Journal ArticleDOI
Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996
Sundaram Hariharan,Christopher P. Johnson,Barbara A. Bresnahan,S. Taranto,Matthew McIntosh,Donald Stablein +5 more
TLDR
There has been a substantial increase in short-term and long-term survival of kidney grafts from both living and cadaveric donors since 1988.Abstract:
Background The introduction of cyclosporine has resulted in improvement in the short-term outcome of renal transplantation, but its effect on the long-term survival of kidney transplants is not known. Methods We analyzed the influence of demographic characteristics (age, sex, and race), transplant-related variables (living or cadaveric donor, panel-reactive antibody titer, extent of HLA matching, and cold-ischemia time), and post-transplantation variables (presence or absence of acute rejection, delayed graft function, and therapy with mycophenolate mofetil and tacrolimus) on graft survival for all 93,934 renal transplantations performed in the United States between 1988 and 1996. A regression analysis adjusted for these variables was used to estimate the risk of graft failure within the first year and more than one year after transplantation. Results From 1988 to 1996, the one-year survival rate for grafts from living donors increased from 88.8 to 93.9 percent, and the rate for cadaveric grafts increased...read more
Citations
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Journal ArticleDOI
Y-Box Binding Protein-1 Mediates Profibrotic Effects of Calcineurin Inhibitors in the Kidney
Lydia Hanssen,Björn C. Frye,Tammo Ostendorf,Christina Alidousty,Sonja Djudjaj,Peter Boor,Peter Boor,Thomas Rauen,Jürgen Floege,Peter R. Mertens,Ute Raffetseder +10 more
TL;DR: It is reported that the cold-shock protein Y-box binding protein-1 (YB-1) is a TGF-β independent downstream effector in CsA- as well as in tacrolimus- but not in rapamycin-mediated activation of rat mesangial cells (rMCs) that contributes to renal fibrosis via regulation of its own and collagen translation.
Journal ArticleDOI
Mycophenolic acid pharmacokinetics in stable pediatric renal transplantation
Elias David-Neto,Lilian M. P. Araujo,Nairo Massakazu Sumita,Maria Elizabeth Mendes,Maria Cristina Ribeiro de Castro,Cristiane F. Alves,Erica Kakehashi,Paschoalina Romano,Elisa Midori Yagyu,Margaret Queiroga,William C. Nahas,Luiz Estevam Ianhez +11 more
TL;DR: The use of MMF without monitoring mycophenolic acid (MPA) blood levels may cause unnecessary overexposure to the drug in stable pediatric recipients and should be avoided.
Journal ArticleDOI
Assessment of early renal allograft dysfunction with blood oxygenation level-dependent MRI and diffusion-weighted imaging.
TL;DR: BOLD MRI and DWI at 3 T may demonstrate early functional state of renal allografts, but may be limited in characterizing a cause of early renal allogsraft dysfunction.
Journal ArticleDOI
A Randomized Controlled Trial to Evaluate the Effect of Glycemic Control on Renal Transplantation Outcomes
Kathie L. Hermayer,M.F Egidi,Nancy J. Finch,Prabhakar K. Baliga,Angello Lin,Lindsey Kettinger,Shari Biggins,Rickey E. Carter +7 more
TL;DR: The primary outcome measure of DGF was not statistically different for the two treatment groups, and longer-term rejection and graft survival, the intensively treated participants were at higher risk for a rejection episode.
Journal ArticleDOI
Laparoscopic radical prostatectomy in a renal allograft recipient
TL;DR: This is a case report of laparoscopic prostatectomy for biopsy-proven localized prostate cancer in a renal transplant recipient and an accepted minimally invasive treatment for a middle-aged man with organ-confined prostate cancer.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. U.S. Renal Transplant Mycophenolate Mofetil Study Group.
TL;DR: This study demonstrated that MMF administered at a dosage of 2 g or 3 g daily, in combination with maintenance CsA and corticosteroids as triple therapy following ATGAM® induction therapy, is more effective than an otherwise identical regimen that includes azathioprine instead of MMF in preventing acute allograft rejection in first cadaveric renal transplant patients.
Journal ArticleDOI
A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group
TL;DR: Tacrolimus is more effective than cyclosporine in preventing acute rejection in cadaveric renal allograft recipients, and significantly reduces the use of antilymphocyte antibody preparations.
Journal ArticleDOI
Risk factors for chronic rejection in renal allograft recipients.
P. S. Almond,A. J. Matas,K. J. Gillingham,David L. Dunn,William D. Payne,Paul F. Gores,Rainer W.G. Gruessner,J. S. Najarian +7 more
TL;DR: In this article, the authors found that acute rejection, CsA dosage < 5 mg/kg/day at 1 year, and infection are the major risk factors for the development of chronic rejection.
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