Journal ArticleDOI
Inhibitory effects of sudanese medicinal plant extracts on hepatitis C virus (HCV) protease.
Ghazi Hussein,Hirotsugu Miyashiro,Norio Nakamura,Masao Hattori,Nobuko Kakiuchi,Kunitada Shimotohno +5 more
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TLDR
Eight extracts, methanol extracts of Acacia nilotica, Boswellia carterii, Embelia schimperi, Quercus infectoria, Trachyspermum ammi and water extracts of Piper cubeba, Q. infectoria and Syzygium aromaticum were the most active.Abstract:
One hundred fifty-two methanol and water extracts of different parts of 71 plants commonly used in Sudanese traditional medicine were screened for their inhibitory effects on hepatitis C virus (HCV) protease (PR) using in vitro assay methods. Thirty-four extracts showed significant inhibitory activity (>/=60% inhibition at 100 microg/mL). Of these, eight extracts, methanol extracts of Acacia nilotica, Boswellia carterii, Embelia schimperi, Quercus infectoria, Trachyspermum ammi and water extracts of Piper cubeba, Q. infectoria and Syzygium aromaticum, were the most active (>/=90% inhibition at 100 microg/mL). From the E. schimperi extract, two benzoquinones, embelin (I) and 5-O-methylembelin (II), were isolated and found as potent HCV-PR inhibitors with IC(50) values of 21 and 46 microM, respectively. Inhibitory activities of derivatives of I against HCV-PR as well as their effects on other serine proteases were also investigated.read more
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The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review.
Kamel Chaieb,Hafedh Hajlaoui,Tarek Zmantar,Amel Ben Kahla-Nakbi,Mahmoud Rouabhia,Kacem Mahdouani,Amina Bakhrouf +6 more
TL;DR: The chemical composition and biological effects of clove essential oil are addressed, and new results from GC/MS analysis and a study of its antimicrobial activity against a large number of multi‐resistant Staphylococcus epidermidis isolated from dialysis biomaterials are included.
Journal ArticleDOI
Novel antiviral agents: a medicinal plant perspective
Sabah A. A. Jassim,M. A. Naji +1 more
TL;DR: There are innumerable potentially useful medicinal plants and herbs waiting to be evaluated and exploited for therapeutic applications against genetically and functionally diverse viruses families such as Retroviridae, Hepadnaviridae and Herpesviridae.
Journal ArticleDOI
Antiviral Potentials of Medicinal Plants
Muhammad Mukhtar,Mohammad Arshad,Mahmood Ahmad,Roger J. Pomerantz,Brian Wigdahl,Zahida Parveen +5 more
TL;DR: Potential antiviral properties of medicinal plants against a diverse group of viruses are described, and screening the potential of plants possessing broad-spectrum antiviral effects against emerging viral infections is suggested.
Research Paper - The potential of aqueous and acetone extracts of galls of Quercus infectoria as antibacterial agents
D. F. Basri,S. H. Fan +1 more
TL;DR: The aqueous and acetone extracts displayed similarities in their antimicrobial activity on the bacterial species and as such, the galls of Quercus infectoria are potentially good source of antimicrobial agents.
Journal ArticleDOI
Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities.
Gaber El-Saber Batiha,Luay Alkazmi,Lamiaa Wasef,Amany Magdy Beshbishy,Eman H. Nadwa,Eman K. Rashwan +5 more
TL;DR: The phytochemical composition and biological activities of clove extracts along with clove essential oil and the main active compound, eugenol, are examined and implicates new findings from gas chromatography-mass spectroscopy (GC-MS) analysis.
References
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Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins.
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The long term efficacy of glycyrrhizin in chronic hepatitis C patients
Yasuji Arase,Kenji Ikeda,Naoya Murashima,Kazuaki Chayama,Akihito Tsubota,Isao Koida,Yoshiyuki Suzuki,Satoshi Saitoh,Masahiro Kobayashi,Hiromitsu Kumada +9 more
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Demonstration of in vitro infection of chimpanzee hepatocytes with hepatitis C virus using strand-specific RT/PCR.
TL;DR: Two new methods of reverse transcription/polymerase chain reaction were developed that permit accurate distinction between positive and negative strand HCV RNA in chimpanzee hepatocytes, and could be amenable to the study of HCV replication, antiviral compounds, and the development of neutralization assays.