Journal ArticleDOI
Involvement of endothelium/nitric oxide in vasorelaxation induced by purified green tea (-)epicatechin.
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TLDR
There may be a causal link between increased Ca2+ levels and nitric oxide release in response to (-)epicatechin, and endothelium-dependent relaxation is primarily mediated by Nitric oxide and partially through iberiotoxin-sensitive K+ channels.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1999-04-19. It has received 94 citations till now. The article focuses on the topics: Nitric oxide & Endothelium.read more
Citations
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A Review of the Health Effects of Green Tea Catechins in In Vivo Animal Models
Vanessa Crespy,Gary Williamson +1 more
TL;DR: Most studies using animal models show that consumption of green tea (catechins) provides some protection, although most studies have not examined dose response and further investigations on mechanisms, the nature of the active compounds, and appropriate dose levels are needed.
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EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR
Maria Assunta Potenza,Flora L. Marasciulo,Mariela Tarquinio,E. Tiravanti,G. Colantuono,Antonio Federici,Jeong-a Kim,Michael J. Quon,Monica Montagnani +8 more
TL;DR: It is concluded that acute actions of EGCG to stimulate production of nitric oxide from endothelium using PI 3-kinase-dependent pathways may explain, in part, beneficial effects of E GCG therapy to simultaneously improve metabolic and cardiovascular pathophysiology in SHR.
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A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation
Mario Lorenz,Silja Wessler,Elena Follmann,Wanda Michaelis,Thomas Düsterhöft,Gert Baumann,Karl Stangl,Verena Stangl +7 more
TL;DR: The results indicate that EGCG-induced endothelium-dependent vasodilation is primarily based on rapid activation of eNOS by a phosphatidylinositol 3-kinase-, PKA-, and Akt-dependent increase in eNos activity, independently of an altered eN OS protein content.
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Molecular targets of tea polyphenols in the cardiovascular system.
TL;DR: More detailed and profound analysis of molecular actions in different cells of the cardiovascular system is necessary before safe clinical use of tea polyphenols for treatment of cardiovascular diseases will become possible.
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The role of tea and tea flavonoids in cardiovascular health.
TL;DR: Overall, tea represents a promising tool for the prevention and treatment of cardiovascular disorders and underlying mechanisms for the beneficial effects of tea include vasculoprotective, antioxidative, antithrombogenic, anti-inflammatory, and lipid-lowering properties of tea flavonoids.
References
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Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
TL;DR: In arterial rings the vasorelaxing actions of the drugs diazoxide, cromakalim, and pinacidil and the hyperpolarizing actions of vasoactive intestinal polypeptide and acetylcholine were blocked by inhibitors of the ATP-sensitive K+ channels, suggesting that all these agents may act through a common pathway in smooth muscle by opening ATP- sensitivity channels.
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Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.
Stephen L. Archer,James M.C. Huang,Vaclav Hampl,Daniel P. Nelson,Pamela J. Shultz,Edward K Weir +5 more
TL;DR: NO and cGMP relax vascular smooth muscle by a cG MP-dependent protein kinase-dependent activation of K channels, which suggests that the final common pathway shared by NO and the nitrovasodilators is cGmp-dependent K-channel activation.
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Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases
Kazue Imai,K Nakachi +1 more
TL;DR: The inverse association between consumption of green tea and various serum markers shows that green tea may act protectively against cardiovascular disease and disorders of the liver.
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Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium.
Marianne Tare,Helena C. Parkington,Harold A. Coleman,T. O. Neild,Gregory J. Dusting,Gregory J. Dusting +5 more
TL;DR: It is reported that hyperpolarization and relaxation evoked by acetylcholine are reduced by NG-monomethyl-L-arginine, an inhibitor of NO biosynthesis from L-argInine, suggesting that NO derived from the endothelium can cause hyperPolarization of vascular smooth muscle, which might also contribute to relaxation by closing voltage-dependent calcium channels.
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Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats.
TL;DR: It is demonstrated that tea catechins exert a hypocholesterolemic effect in cholesterol-fed rats and increases fecal excretion of total lipids and cholesterol.