Insulin resistance and early virological response in chronic HCV infection
Wafaa M. Ezzat,Yasser A. Elhosary,Nour A. Abdulla,Hala M. Raslan,Omneya M. Saleh,Mona H. Ibrahim,Maha A. Rasheed,H. El-Hariri +7 more
TLDR
Insulin resistance is a common finding in CHC, it is associated with increase liver steatosis, however it has no impact on EVR to combined interferon ribavirin therapy, viral load or necroinflammation.About:
This article is published in Journal of Genetic Engineering and Biotechnology.The article was published on 2013-06-01 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Liver biopsy & Insulin resistance.read more
Citations
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Journal ArticleDOI
Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection
Iman Ibrahim Salama,Hala M. Raslan,Ghada A. Abdel-Latif,Somaia I Salama,Samia M. Sami,Fatma A. Shaaban,Aida Abdelmohsen,Walaa A. Fouad +7 more
TL;DR: Early therapeutic approach with DAAs is recommended as it cure many of the EHMs that are still in a reversible stage and can prevent others that can develop due to delayed treatment.
Journal ArticleDOI
Evaluating the Effects of Anti-Viral Therapy on Insulin Resistance and Diabetic Status in Chronic Hepatitis C patients
Gamal Ahmed Tawfeek,Abd El-Raoof El-Deib,Fadia M. Attia,Nader El-Nemr,Asmaa Salman Faisal,Ahmed S Faisal +5 more
TL;DR: Evaluation of direct acting anti-viral therapy effect on insulin resistance (IR) and glycemic status in CHC patients with type 2 diabetes mellitus, 3 months after the end of treatment found a significant improvement in FBS as well as IR was declared after successful HCV treatment.
Journal ArticleDOI
Study of prevalence and effects of insulin resistance in patients with chronic hepatitis C genotype 4.
TL;DR: It is confirmed that insulin resistance affects treatment outcome, and thus HOMA-IR testing before initiation of therapy may be a cost-effective tool.
References
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Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Journal ArticleDOI
Histological grading and staging of chronic hepatitis.
Kamal G. Ishak,Amelia Baptista,Leonardo Bianchi,Francesco Callea,Jan De Groote,Fred Gudat,Helmut Denk,Valeer Desmet,Gerhard Korb,R. N. M. Macsween,M. James Phillips,Bernard G. Portmann,H. Poulsen,Peter J. Scheuer,Martin Schmid,Heribert Thaler +15 more
TL;DR: This research presents a meta-analysis of Anatomia e Istologia Patologica, a large quantity of which has never before been published in a peer-reviewed journal, which aims to provide real-time information about the immune system’s response to disease.
Journal ArticleDOI
Nonalcoholic steatohepatitis: definition and pathology.
TL;DR: A histological "grading and staging" system has been developed to reflect the unique features of steatohepatitis, gradations of severity and fibrosis, and to promote uniform reporting of the histopathology.
Journal ArticleDOI
Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Enzo Bonora,Stefan Kiechl,Johann Willeit,Friedrich Oberhollenzer,Georg Egger,Giovanni Targher,Maria Alberiche,Riccardo C. Bonadonna,Michele Muggeo +8 more
TL;DR: Results from a population-based study documented that in hypertriglyceridemia and a low HDL cholesterol state, insulin resistance is as common as in NIDDM, whereas it is less frequent in hypercholesterolemia, hyperuricemia, and hypertension.
Journal ArticleDOI
Insulin resistance: A metabolic pathway to chronic liver disease†
TL;DR: The ability of insulin‐sensitizing, pharmacological agents to treat NAFLD by reducing IR in the liver (metformin) and in the periphery (thiazolidinediones) are discussed.