Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase
Sahar El-Mekkawy,Meselhy R. Meselhy,Ines Tomoco Kusumoto,Shigetoshi Kadota,Masao Hattori,Tsuneo Namba +5 more
TLDR
The stereochemistry of 1 was established in this paper by nuclear magnetic resonance spectroscopy and was non-competitive with respect to the substrate but competitive withrespect to a template-primer.Abstract:
Extracts of 41 medicinal plants used in Egyptian folk medicine were screened for their inhibitory effects on human immunodeficiency virus-1 reverse transcriptase. The extracts of fruits of Phyllanthus emblica, Quercus pedunculata, Rumex cyprius, Terminalia bellerica, Terminalia chebula and Terminalia horrida showed significant inhibitory activity with IC50 < or = 50 micrograms/ml. Through a bioassay guided-fractionation of the methanol extract of the fruit of P. emblica, putranjivain A (1) was isolated as a potent inhibitory substance with IC50 = 3.9 microM, together with 1,6-di-O-galloyl-beta-D-glucose (2), 1-O-galloyl-beta-D-glucose (3), kaempferol-3-O-beta-D-glucoside (4), quercetin-3-O-beta-D-glucoside (5) and digallic acid (6). The inhibitory mode of action by 1, 2 and 6 was non-competitive with respect to the substrate but competitive with respect to a template-primer. Furthermore, the stereochemistry of 1 was established in this paper by nuclear magnetic resonance spectroscopy.read more
Citations
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Review on some plants of Indian traditional medicine with antioxidant activity.
Paolo Scartezzini,Ester Speroni +1 more
TL;DR: Seven plants contain antioxidant principles, that can explain and justify their use in traditional medicine in the past as well as the present, and are viewed for their historical, etymological, morphological, phytochemical and pharmacological aspects.
Journal ArticleDOI
Tannins: Classification and Definition
TL;DR: The traditional tanning of animal skins by means of plant tannins has been replaced gradually by mineral tanning, as represented by alum tanning (or glace tanning) and more recently, since the end of the nineteenth century, by chromium tanning.
Journal ArticleDOI
A review of the plants of the genus Phyllanthus: their chemistry, pharmacology, and therapeutic potential.
TL;DR: Together this data strongly supports the view that the plants belonging to the genus Phyllanthus have potential beneficial therapeutic actions in the management of hepatitis B, nefrolitiase, and in painful disorders.
Journal ArticleDOI
Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma Lucidum
Sahar El-Mekkawy,Meselhy R. Meselhy,Norio Nakamura,Yasuhiro Tezuka,Masao Hattori,Nobuko Kakiuchi,Kunitada Shimotohno,Takuya Kawahata,Toru Otake +8 more
TL;DR: A new highly oxygenated triterpene named ganoderic acid alpha has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds by spectroscopic means including 2D-NMR.
Journal ArticleDOI
The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to γ-radiation
TL;DR: Toxicity study showed that triphala was non-toxic up to a dose of 240 mg/kg, where no drug-induced mortality was observed and the optimum protective dose of triphla was 1/28 of its LD50 dose.
References
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Journal ArticleDOI
Inhibition of reverse transcriptases by flavonoids.
TL;DR: Amentoflavone, scutellarein and quercetin were shown to inhibit three reverse transcriptases (RT): avian myeloblastosis (AMV), Rous-associated virus-2 (RAV-2) and Maloney murine leukemia virus (MMLV) as discussed by the authors.
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