Journal ArticleDOI
Influence of caffeine on arecoline-induced SCE in mouse bone-marrow cells in vivo
G.B. Panigrahi,A.R. Rao +1 more
TLDR
There was a significant increase in the frequency of SCEs after exposure to either arecoline or caffeine, and when these two alkaloids were given in combination, the SCE frequency-enhancing effect was additive.About:
This article is published in Mutation Research Letters.The article was published on 1983-12-01. It has received 33 citations till now. The article focuses on the topics: Arecoline & Betel.read more
Citations
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ReviewSister-chromatid exchange: second report of the Gene-Tox program
James D. Tucker,Angela E. Auletta,Michael C. Cimino,Kerry L. Dearfield,David Jacobson-Kram,Raymond R. Tice,Anthony V. Carrano +6 more
TL;DR: In this article, the ability of a number of chemicals to induce sister-chromatid exchanges (SCEs) was reviewed, and the SCE data for animal cells in vivo and in vitro, and human cells in vitro were presented in 6 tables according to their relative effectiveness.
Journal ArticleDOI
Immunosuppression, hepatotoxicity and depression of antioxidant status by arecoline in albino mice
Romi Dasgupta,Indraneel Saha,Suman Pal,Arindam Bhattacharyya,Gaurisankar Sa,Tapas Chandra Nag,Tania Das,B.R. Maiti +7 more
TL;DR: It is concluded that arecoline attacks multiple targets to finally generate systemic toxicity in mice and caused depression of antioxidants, i.e., superoxide dismutase (SOD), catalase, reduced glutathione (GSH) and glutATHione-S-transferase (GST) that are known to neutralize reactive oxygen species.
Journal ArticleDOI
Modifying influences of betel quid ingredients on B(a)P-induced carcinogenesis in the buccal pouch of hamster
TL;DR: There was a considerable increase in tumor incidence in hamster buccal pouches following short‐term and long‐term topical exposures to graded doses of benzo(a)pyrene, B( a)P alone or in combination with extract of tobacco, betel nut or betel leaf extract.
Journal ArticleDOI
Habitual Betel Quid Chewing and Risk for Hepatocellular Carcinoma Complicating Cirrhosis
Jung-Fa Tsai,Jen-Eing Jeng,Lee-Yea Chuang,Mei-Shang Ho,Ying-Chin Ko,Zu-Yau Lin,Min-Yuh Hsieh,Shin-Chern Chen,Wan-Lung Chuang,Liang-Yen Wang,Ming-Lung Yu,Chia-Yen Dai +11 more
TL;DR: It is concluded that betel quid chewing is an independent risk factor for cirrhotic HCC and there is an additive interaction between betelquid chewing and chronic hepatitis B and/or hepatitis C virus infection.
Journal ArticleDOI
Role of areca nut consumption in the cause of oral cancers. A cytogenetic assessment
TL;DR: Cytogenetic studies were performed to assess the possible genomic damage caused by areca nut consumption (without tobacco and not as a component of betel quid), which included normal people who chew areca nuts, patients with oral submucous fibrosis, and patients with cancer, and healthy nonchewing controls.
References
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Coffee and Cancer of the Pancreas
TL;DR: Patients with histologically proved cancer of the pancreas and control patients were questioned about their use of tobacco, alcohol, tea, and coffee and there was a weak positive association with cancer.
Journal ArticleDOI
Genetics of somatic mammalian cells. IX. Quantitation of mutagenesis by physical and chemical agents
Fa-Ten Kao,Theodore T. Puck +1 more
TL;DR: The system previously described for inducing single gene mutations in Chinese hamster cells has been extended to produce additional auxotrophic mutants and an improved method for quantitating the efficiency of single gene mutation to specific auxotrophies has been developed.
Journal ArticleDOI
Evaluation of cancer risk in tobacco chewers and smokers: an epidemiologic assessment
D. J. Jussawalla,V. A. Deshpande +1 more
TL;DR: It is revealing to find that the high risk sites involved in tobacco chewers appear to be the least affected in smokers, and vice versa.
Related Papers (5)
Potentiation of genotoxicity by concurrent application of compounds found in betel quid: arecoline, eugenol, quercetin, chlorogenic acid and Mn2+.
H.F. Stich,W. Stich,P. Lam +2 more