk Factors Associated With Skin Cancer Development in Renal Transplant Recipients
TL;DR: Transplant recipients are poorly compliant with the use of sunscreens both before and after transplantation, and compliance is poorest in those groups at higher risk of nonmelanoma skin cancer.
Journal ArticleDOI
Pediatric renal transplantation with mycophenolate mofetil-based immunosuppression without induction: results after three years1,2
Therese Jungraithmayr,Astrid Staskewitz,Günter Kirste,M. Böswald,Monika Bulla,Rainer Burghard,Jürgen Dippell,Christel Greiner,Udo Helmchen,Bernd Klare,Günter Klaus,Heinz E. Leichter,Michael J. Mihatsch,Dietrich Michalk,Joachim Misselwitz,Christian Plank,Uwe Querfeld,Lutz T. Weber,Manfred Wiesel,Burkhard Tönshoff,Lothar Bernd Zimmerhackl +20 more
TL;DR: Results suggest that MMF is safe and beneficial as a longer term maintenance immunosuppressive drug in children and adolescents after renal transplantation (RTX).
Journal ArticleDOI
Nanoparticle delivery of mycophenolic acid upregulates PD-L1 on dendritic cells to prolong murine allograft survival.
Anushree C. Shirali,Michael Look,Wei Du,E. Kassis,Heather W. Stout-Delgado,Tarek M. Fahmy,Daniel R. Goldstein +6 more
TL;DR: It is found that intermittent treatment with NPs encapsulated with MPA (NP‐MPA) resulted in a significant extension of allograft survival than intermittent conventional MPA treatment even though the concentration of MPA within NP‐M PA was a 1000‐fold lower than conventional drug.
Journal ArticleDOI
A machine learning-based approach to prognostic analysis of thoracic transplantations
TL;DR: This study demonstrated that the integrated machine learning method to select the predictor variables is more effective in developing the Cox survival models than the traditional methods commonly found in the literature.
Journal ArticleDOI
Procuring organ donors as a health investment: how much should we be willing to spend?
TL;DR: The objective was not only to see whether organ procurement is a “good” health investment, but also to clarify how much it is worth spending to obtain additional donors.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. U.S. Renal Transplant Mycophenolate Mofetil Study Group.
TL;DR: This study demonstrated that MMF administered at a dosage of 2 g or 3 g daily, in combination with maintenance CsA and corticosteroids as triple therapy following ATGAM® induction therapy, is more effective than an otherwise identical regimen that includes azathioprine instead of MMF in preventing acute allograft rejection in first cadaveric renal transplant patients.
Journal ArticleDOI
A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group
TL;DR: Tacrolimus is more effective than cyclosporine in preventing acute rejection in cadaveric renal allograft recipients, and significantly reduces the use of antilymphocyte antibody preparations.
Journal ArticleDOI
Risk factors for chronic rejection in renal allograft recipients.
P. S. Almond,A. J. Matas,K. J. Gillingham,David L. Dunn,William D. Payne,Paul F. Gores,Rainer W.G. Gruessner,J. S. Najarian +7 more
TL;DR: In this article, the authors found that acute rejection, CsA dosage < 5 mg/kg/day at 1 year, and infection are the major risk factors for the development of chronic rejection.
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