Journal ArticleDOI
Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
José V. Castell,María José Gómez-Lechón,Martina David,Tilo Andus,Thomas Geiger,Ramón Trullenque,Ricardo Fabra,Peter C. Heinrich +7 more
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The data suggest that IL‐6 plays the key role in the regulation of acute phase protein synthesis in human hepatocytes.About:
This article is published in FEBS Letters.The article was published on 1989-01-02. It has received 828 citations till now. The article focuses on the topics: Acute-phase protein & Serum amyloid A.read more
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Interleukin-6 and the acute phase response
TL;DR: Systemic reaction characterized by fever, leukocytosis, increase in erythrocyte sedimentation rate, increases in LeucocyTosis secretion of ACTH and glucocorticoids, and by dramatic changes in the concentration of some plasma ,l' proteins.
Journal ArticleDOI
Extrapulmonary manifestations of COVID-19.
Aakriti Gupta,Aakriti Gupta,Mahesh V. Madhavan,Kartik Sehgal,Kartik Sehgal,Nandini Nair,Shiwani Mahajan,Tejasav S. Sehrawat,Behnood Bikdeli,Behnood Bikdeli,Neha Ahluwalia,John C. Ausiello,Elaine Wan,Daniel E. Freedberg,Ajay J. Kirtane,Sahil A. Parikh,Mathew S. Maurer,Anna S. Nordvig,Domenico Accili,Joan M. Bathon,Sumit Mohan,Kenneth A. Bauer,Kenneth A. Bauer,Martin B. Leon,Harlan M. Krumholz,Nir Uriel,Mandeep R. Mehra,Mitchell S.V. Elkind,Mitchell S.V. Elkind,Gregg W. Stone,Allan Schwartz,David D. Ho,John P. Bilezikian,Donald W. Landry +33 more
TL;DR: The extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 are reviewed to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for all organ systems involved.
Journal ArticleDOI
Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases
TL;DR: Animal experiments and clinical intervention studies indicate that omega-3 fatty acids have anti-inflammatory properties and, therefore, might be useful in the management of inflammatory and autoimmune diseases.
Journal ArticleDOI
Inflammatory response to cardiopulmonary bypass
TL;DR: Understanding of the interactions between these markers of cellular and humoral responses to cardiopulmonary bypass will enable more effective intervention to reduce the deleterious effects and improve the outlook for patients undergoing cardiac operations beyond the 1990s.
Journal ArticleDOI
Serum amyloid A, the major vertebrate acute-phase reactant.
TL;DR: Although the precise role of A-SAA in host defense during inflammation has not been defined, many potential clinically important functions have been proposed for individual SAA family members, including involvement in lipid metabolism/transport, induction of extracellular-matrix-degrading enzymes, and chemotactic recruitment of inflammatory cells to sites of inflammation.
References
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Journal ArticleDOI
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
Toshio Hirano,Kiyoshi Yasukawa,Hisashi Harada,Tetsuya Taga,Yasuo Watanabe,Tadashi Matsuda,Shin-ichiro Kashiwamura,Koichi Nakajima,Koichi Koyama,Akihiro Iwamatsu,Susumu Tsunasawa,Fumio Sakiyama,Hiroshi Matsui,Yoshiyuki Takahara,Tadatsugu Taniguchi,Tadamitsu Kishimoto +15 more
TL;DR: The molecular cloning, structural analysis and functional expression of the cDNA encoding human B SF-2 indicated that BSF-2 is functionally and structurally unlike other known proteins.
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Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells
TL;DR: It is demonstrated that monocyte-derived hepatocyte-stimulating factor and IFN-beta 2 share immunological and functional identity and that IFN -beta 2, also known as B-cell stimulatory factor and hybridoma plasmacytoma growth factor, has the hepatocyte as a major physiologic target and thereby is essential in controlling the hepatic acute phase response.
Journal ArticleDOI
Interleukin-1 and the pathogenesis of the acute-phase response.
TL;DR: The full spectrum of the response includes dramatic increases in the synthesis of hepatic acute-phase proteins, which contribute to elevated erythrocyte-sedimentation rates.
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Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.
TL;DR: The monokine, cachectin/tumor necrosis factor differs from interleukin 1 in primary structure and in recognition by a distinct cellular receptor, and the possibility that recombinant-generated human TNF regulates hepatic acute-phase gene expression was examined.
Journal ArticleDOI
Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes.
José V. Castell,María José Gómez-Lechón,Martina David,Toshio Hirano,Tadamitsu Kishimoto,Peter C. Heinrich +5 more
TL;DR: It is concluded that rhIL‐6 controls the acute phase response in human liver cells.