Journal ArticleDOI
Influence of age on surgical treatment and postoperative outcomes of patients with colorectal cancer in Denmark and Yorkshire, England
John C. Taylor,Lene Hjerrild Iversen,D. Burke,P. J. Finan,Simon J. Howell,Lars Pedersen,Mark M. Iles,Eva Morris,Philip Quirke +8 more
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In this paper, the authors identify differences in the management of colorectal cancer surgery and post-operative outcomes according to patient age between Denmark and Yorkshire and find that the use of major surgical resection was higher in Denmark than in Yorkshire, especially for patients aged ≥ 80 years.Abstract:
Aim Denmark and Yorkshire are demographically similar and both have undergone changes in their management of colorectal cancer to improve outcomes. The differential provision of surgical treatment, especially in the older age groups, may contribute to the magnitude of improved survival rates. This study aimed to identify differences in the management of colorectal cancer surgery and postoperative outcomes according to patient age between Denmark and Yorkshire. Method This was a retrospective population-based study of colorectal cancer patients diagnosed in Denmark and Yorkshire between 2005 and 2016. Proportions of patients undergoing major surgical resection, postoperative mortality and relative survival were compared between Denmark and Yorkshire across several age groups (18-59, 60-69, 70-79 and ≥80 years) and over time. Results The use of major surgical resection was higher in Denmark than in Yorkshire, especially for patients aged ≥80 years (70.5% versus 50.5% for colon cancer, 49.3% versus 38.1% for rectal cancer). Thirty-day postoperative mortality for Danish patients aged ≥80 years was significantly higher than that for Yorkshire patients with colonic cancer [OR (95% CI) = 1.22 (1.07, 1.38)] but not for rectal cancer or for 1-year postoperative mortality. Relative survival significantly increased in all patients aged ≥80 years except for Yorkshire patients with colonic cancer. Conclusion This study suggests that there are major differences between the management of elderly patients with colorectal cancer between the two populations. Improved selection for surgery and better peri- and postoperative care in these patients appears to improve long-term outcomes, but may come at the cost of a higher 30-day mortality.read more
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Comparison of surgical and oncologic outcomes in very elderly patients (≥ 80 years old) and elderly (65–79 years old) colorectal cancer patients: a propensity score matching
TL;DR: In this article , the authors investigated the short-term outcomes and prognosis of elderly and very elderly colorectal cancer patients after primary CRC surgery using propensity score matching (PSM).
Journal ArticleDOI
Differences in the management of patients requiring an emergency resection for colonic cancer in two European populations
John Taylor,Lene Hjerrild Iversen,Dermot Burke,Paul J. Finan,Mark M. Iles,Eva Morris,Philip Quirke +6 more
TL;DR: Patients in Denmark experienced a reduction in the use of emergency resection and increase in stenting procedures, following the policy implemented in some departments of converting potential emergency resections into elective resections.
Journal ArticleDOI
Editorial: Surgical oncology in the elderly: the state of the art and future challenges
TL;DR: Sperti et al. as discussed by the authors presented an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), provided the original author(s) and the copyright owner(s).
Journal ArticleDOI
Outcomes of emergency surgical interventions in right-sided colonic cancer: nationwide population-based study based on Danish Colorectal Cancer Group register
TL;DR: In this paper , the authors investigated the trends in morbidity and mortality of patients with right-sided colonic cancer who had an emergency surgical procedure in Denmark after the introduction of quality index parameters.
Journal ArticleDOI
Clinical efficacy of chemotherapy in colorectal cancer patients over 80 years old
TL;DR: In this article , the effect of chemotherapy on the prognosis of patients with colorectal cancer over 80 years old was defined and compared by Kaplan-Meier method and compared with log-rank test.
References
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Mayer-da-Silva,Ana Miranda,L M Blaga,Daniela Coza,L Gusenkova,O Lazarevich,O Prudnikova,D M Vjushkov,A G Egorova,A E Orlov,L A Kudyakov,L V Pikalova,J Adamcik,C. Safaei Diba,Maja Primic-Žakelj,Vesna Zadnik,Nerea Larrañaga,A. López De Munain,A A Herrera,R Redondas,Rafael Marcos-Gragera,M.L. Vilardell Gil,E Molina,M J Sánchez Perez,P Franch Sureda,M Ramos Montserrat,M-D Chirlaque,Carmen Navarro,Eva Ardanaz,M M Guevara,R Fernández-Delgado,Rafael Peris-Bonet,Marià Carulla,Jaume Galceran,C Alberich,M Vicente-Raneda,Sofia Khan,David Pettersson,Paul W. Dickman,I Avelina,K Staehelin,B Camey,C. Bouchardy,R Schaffar,H. Frick,C. Herrmann,Jean-Luc Bulliard,M Maspoli-Conconi,Claudia E. Kuehni,S M Redmond,Andrea Bordoni,L Ortelli,Arnaud Chiolero,Isabelle Konzelmann,K.L. Matthes,Sabine Rohrmann,J Broggio,Jem Rashbass,Deirdre Fitzpatrick,Anna Gavin,D I Clark,Andrew Deas,Dyfed Wyn Huws,Ceri White,L Montel,Bernard Rachet,Adrian Turculet,Richard Stephens,E Chalker,H Phung,Richard Walton,H You,Steven Guthridge,F Johnson,P Gordon,K D'Onise,K Priest,B.C. Stokes,A Venn,Helen Farrugia,Vicky Thursfield,J Dowling,David C. Currow,J Hendrix,C Lewis +594 more
TL;DR: For most cancers, 5-year net survival remains among the highest in the world in the USA and Canada, in Australia and New Zealand, and in Finland, Iceland, Norway, and Sweden, while for many cancers, Denmark is closing the survival gap with the other Nordic countries.
Journal ArticleDOI
The Danish Cancer Registry
TL;DR: In 2008 the Cancer Registry finished a process of modernisation where reporting became electronic through integration with the patient administrative systems and manual coding was partly replaced by an automatic coding logic.
Journal ArticleDOI
Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995–2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data
Michel P Coleman,David Forman,Heather Bryant,John Butler,Bernard Rachet,Camille Maringe,Ula Nur,Elizabeth Tracey,Michael Coory,Juanita Hatcher,Colleen E. McGahan,D Turner,Loraine D. Marrett,ML Gjerstorff,Tom Børge Johannesen,Jan Adolfsson,Mats Lambe,Mats Lambe,Glenda Lawrence,David Meechan,Eva Morris,Richard Middleton,John Steward,Michael Richards +23 more
TL;DR: In this paper, the first study in a programme to investigate international survival disparities, with the aim of informing health policy to raise standards and reduce inequalities in survival, was presented, where data from population-based cancer registries in 12 jurisdictions in six countries were provided for 2·4 million adults diagnosed with primary colorectal, lung, breast, ovarian, or ovarian cancer during 1995-2007, with follow-up to Dec 31, 2007.
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Health Care Spending in the United States and Other High-Income Countries
TL;DR: The United States spent approximately twice as much as other high-income countries on medical care, yet utilization rates in the United States were largely similar to those in other nations, and prices of labor and goods, including pharmaceuticals, and administrative costs appeared to be the major drivers of the difference in overall cost.
Journal ArticleDOI
Progress in cancer survival, mortality, and incidence in seven high-income countries 1995–2014 (ICBP SURVMARK-2): a population-based study
Melina Arnold,Mark J. Rutherford,Mark J. Rutherford,Aude Bardot,Jacques Ferlay,Therese M.-L. Andersson,Tor Åge Myklebust,Hanna E. Tervonen,Vicky Thursfield,David Ransom,Lorraine Shack,Ryan Woods,Donna Turner,Suzanne Leonfellner,S Ryan,Nathalie Saint-Jacques,Prithwish De,Carol McClure,Agnihotram V. Ramanakumar,H Stuart-Panko,Gerda Engholm,Paul M. Walsh,Christopher Jackson,Sally Vernon,Eileen Morgan,Anna Gavin,David S. Morrison,Dyfed Wyn Huws,Geoff Porter,John Butler,Heather Bryant,David C. Currow,Sara Hiom,D. Max Parkin,Peter Sasieni,Paul C. Lambert,Paul C. Lambert,Bjørn Møller,Isabelle Soerjomataram,Freddie Bray +39 more
TL;DR: Progress in cancer control over the study period was evident for stomach, colon, lung (in males), and ovarian cancer, and the impact of comorbidity are likely the main determinants of patient outcomes.