Journal ArticleDOI
Incomplete quality of life data in randomized trials: Missing items
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TLDR
It is shown that imputation using the mean of all observed items in the same subscale may be an inappropriate method for many of the items in quality of life questionnaires, and would result in biased or misleading estimates.Abstract:
Missing data has been a problem in many quality of life studies. This paper focuses upon the issues involved in handling forms which contain one or more missing items, and reviews the alternative procedures. One of the most widely practised approaches is imputation using the mean of all observed items in the same subscale. This, together with the related estimation of the subscale score, is based upon traditional psychometric approaches to scale design and analysis. We show that it may be an inappropriate method for many of the items in quality of life questionnaires, and would result in biased or misleading estimates. We provide examples of items and subscales which violate the psychometric foundations that underpin simple mean imputation. A checklist is proposed for examining the adequacy of simple imputation, and some alternative procedures are indicated.read more
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Quality of Life: Assessment, Analysis, and Interpretation
TL;DR: In this paper, the authors developed and tested a questionnaire for clinical trials and found that the questionnaire scores and measures were validated, reliability, and sensitivity, respectively, in terms of Validity, Reliability, Sensitivity.
Journal ArticleDOI
Dealing with missing data in a multi-question depression scale: a comparison of imputation methods
Fiona M. Shrive,Fiona M. Shrive,Heather Stuart,Heather Stuart,Hude Quan,Hude Quan,William A. Ghali +6 more
TL;DR: Multiple imputation is the most accurate method for dealing with missing data in most of the missind data scenarios the authors assessed for the Zung Self-reported Depression scale.
Journal ArticleDOI
Incidence of treated cardiac arrest in hospitalized patients in the United States.
Raina M. Merchant,Lin Yang,Lance B Becker,Robert A. Berg,Vinay M. Nadkarni,Graham Nichol,Brendan G. Carr,Nandita Mitra,Steven M. Bradley,Benjamin S. Abella,Peter W. Groeneveld +10 more
TL;DR: There are approximately 200,000 treated cardiac arrests among U.S. hospitalized patients annually, and this rate may be increasing, which is important for understanding the burden of inhospital cardiac arrest and developing strategies to improve care for hospitalized patients.
Journal ArticleDOI
Epidemiology of hip and knee pain and its impact on overall health status in older adults
Jill Dawson,Louise Linsell,Krina T. Zondervan,Peter W Rose,T Randall,Andrew Carr,Ray Fitzpatrick +6 more
TL;DR: Patterns of hip and knee symptoms are complex in older people and amongst the symptomatic, most have more than one hip/knee affected, which has implications for treatment and health status measurement.
Journal ArticleDOI
A prospective longitudinal study examining the quality of life of patients with esophageal carcinoma.
TL;DR: Quality of life measurement provides detailed information about outcome from the patient's perspective and the impact on short and long term QL of esophagectomy and palliative treatment in patients with esophageal carcinoma is assessed.
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