International collaborative research for pediatric and neonatal lung injury: the example of an ESPNIC initiative to validate definitions and formulate future research questions
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TLDR
The European Society for Pediatric and Neonatal Intensive Care (ESPNIC), together with some members of the original ARDS Task Force, have set up an international collaborative project to validate the new Berlin definition for infants and toddlers.Abstract:
An interesting review of acute respiratory distress (ARDS) definitions has been recently published in the Jornal de Pediatria, focusing on actual needs in terms of research and clinical care of pediatric ARDS. Unfortunately, timing prevented the consideration of an important step forward in this field. The European Society for Pediatric and Neonatal Intensive Care (ESPNIC), together with some members of the original ARDS Task Force, have set up an international collaborative project to validate the new Berlin definition for infants and toddlers. This project is the first initiative linking different pediatric intensive care units (PICU) in order to reach enough statistical power to address a specific research need. Figure 1 shows the ESPNIC net for this project. Indeed, as Fioretto et al. summarized, no specific pediatric validation had ever been conducted, even though some children were included in the original ARDS definition proposed by Ashbaugh et al. in 1967. Fioretto et al. described several possible limitations of the Berlin definition: however, some of the points raised by these authors should not be considered as a limitation, since the new Berlin definition is not supposed to be a predictive tool, but rather a framework to define a syndrome for epidemiology, clinical care, and research.read more
Citations
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Epidemiology and outcomes of acute respiratory distress syndrome in children according to the Berlin definition: a multicenter prospective study.
Eliane Roseli Barreira,Gabriela Ortega Cisternas Muñoz,Priscilla de Oliveira Cavalheiro,Adriana Stama Suzuki,Natalia Viu Degaspare,Huei Hsin Shieh,João Augusto dos Santos Martines,Juliana Carvalho Ferreira,Christianne Lane,Werther Brunow de Carvalho,Alfredo Elias Gilio,Alexander Roberto Precioso +11 more
TL;DR: The Berlin definition can identify a subgroup of patients with distinctly worse outcomes, as shown by the increased mortality and reduced number of ventilator-free days in pediatric patients with severe acute respiratory distress syndrome.
Journal ArticleDOI
Progress and perspectives in pediatric acute respiratory distress syndrome
Alexandre T. Rotta,Jefferson Pedro Piva,Cinara Andreolio,Werther Brunow de Carvalho,Pedro Celiny Ramos Garcia +4 more
TL;DR: Recommendations for the implementation of mechanical ventilation strategies in the treatment of acute respiratory distress syndrome in children and the use of adjuvant therapies are discussed.
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How to manage ventilation in pediatric acute respiratory distress syndrome
Journal ArticleDOI
ARDS definitions in children: one step forward
ARDS definitions in children: one step forward
TL;DR: enrolled 221 children, medianage 6 months (range 2-13 months), which were categorized according to the two definitions, and the authors found veryinteresting and important results.
References
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Evaluating the Berlin Definition in pediatric ARDS
Robinder G. Khemani,Robinder G. Khemani,Douglas F. Wilson,Andrés Esteban,Niall D. Ferguson,Niall D. Ferguson +5 more