Journal ArticleDOI
Influence of physical training on blood pressure, plasma renin, angiotensin and catecholamines in patients with ischaemic heart disease.
Reads0
Chats0
TLDR
A reduced sympathetic tone after training, suggested by the lower heart rates and the tendency to a decrease in PNE, is a likely explanation for the decreases in PRA and aldosterone concentration after training.Abstract:
Eighteen patients with ischaemic heart disease were trained for 3 months, three times a week. The effectiveness of the training programme was demonstrated by increases of 27% in peak oxygen uptake and 29% in exercise duration, and by a decrease in resting and submaximal heart rates. Blood pressure, however, was not significantly affected during the training period. At rest and at submaximal exercise plasma renin activity (PRA) was lower after training. Plasma angiotensin I concentration (PA I) and angiotensin II concentration (PA II) were not significantly affected. Plasma aldosterone concentration (PAC), only measured at rest, was not significantly changed after the training period, while plasma norepinephrine (PNE) and epinephrine (PE) concentrations were significantly decreased, but only at high levels of exercise. A reduced sympathetic tone after training, suggested by the lower heart rates and the tendency to a decrease in PNE, is a likely explanation for the decrease in PRA. However, despite this decrease, PA I, PA II, and PAC were not significantly changed after training; the reason for this disrepancy is unknown.read more
Citations
More filters
Journal ArticleDOI
Exercise training lowers resting renal but not cardiac sympathetic activity in humans.
Ian T. Meredith,Peter Friberg,Garry L. Jennings,Elizabeth M Dewar,Virginia A. Fazio,Gavin Lambert,Murray D. Esler +6 more
TL;DR: The magnitude of the fall in renal vascular resistance is insufficient to directly account for the blood pressure-lowering effect of exercise, although other effects of inhibition of the renal sympathetic outflow may be important.
Journal ArticleDOI
Mortality, cardiac vagal control and physical training — what's the link?
TL;DR: If the mechanism of increase in cardiac vagal activity with training can be determined it may be possible to use pharmacological approaches to mimic the effects of exercise with potentially beneficial effects.
Journal ArticleDOI
Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure
TL;DR: Data suggest that multiple central and peripheral influences dynamically alter AT(1)R expression in CHF, and the newly discovered catabolic enzyme angiotensin-converting enzyme 2 (ACE2) may play a role in the modulation of AT( 1)Rexpression by altering the balance between the octapeptide ANG II and ANG- (1-7).
Journal ArticleDOI
Heart rate variability in myocardial infarction patients: Effects of exercise training
Nórton Luís Oliveira,Fernando Ribeiro,Alberto Jorge Alves,Madalena Teixeira,Fátima Miranda,José Oliveira +5 more
TL;DR: Despite conflicting evidence, exercise training appears to be a useful therapeutic intervention to improve the unbalanced autonomic function of MI patients and the possible mechanisms involved are not yet well understood.
Journal ArticleDOI
Angiotensin II--nitric oxide interactions in the control of sympathetic outflow in heart failure.
Irving H. Zucker,Jun Li Liu +1 more
TL;DR: A large number of studies which have concentrated on the mechanisms of sympatho-excitation in heart failure conclude that one mechanism which is important in regulating sympathetic outflow in this disease state depends upon a central interaction between Ang II and NO at the cellular and nuclear levels.
References
More filters
Journal ArticleDOI
The Renin-Angiotensin System
I A Reid,B J Morris,W F Ganong +2 more
TL;DR: Through these actions, the renin-angiotensin system plays an im portant role in the regulation of blood pressure and of the volume and composition of the extracellular fluid.
Journal ArticleDOI
A simplified radiometric assay for plasma norepinephrine and epinephrine.
Philip G. Passon,Jacob D. Peuler +1 more
TL;DR: The plasma norepinephrine and epinephrine assay, when compared to currently available methods, provides a substantial decrease in the assay time while providing a 10-fold increase in sensitivity which allows the analysis to be performed on 0.75 ml or less of plasma.
Journal ArticleDOI
Multiple hormonal responses to prolonged exercise in relation to physical training.
Louise Hartley,John W. Mason,R P Hogan,Leeroy G. Jones,Theodore A. Kotchen,Edward H. Mougey,F E Wherry,L L Pennington,P T Ricketts +8 more
Journal Article
[Renin-angiotensin system].
TL;DR: Investigations for the three-dimensional structure of human and mouse renins showed that the active site cleft had a less open arrangement in renins than that in other aspartic proteinases, although the general topology of both renins were quite similar.
Journal ArticleDOI
The renin-angiotensin system (first of two parts).
Suzanne Oparil,Edgar Haber +1 more
TL;DR: The role of the kidney in blood-pressure regulation was established by TIGERSTEDT and Bergman at the close of the 19th century as discussed by the authors, who produced hypertension in dogs by injecting a cr...