Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor.
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TLDR
It is shown by mRNA analysis that an immortalized line of human endothelial cells constitutively produce granulocyte-macrophage colony-stimulating factor, and interleukin 1 and tumor necrosis factor induce early passage human umbilical endothelium cells to produce the same growth factor.Abstract:
Monokine-stimulated endothelial cells are known to produce both burst- and colony-stimulating activities, but neither the nature of the monokine nor the hematopoietic growth factor(s) produced is known. We show by mRNA analysis that an immortalized line of human endothelial cells constitutively produce granulocyte-macrophage colony-stimulating factor. Furthermore, interleukin 1 and tumor necrosis factor induce early passage human umbilical endothelial cells to produce the same growth factor.read more
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The human hematopoietic colony-stimulating factors
Steven C. Clark,Robert Kamen +1 more
TL;DR: These advances have led to a much better understanding of the role of the myeloid growth factors in regulating hematopoiesis in vivo that should soon find practical application in clinical medicine.
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Molecular physiology of granulocyte-macrophage colony-stimulating factor.
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Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate.
Federico Bussolino,Ji Ming Wang,Paola Defilippi,Franco Turrini,Fiorella Sanavio,C.-J. S. Edgell,Massimo Aglietta,Paolo Arese,Alberto Mantovani +8 more
TL;DR: It is reported that G-CSF and GM- CSF influence the migration and proliferation of human endothelial cells suggesting that these molecules may act as regulatory signals outside the haematopoietic system.
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Hematopoietic growth factors.
TL;DR: Recombinant purified HGFs have been used to investigate their functions in vitro, the binding characteristics of their receptors, and the isolation of certain receptor cDNAs.
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Regulation of myeloid development and function by colony stimulating factors.
TL;DR: Although most of available knowledge about CSFs is on human and mouse CSFs, an attempt was made to integrate recent findings in other systems in order to highlight a more widespread role for CSFs throughout evolution.
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