Individual exposures to drinking water trihalomethanes, low birth weight and small for gestational age risk: a prospective Kaunas cohort study.
Regina Grazuleviciene,Mark J. Nieuwenhuijsen,Jone Vencloviene,Maria Kostopoulou-karadanelli,Stuart W. Krasner,Asta Danileviciute,Gediminas Balcius,Violeta Kapustinskiene +7 more
TLDR
THM internal dose in pregnancy varies substantially across individuals, and depends on both water THM levels and water use habits, and increased internal dose may affect fetal growth.Abstract:
Evidence for an association between exposure during pregnancy to trihalomethanes (THMs) in drinking water and impaired fetal growth is still inconsistent and inconclusive, in particular, for various exposure routes. We examined the relationship of individual exposures to THMs in drinking water on low birth weight (LBW), small for gestational age (SGA), and birth weight (BW) in singleton births. We conducted a cohort study of 4,161 pregnant women in Kaunas (Lithuania), using individual information on drinking water, ingestion, showering and bathing, and uptake factors of THMs in blood, to estimate an internal dose of THM. We used regression analysis to evaluate the relationship between internal THM dose and birth outcomes, adjusting for family status, education, smoking, alcohol consumption, body mass index, blood pressure, ethnic group, previous preterm, infant gender, and birth year. The estimated internal dose of THMs ranged from 0.0025 to 2.40 mg/d. We found dose-response relationships for the entire pregnancy and trimester-specific THM and chloroform internal dose and risk for LBW and a reduction in BW. The adjusted odds ratio for third tertile vs. first tertile chloroform internal dose of entire pregnancy was 2.17, 95% CI 1.19-3.98 for LBW; the OR per every 0.1 μg/d increase in chloroform internal dose was 1.10, 95% CI 1.01-1.19. Chloroform internal dose was associated with a slightly increased risk of SGA (OR 1.19, 95% CI 0.87-1.63 and OR 1.22, 95% CI 0.89-1.68, respectively, for second and third tertile of third trimester); the risk increased by 4% per every 0.1 μg/d increase in chloroform internal dose (OR 1.04, 95% CI 1.00-1.09). THM internal dose in pregnancy varies substantially across individuals, and depends on both water THM levels and water use habits. Increased internal dose may affect fetal growth.read more
Citations
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Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water.
Clara H. Jeong,Cristina Postigo,Susan D. Richardson,Jane Ellen Simmons,Susana Y. Kimura,Benito J. Mariñas,Damià Barceló,Damià Barceló,Pei Liang,Elizabeth D. Wagner,Michael J. Plewa +10 more
TL;DR: This study provided the first systematic, quantitative comparison of HAL toxicity in Chinese hamster ovary cells, and found the HALs were highly cytotoxic compared to other DBP chemical classes.
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Occurrence and Toxicity of Disinfection Byproducts in European Drinking Waters in Relation with the HIWATE Epidemiology Study
Clara H. Jeong,Elizabeth D. Wagner,Vincent R. Siebert,Sridevi Anduri,Susan D. Richardson,Eric J. Daiber,A. Bruce McKague,Manolis Kogevinas,Cristina M. Villanueva,Emma H. Goslan,Wentai Luo,Lorne M. Isabelle,James F. Pankow,Regina Grazuleviciene,Sylvaine Cordier,Susan C. Edwards,Elena Righi,Mark J. Nieuwenhuijsen,Michael J. Plewa +18 more
TL;DR: The HIWATE project was a systematic analysis that combined the epidemiology on adverse pregnancy outcomes and other health effects with long-term exposure to low levels of drinking water disinfection byproducts in the European Union, and this study is the first to integrate quantitative in vitro toxicological data with analytical chemistry and human epidemiologic outcomes for drinking water DBPs.
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Changes in dissolved organic matter during the treatment processes of a drinking water plant in Sweden and formation of previously unknown disinfection byproducts.
Michael Gonsior,Philippe Schmitt-Kopplin,Helena Stavklint,Susan D. Richardson,Norbert Hertkorn,David Bastviken +5 more
TL;DR: This study underlines the fact that a large and increasing number of people are exposed to a very diverse pool of organohalogens through water, by both drinking and uptake through the skin upon contact.
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Surrounding greenness, proximity to city parks and pregnancy outcomes in Kaunas cohort study.
Regina Grazuleviciene,Asta Danileviciute,Audrius Dedele,Jone Vencloviene,Sandra Andrusaityte,Inga Uždanaviciute,Mark J. Nieuwenhuijsen +6 more
TL;DR: An increase in distance to a city parks was associated with an increase in risk of preterm birth and decrease of gestational age, and both higher surrounding greenness level and proximity to park have beneficial effects on pregnancy outcomes.
Journal ArticleDOI
Determinants of the urinary and serum metabolome in children from six European populations.
Chung-Ho E Lau,Alexandros P. Siskos,Léa Maitre,Oliver Robinson,Toby J. Athersuch,Elizabeth J. Want,Jose Urquiza,Maribel Casas,Marina Vafeiadi,Theano Roumeliotaki,Rosemary R. C. McEachan,Rafaq Azad,Line Småstuen Haug,Helle Margrete Meltzer,Sandra Andrusaityte,Inga Petraviciene,Regina Grazuleviciene,Cathrine Thomsen,John Wright,Rémy Slama,Leda Chatzi,Martine Vrijheid,Hector C. Keun,Muireann Coen,Muireann Coen +24 more
TL;DR: A pan-European reference metabolome for urine and serum of healthy children is established and critical resources not previously available are gathered for future investigations into the influence of the metabolome on child health.
References
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Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review
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TL;DR: The studies of THMs and adverse birth outcomes provide moderate evidence for associations with SGA, neural tube defects (NTDs), and spontaneous abortions and the findings of excess NTDs, oral clefts, cardiac defects, and choanal atresia in studies that evaluated TCE-contaminated drinking water deserve follow-up.
Journal ArticleDOI
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Exposure to trihalomethanes and adverse pregnancy outcomes.
TL;DR: A retrospective cohort study in Colorado matched Colorado birth certificates from January 1, 1990, through December 31, 1993 to historical water sample data with respect to time and location of maternal residence to identify a potentially important relation between third trimester exposure to trihalomethanes and retarded fetal growth.