Journal ArticleDOI
Influences of Dietary Restriction on Immunity to Influenza in Aged Mice
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TLDR
It is reported that DR significantly inhibited the age-related decline in antigen presentation and T-cell proliferation and reduced the decline in antibody production to the virus, the first demonstration of improved immunity to an actual infectious agent resulting from DR.Abstract:
Our previous studies of the immune response of aged mice inoculated with influenza A virus revealed age-related decreases in antigen-specific cytotoxic T-lymphocyte function (CTL), T-cell proliferation, IL-2 production, antigen presentation, and antibody production. Because dietary restriction (DR) of rodents has been shown to extend maximum life span, delay the onset of tumors, and improve many immunologic parameters in aged animals, we tested the effect of such a regimen on the immune response to the influenza virus. We report that DR significantly inhibited the age-related decline in antigen presentation and T-cell proliferation. It also reduced the decline in antibody production to the virus. This is the first demonstration of improved immunity to an actual infectious agent resulting from DR. The improvement appears to be on a number of levels and to reflect more than one operative mechanism.read more
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Immunity to influenza in the elderly.
TL;DR: Evidence of immunological senescence in the institutionally confined frail elderly is demonstrated by failure to induce herd immunity after vaccination, and the most convincing evidence is in rodents where dietary caloric restriction has been shown to enhance viral immunity.
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The role of nutrition in enhancing immunity in aging.
TL;DR: The studies published thus far describe a critical role for nutrition in maintaining the immune response of the aged, but they also indicate the need for a more in-depth, wholestic approach to determining the optimal nutritional strategies that would maintain a healthy immune system in the elderly and promote their resistance to infection and other immune-related diseases.