Journal ArticleDOI
Interactions between mammalian cell DNA and inorganic platinum compounds. I. DNA interstrand cross-linking and cytotoxic properties of platinum(II) compounds.
Janet M. Pascoe,John J. Roberts +1 more
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TLDR
In this paper, the effects of cis and trans Pt(II)-diammine dichloride on the colony forming ability of HeLa cells have been measured, showing that more of the trans compound was bound to DNA than cis when cell survival was reduced by the same amount, suggesting there was a real difference in the mechanisms of action of the two isomers.About:
This article is published in Biochemical Pharmacology.The article was published on 1974-05-01. It has received 143 citations till now. The article focuses on the topics: DNA & Cis–trans isomerism.read more
Citations
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Mechanisms of Cisplatin nephrotoxicity.
TL;DR: Recent advances in understanding of cisplatin nephrotoxicity are summarized and it is discussed how these advances might lead to more effective prevention.
Journal ArticleDOI
The role of the unfolded protein response in tumour development: friend or foe?
Yanjun Ma,Linda M. Hendershot +1 more
TL;DR: Recent delineation of the components of this response indicate that it is uniquely poised to have a role in regulating the balance between cancer cell death, dormancy and aggressive growth, as well as altering the sensitivity of solid tumours to chemotherapeutic agents.
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Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions.
Rossella Marullo,Erica Werner,Natalya Degtyareva,Bryn S. Moore,Giuseppe Altavilla,Suresh S. Ramalingam,Paul W. Doetsch +6 more
TL;DR: Exposure to cisplatin induces a mitochondrial-dependent ROS response that significantly enhances the cytotoxic effect caused by nDNA damage and may lead to the design of novel therapeutic strategies to improve anticancer drug efficacy.
Journal ArticleDOI
Platinum(IV) antitumour compounds: their bioinorganic chemistry
TL;DR: A review of the investigations undertaken into platinum-IV antitumour compounds since Barnett Rosenberg first noted the activity of platinum(IV) complexes is given in this article. But the bioinorganic chemistry of these compounds has not previously been reviewed, and the purpose here is to provide insight into the requirements for the antitumours activity of these complexes.
Journal ArticleDOI
Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer
TL;DR: The role of this protein in cancer development and progression is focused on, highlighting the potential role of the mitogen-activated protein kinase (MAPK) family, and an integrated scheme for MKP-1 and MAPK in cancer is proposed.
References
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Journal ArticleDOI
Platinum Compounds: a New Class of Potent Antitumour Agents
TL;DR: The platinum compounds inhibit sarcoma 180 and leukaemia L1210 in mice and reversibly inhibit cell division in Gram-negative rods1–4.
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The Inhibition of Growth or Cell Division in Escherichia coli by Different Ionic Species of Platinum(IV) Complexes
TL;DR: The cis and trans forms of the diamino complex, [PtCl4(NH3)2]0, have been synthesized and the electrophoretic patterns indicate predominantly neutral species in both cases.
Journal ArticleDOI
Inhibitory effects of anti-tumor platinum compounds on DNA, RNA and protein syntheses in mammalian cells in virtro.
TL;DR: A number of possible explanations for the greater sensitivity of DNA synthesis and the sequential inhibition of DNA, RNA and protein synthesis at higher concentrations are suggested.
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Cis-dichlorodiammineplatinum (II). Persistent and selective inhibition of deoxyribonucleic acid synthesis in vivo.
Jerry A. Howle,Glen R. Gale +1 more
TL;DR: It was suggested that if the persistent inhibitory action on DNA synthesis is directly related to the chemotherapeutic efficacy of this agent or a metabolic product thereof, a less frequent treatment regimen may be as effective as daily injections while evoking fewer toxic reactions.
Journal ArticleDOI
Molecular mechanism of the cytotoxic action of difunctional alkylating agents and of resistance to this action.
P. D. Lawley,Peter Brookes +1 more
TL;DR: Molecular Mechanism of the Cytotoxic Action of Difunctional Alkylating Agents and of Resistance to this Action are studied.
Related Papers (5)
Interactions between mammalian cell DNA and inorganic platinum compounds. II. Interstrand cross-linking of isolated and cellular DNA by platinum(IV) compounds.
Janet M. Pascoe,John J. Roberts +1 more