Journal ArticleDOI
Isolation, cloning, and expression of fatty-acid binding proteins from Fasciola gigantica
Reads0
Chats0
About:
This article is published in Experimental Parasitology.The article was published on 1997-01-01. It has received 32 citations till now. The article focuses on the topics: Fasciola gigantica & Fatty acid-binding protein.read more
Citations
More filters
Journal ArticleDOI
Progress in development of liver fluke vaccines.
Terry W. Spithill,John P. Dalton +1 more
TL;DR: The expectation of a commercially feasible vaccine that might also reduce parasite transmission in the field is now realistic, although major hurdles still exist, and the future prospects for vaccine development are discussed.
Journal ArticleDOI
Update on trematode infections in sheep
Francisco A. Rojo-Vázquez,Francisco A. Rojo-Vázquez,Aránzazu Meana,F. Valcárcel,María Martínez-Valladares +4 more
TL;DR: The manuscript concentrates on trematode species of veterinary importance for domestic sheep, which are found in the blood vessels of ruminants and are of minor importance in temperate regions.
Journal ArticleDOI
Evaluation of antigens of Fasciola gigantica as vaccines against tropical fasciolosis in cattle
S.Endah Estunningsih,Peter M. Smooker,Ening Wiedosari,S Widjajanti,Sam A. Vaiano,Sutijono Partoutomo,Terry W. Spithill +6 more
TL;DR: The protection observed in cattle vaccinated with native FABP of F. gigantica supports the notion that this class of proteins is a useful target for protection of animals against Fasciola and extends the efficacy of FABPs to the tropical liver fluke.
Journal ArticleDOI
Immunological approaches for the control of fasciolosis
TL;DR: Analysis of immune responses to Fasciola during infection in ruminants suggests that chronic infection correlates with a type 2 helper T cell response, implying that type 1 helpers T cell responses are down-regulated in fasciolosis.
Journal ArticleDOI
Humoral responses in mice following vaccination with DNA encoding glutathione S-transferase of Fasciola hepatica: effects of mode of vaccination and the cellular compartment of antigen expression.
TL;DR: The results demonstrate that the immunogenicity of a DNA vaccine based on Fasciola GST, as well as the isotype of the response against GST, is determined by the mode of vaccine administration.
References
More filters
Journal ArticleDOI
The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships.
David A. Sweetser,E H Birkenmeier,I J Klisak,S Zollman,R S Sparkes,T Mohandas,A J Lusis,Jeffrey I. Gordon +7 more
TL;DR: The nucleotide sequence of the gene encoding human I-FABP is determined and the primary structure of its protein product is defined and it is indicated that I-fABP mRNA is confined to the intestine.
Journal ArticleDOI
Treatment of immature and mature Fasciola hepatica infections in sheep with triclabendazole
TL;DR: A new benzimidazole anthelmintic, triclabendazole (CGA-89317) was found to be highly efficient against mature and early immature Fasciola hepatica infections in sheep.
Journal ArticleDOI
A Schistosoma mansoni fatty acid-binding protein, Sm14, is the potential basis of a dual-purpose anti-helminth vaccine
Miriam Tendler,C A Brito,Mônica Magno Vilar,N Serra-Freire,C M Diogo,Marta A. S. Almeida,Alexandre C. B. Delbem,J F Da Silva,Wilson Savino,Richard Charles Garratt,N Katz,A S Simpson +11 more
TL;DR: The results suggest that it may be possible to produce a single vaccine that would be effective against at least two parasites, F. hepatica and S. mansoni, of veterinary and human importance, respectively.
Journal ArticleDOI
Lipid metabolism in the parasitic and free-living flatworms, Schistosoma mansoni and Dugesia dorotocephala.
TL;DR: The composition and biosynthesis of fatty acids and complex lipids were examined in the parasitic blood fluke Schistosoma mansoni and the free-living planarian Dugesia dorotocephala, which have similar lipid patterns, although some quantitative differences exist.