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Journal ArticleDOI

Increasing antimicrobial resistance and the management of uncomplicated community-acquired urinary tract infections.

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TLDR
The problem of antimicrobial resistance in acute uncomplicated community-acquired UTI is highlighted, focusing on TMPSMX resistance, and the few available data regarding clinical outcomes associated with in vitro resistance are summarized.
Abstract
The authors highlight the problem of antimicrobial resistance in acute uncomplicated community-acquired urinary tract infection (UTI), summarize the few available data on clinical outcomes associat...

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Journal ArticleDOI

Resistance is futile: the bacteriocin model for addressing the antibiotic resistance challenge

TL;DR: A new paradigm in antibiotic discovery and development is proposed, one that applies ecological and evolutionary theory to design antimicrobial drugs that are more difficult and/or more costly to resist.
Journal ArticleDOI

Effect of Inactivation of the Global Oxidative Stress Regulator oxyR on the Colonization Ability of Escherichia coli O1:K1:H7 in a Mouse Model of Ascending Urinary Tract Infection

TL;DR: The findings indicate that oxyR is a broadly prevalent potential target for future preventive interventions against UTI due to E. coli UTI and that the major oxidative stresses against which OxyR protects E. Escherichia coli within the host milieu are not phagocyte derived.
Journal ArticleDOI

Occurrence of Antibiotic-Resistant Uropathogenic Escherichia coli Clonal Group A in Wastewater Effluents

TL;DR: The occurrence of “human-type” E. coli CGA in wastewater effluents demonstrates a potential mode for the dissemination of this clonal group in the environment, with possible secondary transmission to new human or animal hosts.
References
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Book

Principles and Practice of Infectious Diseases

TL;DR: This updated and expanded edition now offers 297 chapters that cover the basic principles of diagnosis and management, major clinical syndromes, all important pathogenic microbes and the diseases they cause, plus a number of specialised topics useful to the practitioner.
Journal ArticleDOI

Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women

TL;DR: This guideline is to provide assistance to clinicians in the diagnosis and treatment of two specific types of urinary tract infections (UTIs): uncomplicated, acute, symptomatic bacterial cystitis and acute pyelonephritis in women.
Journal ArticleDOI

Management of urinary tract infections in adults.

TL;DR: This review will highlight recent advances in the treatment of patients in each of these categories, emphasizing cost-effective strategies that may be particularly important in the coming era.
Journal ArticleDOI

Diagnosis and treatment of uncomplicated urinary tract infection

TL;DR: The optimal treatment duration for acute uncomplicated pyelonephritis has not been established, but 10- to 14-day regimens are recommended, and patients prefer to use antimicrobials that attain high renal tissue levels, such as a fluoroquinolone, trimethoprim-sulfamethoxazole, or an aminoglycoside for pyel onephritis.
Journal ArticleDOI

Increasing prevalence of antimicrobial resistance among uropathogens causing acute uncomplicated cystitis in women.

TL;DR: While the prevalence of resistance to trimethoprim-sulfamethoxazole, ampicillin, and cephalothin increased significantly among uropathogens causing acute cystitis, resistance to nitrofurantoin and ciprofloxacin remained infrequent.
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