Journal ArticleDOI
Hepatoprotective and antioxidant activities of Justicia gendarussa leaf extract in carbofuran-induced hepatic damage in rats
Milon Mondal,Milon Mondal,Md. Monir Hossain,Mohammad Asikur Rahman,Sushmita Saha,Nizam Uddin,Md. Rakib Hasan,Abdul Kader,Tania Binte Wahed,Sukalyan Kumar Kundu,Muhammad Torequl Islam,Mohammad S. Mubarak +11 more
TLDR
The present study suggests the protective role of JgMe against hepatic injury induced by CF which may be attributed to its higher antioxidant properties and thereby scientifically justifies its traditional use.Abstract:
In folk medicines, Justicia gendarussa (J. gendarussa) is used as a depurative herb for treating fever, pain, and cancer and as laxative for constipation. The aim of the present investigation was to evaluate the hepatoprotective effect of the leaf methanol extract of J. gendarussa leaf (J gMe) against carbofuran (CF)-intoxicated liver injuries in Sprague-Dawley rats, along with the antioxidant activity of this extract. For this purpose, levels of serum diagnostic markers, hepatic antioxidant enzymes, and liver histo-architecture were employed to justify the protective efficacy of J gMe. In addition, the phenolic and flavonoid contents of the extract were quantified, and antioxidant activity was investigated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide, hydrogen peroxide, and hydroxyl free radical scavenging assays. Results revealed that the leaf extract caused a significant (<0.05, <0.01) decrease of the level of hepatic enzymes, triglycerides, and bilirubin and an increase of the total protein. J gMe has also significantly (<0.05, <0.01) lowered the level of malonylaldehyde. Carbofuran markedly suppressed hepatic antioxidant enzymes, however, the leaf extract significantly augmented these enzymes. The hepatoprotective effect was demonstrated by the improvement in the histo-architectural features of liver sections of CF-intoxicated rats treated with J gMe at 500 mg/kg dose. In addition, J gMe showed moderate total phenolic and total flavonoid content, whereas the IC50 values of DPPH, nitric oxide, hydrogen peroxide, and hydroxyl free radical scavenging assays were 71.31 ± 0.42, 134.82 ± 0.14, 47.69 ± 0.38, and 118.44 ± 0.30 μg/mL, respectively. In conclusion, the present study suggests the protective role of J gMe against hepatic injury induced by CF, which may be attributed to its higher antioxidant properties and thereby scientifically justifies its traditional use.read more
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Medicinal plants used against hepatic disorders in Bangladesh: A comprehensive review
TL;DR: In this article , the authors summarized the processes of hepatotoxicity induced by various toxins and explored identified hepatoprotective plants and their phytoconstituents, which can guide the extraction of novel phytochemical constituents from plants to treat liver injury.
Journal ArticleDOI
Medicinal plants used against hepatic disorders in Bangladesh: A comprehensive review.
Rajib Das,Saikat Mitra,Abu Montakim Tareq,Talha Bin Emran,Md. Jamal Hossain,Ali Alqahtani,Yahia Alghazwani,Kuldeep Dhama,Jesus Simal-Gandara +8 more
TL;DR: In this paper, the authors summarized the processes of hepatotoxicity induced by various toxins and explored identified hepatoprotective plants and their phytoconstituents, which can guide the extraction of novel phytochemical constituents from plants to treat liver injury.
Journal ArticleDOI
Antibacterial activity and photocatalytic dye degradation of copper oxide nanoparticles (CuONPs) using Justicia gendarussa
Seerangaraj Vasantharaj,Pooja Shivakumar,Selvam Sathiyavimal,P. Senthilkumar,S. Vijayaram,M. Shanmugavel,Arivalagan Pugazhendhi +6 more
TL;DR: In this article, a facile, non-toxic, and eco-friendly synthesis of biomolecules functionalized copper oxide nanoparticles (CuONPs) using Justicia gendarussa (J.gendrasa) leaf extract was used as a potential capping and stabilising agent for the reduction of copper ions to CuONPs.
Journal ArticleDOI
Effects of nerol on paracetamol-induced liver damage in Wistar albino rats.
Muhammad Torequl Islam,Cristina Quispe,Md. Amirul Islam,Eunüs S. Ali,Sushmita Saha,Umma Hafsa Asha,Milon Mondal,Ahmad Faizal Abdull Razis,Usman Sunusi,Usman Sunusi,Ramla Muhammad Kamal,Manoj Kumar,Javad Sharifi-Rad +12 more
TL;DR: Nerol, a monoterpene is evident to possess diverse biological activities, including antioxidant, anti-microbial, anti spasmodic, anthelmintic, and anti-arrhythmias.
Journal ArticleDOI
Chemical profiling of Justicia vahlii Roth. (Acanthaceae) using UPLC-QTOF-MS and GC-MS analysis and evaluation of acute oral toxicity, antineuropathic and antioxidant activities
TL;DR: In this paper , the authors explored the pain cessation potential of J. vahlii Roth via a murine model of neuropathic pain and its phytochemical, toxicological and antioxidant profiles, and the extract was found nontoxic up to 4000 mg/kg (p.o.) in mice and no mortality observed in brine shrimp lethality assay.
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