Journal ArticleDOI
Investigation of bioactivities of methanolic and ethyl acetate extracts of Dioscorea pentaphylla leaf along with its phenolic composition
Milon Mondal,Milon Mondal,Md. Monir Hossain,Md. Monir Hossain,Nittananda Das,Mohammad Asikur Rahman,Nizam Uddin,Md. Rakib Hasan,Md. Jahir Alam,Md. Nurul Islam,Tania Binte Wahed,Sukalyan Kumar Kundu +11 more
TLDR
In this article, the authors investigated the in-vivo antioxidant properties, brine shrimp lethality bioassay, and antimicrobial activity and invivo analgesic, anti-inflammatory, and antidiarrheal potentiality of methanolic and ethyl acetate extracts of Dioscorea pentaphylla.Abstract:
The present study was performed to investigate the in-vitro antioxidant properties, brine shrimp lethality bioassay, and antimicrobial activity and in-vivo analgesic, anti-inflammatory, and antidiarrheal potentiality of methanolic and ethyl acetate extracts of Dioscorea pentaphylla (D. pentaphylla) leaf along with determining the bioactive phenolic compounds by HPLC analysis. Standard methods were used to investigate the aforementioned bioactivities. Methanol extract showed higher total phenolic activity, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and Nitric oxide (NO) radical scavenging activities, whereas ethyl acetate extract showed better activities in total flavonoid and total antioxidant capacity assays. Dose-dependent moderate reducing capacity was observed for both extracts in cupric reducing and reducing power capacity assays. The methanol extract was found to be more potent than ethyl acetate extract according to brine shrimp lethality bioactivity test. Both extracts exhibited broad-spectrum antimicrobial activity in the disk diffusion method. In tail immersion test, at 1000 mg/kg dose, both extracts of D. pentaphylla showed a significant (p < 0.05) reduction in pain sensation. Ethyl acetate extract has significantly (p < 0.05) decreased writhing of the tested mice which were induced by acetic acid. The number of licks in formalin-induced paw licking test was markedly (p < 0.05) lessened in both extracts administration. Ethyl acetate extract revealed better anti-inflammatory activities than methanol extract in two well-known anti-inflammatory models (Xylene-induced ear edema, Cotton pellet-induced granuloma formation). Methanol extract displayed potent anti-diarrheal activity. HPLC analysis confirmed the existence of phenolic compounds (gallic acid, rutin, and quercetin) in the leaf extract of D. pentaphylla. These phytochemical constituents might have the role in the observed activities.read more
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Hepatoprotective and antioxidant activities of Justicia gendarussa leaf extract in carbofuran-induced hepatic damage in rats
Milon Mondal,Milon Mondal,Md. Monir Hossain,Mohammad Asikur Rahman,Sushmita Saha,Nizam Uddin,Md. Rakib Hasan,Abdul Kader,Tania Binte Wahed,Sukalyan Kumar Kundu,Muhammad Torequl Islam,Mohammad S. Mubarak +11 more
TL;DR: The present study suggests the protective role of JgMe against hepatic injury induced by CF which may be attributed to its higher antioxidant properties and thereby scientifically justifies its traditional use.
Journal ArticleDOI
Therapeutic perspectives of the black cumin component thymoquinone: A review
Chandan Kumar Sarkar,Sarmin Jamaddar,Tawhida Islam,Milon Mondal,Muhammad Torequl Islam,Mohammad S. Mubarak +5 more
TL;DR: A review of the most recent literature pertaining to the use of TQ for the prevention and treatment of various diseases along with possible mechanisms of action, and the potential use of this natural product as a complementary or alternative medicine is presented in this paper.
Journal ArticleDOI
Dioscorea spp.: Comprehensive Review of Antioxidant Properties and Their Relation to Phytochemicals and Health Benefits
TL;DR: A comprehensive survey of the published articles has revealed that the majority of studies have been performed with plant tubers (rhizomes, roots), while reports on leaves are rather scarce as discussed by the authors .
Journal ArticleDOI
Phytochemical profiling and evaluation of bioactivities of methanolic and ethyl acetate extracts of Marsdenia tenacissima leaves
Milon Mondal,Sushmita Saha,Md. Monir Hossain,Islam Al Foyjul,Chandan Kumar Sarkar,Md. Solayman Hossain,Abul Bashar Ripon Khalipha,Sukalyan Kumar Kundu +7 more
TL;DR: The in vitro antioxidant properties, brine shrimp lethality bioassay, in vivo analgesic, anti-inflammatory, and anti-diarrheal potentiality of methanolic and ethyl acetate extracts of leaf of Marsd...
Journal ArticleDOI
Analgesic and Anti-Inflammatory Potential of Essential Oil of Eucalyptus camaldulensis Leaf: In Vivo and in Silico Studies
Milon Mondal,Cristina Quispe,Chandan Kumar Sarkar,Tapash Chandra Bepari,Md. Jahir Alam,Sushmita Saha,Pranta Ray,Mohammod Abdur Rahim,Muhammad Torequl Islam,William N. Setzer,Bahare Salehi,Mehdi Ahmadi,Mohnad Abdalla,Javad Sharifi-Rad,Sukalyan Kumar Kundu +14 more
TL;DR: In this article, the authors scrutinize the analgesic and anti-inflammatory potentials of essential oil of Eucalyptus camaldulensis leaf using different in vivo assay models at doses of...
References
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Phytochemistry and Therapeutic Potential of Medicinal Plant: Dioscorea bulbifera
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Journal ArticleDOI
DNA Damage Inhibition Properties of Sundarban Honey and its Phenolic Composition
Rizwana Afroz,E. M. Tanvir,Sudip Paul,Nikhil Chandra Bhoumik,Siew Hua Gan,Md. Ibrahim Khalil +5 more
TL;DR: Sundarban honey is one of the most renowned and popular types of honey from Bangladesh as mentioned in this paper, which can provide a very good source of natural antioxidant which particularly contains some phenolic compounds including gallic, vanillic and trans-Cinnamic acids as well as three flavonoids (naringin, rutin and quercetin).