Journal ArticleDOI
Individualized Metabolic Surgery Score: Procedure Selection Based on Diabetes Severity.
Ali Aminian,Stacy A. Brethauer,Amin Andalib,Amy S. Nowacki,Amanda Jiménez,Ricard Corcelles,Zubaidah Nor Hanipah,Suriya Punchai,Deepak L. Bhatt,Sangeeta R. Kashyap,Bartolome Burguera,Antonio M. Lacy,Josep Vidal,Philip R. Schauer +13 more
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TLDR
This is the largest reported cohort with long-term postoperative glycemic follow-up, which categorizes T2DM into 3 validated severity stages for evidence-based procedure selection, and categorizes RYGB was significantly more effective than SG, likely related to its more pronounced neurohormonal effects.Abstract:
Objective:To construct and validate a scoring system for evidence-based selection of bariatric and metabolic surgery procedures according to severity of type 2 diabetes (T2DM).Background:Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) account for >95% of bariatric procedures in United Stread more
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Journal ArticleDOI
Discordance in prediction for prognosis of type 2 diabetes after metabolic surgery: comparison of the ABCD, DiaRem, and individualized metabolic surgery models.
TL;DR: ABCD and DiaRem scores showed significant discordance when applied to potential metabolic surgery candidates in whom postoperative T2D remission rate was highly expected, and these scores showed a dose-response association with DiaRem score but had no significant association with the ABCD score.
Journal ArticleDOI
[Bariatric surgery: Expectations and therapeutic goals-a contradiction?]
TL;DR: Patients with relevant obesity-related metabolic comorbidities should be prioritized for treatment and if possible before the occurrence of end-organ damage that is at least in some cases irreversible and which also increases the perioperative risk.
Journal ArticleDOI
Laparoscopic loop duodenaljejunal bypass with sleeve gastrectomy in type 2 diabetic patients.
TL;DR: At 2 years of follow-up, LDJB-SG is a relatively safe and effective metabolic surgery with significant weight loss and resolution of co-morbidities and no patient needed revisional surgery because of dumping syndrome, marginal ulcer, or gastroesophageal reflux disease.
Journal ArticleDOI
Remission of Diabetes Following Bariatric Surgery: Plasma Proteomic Profiles.
TL;DR: In this paper, the authors evaluated the plasma protein profiles associated with the T2D remission after obesity surgery and found that the resolution of diabetes after bariatric surgery is associated with specific changes in the plasma proteomic profiles of proteins involved in acute-phase response, fibrinolysis, platelet degranulation, and blood coagulation.
Journal ArticleDOI
Laparoscopic Roux-en-Y gastric bypass for excess weight and diabetes: a multicenter retrospective cohort study in China
Wah Yang,Shaihong Zhu,Zhong Cheng,Nengwei Zhang,Liangping Wu,Yi Chen,Jingge Yang,Shuqing Yu,Tengfei Yang,Ding Ding,Jason R. Waggoner,Michael Schwiers,Elliott J. Fegelman,Cunchuan Wang +13 more
TL;DR: RYGB may be effective for weight loss and type 2 diabetes mellitus control in Chinese patients, and outcomes are consistent with the literature in Western populations.
References
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Journal ArticleDOI
Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 5-Year Outcomes
Philip R. Schauer,Deepak L. Bhatt,John P. Kirwan,Kathy Wolski,Ali Aminian,Stacy A. Brethauer,Sankar D. Navaneethan,Rishi P. Singh,Claire E. Pothier,Steven E. Nissen,Sangeeta R. Kashyap +10 more
TL;DR: Five‐year outcome data showed that, among patients with type 2 diabetes and a BMI of 27 to 43, bariatric surgery plus intensive medical therapy was more effective thanintensive medical therapy alone in decreasing, or in some cases resolving, hyperglycemia.
Journal ArticleDOI
Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes
Philip R. Schauer,Deepak L. Bhatt,John P. Kirwan,Kathy Wolski,Stacy A. Brethauer,Sankar D. Navaneethan,Ali Aminian,Claire E. Pothier,Steven E. Nissen,Sangeeta R. Kashyap,Abstr Act +10 more
TL;DR: Among obese patients with uncontrolled type 2 diabetes, 3 years of intensive medical therapy plus bariatric surgery resulted in glycemic control in significantly more patients than did medical therapy alone.
Journal ArticleDOI
Bariatric-metabolic surgery versus conventional medical treatment in obese patients with type 2 diabetes: 5 year follow-up of an open-label, single-centre, randomised controlled trial
Geltrude Mingrone,Geltrude Mingrone,Simona Panunzi,Andrea De Gaetano,Caterina Guidone,Amerigo Iaconelli,Giuseppe Nanni,Marco Castagneto,Stefan R. Bornstein,Francesco Rubino +9 more
TL;DR: Surgery is more effective than medical treatment for the long-term control of obese patients with type 2 diabetes and should be considered in the treatment algorithm of this disease, however, continued monitoring of glycaemic control is warranted because of potential relapse of hyperglycaemia.
Journal ArticleDOI
How Do We Define Cure of Diabetes
John B. Buse,Sonia Caprio,William T. Cefalu,Antonio Ceriello,Stefano Del Prato,Silvio E. Inzucchi,Sue McLaughlin,Gordon L. Phillips,R. Paul Robertson,Francesco Rubino,Richard Kahn,M. Sue Kirkman +11 more
TL;DR: A consensus group of experts comprised of experts in pediatric and adult endocrinology, diabetes education, transplantation, metabolism, bariatric/metabolic surgery, and (for another perspective) hematology-oncology met in June 2009 to discuss issues.
Journal ArticleDOI
Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations
Francesco Rubino,David M. Nathan,Robert H. Eckel,Philip R. Schauer,K. George M.M. Alberti,Paul Zimmet,Stefano Del Prato,Linong Ji,Shaukat Sadikot,William H. Herman,Stephanie A. Amiel,Lee M. Kaplan,Gaspar Taroncher-Oldenburg,David E. Cummings +13 more
TL;DR: Although additional studies are needed to further demonstrate long-term benefits, there is sufficient clinical and mechanistic evidence to support inclusion of metabolic surgery among antidiabetes interventions for people with T2D and obesity.