Journal ArticleDOI
Increasing antimicrobial resistance and the management of uncomplicated community-acquired urinary tract infections.
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TLDR
The problem of antimicrobial resistance in acute uncomplicated community-acquired UTI is highlighted, focusing on TMPSMX resistance, and the few available data regarding clinical outcomes associated with in vitro resistance are summarized.Abstract:
The authors highlight the problem of antimicrobial resistance in acute uncomplicated community-acquired urinary tract infection (UTI), summarize the few available data on clinical outcomes associat...read more
Citations
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Journal ArticleDOI
Consequences of switching from a fixed 2 : 1 ratio of amoxicillin/clavulanate (CLSI) to a fixed concentration of clavulanate (EUCAST) for susceptibility testing of Escherichia coli
Maurine A. Leverstein-van Hall,Karola Waar,Jan Muilwijk,James Cohen Stuart,L. J. M. Sabbe,H. M. E. Frenay,B. Maraha,P. H. J. van Keulen,J. A. J. W. Kluytmans,B. M. de Jongh,Bart J. M. Vlaminckx,E. I. G. B. de Brauwer,Frans S. Stals,L. J. Bakker,J.W. Dorigo-Zetsma,F. W. Sebens,E. E. Mattsson,J. A. Kaan,Steven F. T. Thijsen,A.G.M. Buiting,R. G. F. Wintermans,B.C. van Hees,R. W. Brimicombe,Gijs J.H.M. Ruijs,M. J. H. M. Wolfhagen,J. H. van Zeijl,K. Waar,Nicole H. M. Renders,Alexandra T. Bernards,F. G. C. Heilmann,T. Halaby,B. P. Overbeek,J. F. P. Schellekens,C. L. Jansen,F. Vlaspolder,J. Alblas,A. K. van der Bij,Tjalling Leenstra,M. A. Leversteijn-van Hall,J. Monen,J. Muilwijk,H. T. Tjhie,Patrick D. J. Sturm,B. M. W. Diederen,A. A. Van Zwet,M. P. D. Deege,C. H. E. Boel,J.W. Cohen Stuart,B. G. A. Hendrickx +48 more
TL;DR: E EUCAST methodology resulted in higher co-amoxiclav E. coli resistance rates than CLSI methodology, but correlated better with clinical outcome, and EUCAST-compliant microdilution and disc diffusion provided discrepant results.
Journal ArticleDOI
Fimch antiserum inhibits the adherence of escherichia coli to cells collected by voided urine specimens of diabetic women
Ruby Meiland,SE Geerlings,Solomon Langermann,Ellen C. Brouwer,Frank E. J. Coenjaerts,Andy I. M. Hoepelman +5 more
TL;DR: Findings suggest that a vaccine based on FimH adhesin of type 1 fimbriated E. coli is a potential method of preventing urinary tract infection in women with DM.
Journal ArticleDOI
Network Analysis Reveals Sex- and Antibiotic Resistance-Associated Antivirulence Targets in Clinical Uropathogens
TL;DR: Targeting resistance- or sex-associated VFs based upon contemporary network analysis and biclustering algorithms may facilitate individualized anti-infective therapies and identify synergistic VF combinations in bacterial pathogens.
Journal ArticleDOI
The effectiveness of nitrofurantoin, fosfomycin and trimethoprim for the treatment of cystitis in relation to renal function.
T. ten Doesschate,E. van Haren,Rixt A. Wijma,Birgit C. P. Koch,M. J. M. Bonten,C.H. van Werkhoven +5 more
TL;DR: Renal function should be considered in the clinical decision-making for cystitis treatment, if known, in eGFR ≥60 mL/min treatment with fosfomycin or trimethoprim for uncomplicated Cystitis was associated with more clinical failure than nitrofurantoin, while in eEGFR <60mL/min nitro furantoin wasassociated with moreclinical failure than fosFomycin-trometamol.
Journal ArticleDOI
Rethinking the composition of a rational antibiotic arsenal for the 21st century
TL;DR: It is necessary to usher in a new conception of the role of antibiotics in treatment: away from single molecules that target broad phylogenetic spectra and towards targeted molecules that cripple the pathogen while leaving the rest of the microbiome largely intact.
References
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Book
Principles and Practice of Infectious Diseases
TL;DR: This updated and expanded edition now offers 297 chapters that cover the basic principles of diagnosis and management, major clinical syndromes, all important pathogenic microbes and the diseases they cause, plus a number of specialised topics useful to the practitioner.
Journal ArticleDOI
Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women
John W. Warren,Elias Abrutyn,J. Richard Hebel,James R. Johnson,Anthony J. Schaeffer,Walter E. Stamm +5 more
TL;DR: This guideline is to provide assistance to clinicians in the diagnosis and treatment of two specific types of urinary tract infections (UTIs): uncomplicated, acute, symptomatic bacterial cystitis and acute pyelonephritis in women.
Journal ArticleDOI
Management of urinary tract infections in adults.
Walter E. Stamm,Thomas M. Hooton +1 more
TL;DR: This review will highlight recent advances in the treatment of patients in each of these categories, emphasizing cost-effective strategies that may be particularly important in the coming era.
Journal ArticleDOI
Diagnosis and treatment of uncomplicated urinary tract infection
Thomas M. Hooton,Walter E. Stamm +1 more
TL;DR: The optimal treatment duration for acute uncomplicated pyelonephritis has not been established, but 10- to 14-day regimens are recommended, and patients prefer to use antimicrobials that attain high renal tissue levels, such as a fluoroquinolone, trimethoprim-sulfamethoxazole, or an aminoglycoside for pyel onephritis.
Journal ArticleDOI
Increasing prevalence of antimicrobial resistance among uropathogens causing acute uncomplicated cystitis in women.
TL;DR: While the prevalence of resistance to trimethoprim-sulfamethoxazole, ampicillin, and cephalothin increased significantly among uropathogens causing acute cystitis, resistance to nitrofurantoin and ciprofloxacin remained infrequent.
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Diagnosis and treatment of uncomplicated urinary tract infection
Thomas M. Hooton,Walter E. Stamm +1 more