Interrelations between COVID-19 and other disorders.
Amin Gasmi,Massimiliano Francesco Peana,Lyudmila Pivina,Shvetha Srinath,Asma Gasmi Benahmed,Yuliya Semenova,Alain Menzel,Maryam Dadar,Geir Bjørklund +8 more
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TLDR
This review intends to understand how some of these comorbidities affect the disease’s prognosis and how severe the outcome can be expected.About:
This article is published in Clinical Immunology.The article was published on 2021-03-01 and is currently open access. It has received 88 citations till now. The article focuses on the topics: Disease & Sore throat.read more
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
Early cross-coronavirus reactive signatures of humoral immunity against COVID-19.
Paulina Kaplonek,Chuangqi Wang,Yannic C. Bartsch,Stephanie Fischinger,Matthew J. Gorman,Kathryn Bowman,Jaewon Kang,Diana Dayal,Patrick Martin,Radosław P. Nowak,Alexandra-Chloé Villani,Ching-Lin Hsieh,Nicole C. Charland,Anna L.K. Gonye,Anna L.K. Gonye,Irena Gushterova,Irena Gushterova,Hargun K. Khanna,Thomas J. LaSalle,Thomas J. LaSalle,Kendall M. Lavin-Parsons,Brendan M. Lilley,Carl L. Lodenstein,Kasidet Manakongtreecheep,Kasidet Manakongtreecheep,Justin D. Margolin,Brenna N. McKaig,Maricarmen Rojas-Lopez,Brian C. Russo,Nihaarika Sharma,Nihaarika Sharma,Jessica Tantivit,Jessica Tantivit,Molly Thomas,Moshe Sade-Feldman,Moshe Sade-Feldman,Jared Feldman,Boris Julg,Eric J. Nilles,Elon R. Musk,Anil S. Menon,Eric S. Fischer,Jason S. McLellan,Aaron G. Schmidt,Marcia B. Goldberg,Michael R. Filbin,Michael R. Filbin,Nir Hacohen,Nir Hacohen,Douglas A. Lauffenburger,Galit Alter +50 more
TL;DR: The introduction of vaccines has inspired hope in the battle against SARS-CoV-2. However, the emergence of viral variants, in the absence of potent antivirals, has left the world struggling with th...
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Effects of SARS-CoV-2 on Cardiovascular System: The Dual Role of Angiotensin-Converting Enzyme 2 (ACE2) as the Virus Receptor and Homeostasis Regulator-Review.
Aneta Aleksova,Giulia Gagno,Gianfranco Sinagra,Antonio Paolo Beltrami,Milijana Janjusevic,Giuseppe Ippolito,Alimuddin Zumla,Alessandra Lucia Fluca,Federico Ferro +8 more
TL;DR: In this article, the effects of different COVID-19 vaccines on ACE2 in patients on treatment with ACEi/ARB were studied, and it was shown that patients with CVDs have a higher mortality rate, which was likely driven by the imbalance between ADAM metallopeptidase domain 17 (ADAM17) protein (which is required for cleavage of ACE-2 ectodomain resulting in increased ACE2 shedding), and TMPRSS2 (which was required for spike glycoprotein priming).
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Long-term follow-up of dynamic brain changes in patients recovered from COVID-19 without neurological manifestations
Tian Tian,Jinfeng Wu,Tao Chen,Jia Li,Su Yan,Yiran Zhou,Xiaolong Peng,Yuanhao Li,Ning Zheng,Aoling Cai,Qin Ning,Hong-Bing Xiang,Fu Xu,Yuanyuan Qin,Wenzhen Zhu,Jie Wang +15 more
TL;DR: This study provides objective neuroimaging evidence for the coexistence of recoverable and long-term unrecovered changes in 10-month effects of COVID-19 on the brain.
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A SARS-CoV-2 -human metalloproteome interaction map.
Christos T. Chasapis,Athanasia K. Georgiopoulou,Spyros P. Perlepes,Geir Bjørklund,Massimiliano Francesco Peana +4 more
TL;DR: Zhang et al. as discussed by the authors found that most human metalloproteins interact with the recently discovered SARS-CoV-2 orf8 protein, whose antibodies are one of the principal markers of SARS CoV2 infections.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
Journal ArticleDOI
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.