Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease
Jean Soulier,Laurence Grollet,Eric Oksenhendler,Patrice Cacoub,Dominique Cazals-Hatem,Paul Babinet,Marie-Françoise D'Agay,Jean-Pierre Clauvel,Marline Raphael,Laurent Degos,François Sigaux +10 more
TLDR
Data suggest that KSHV could play a role in the pathogenesis of MCD, especially in HIV-infected patients, which is a close association with Kaposi's sarcoma.About:
This article is published in Blood.The article was published on 1995-08-15 and is currently open access. It has received 2121 citations till now. The article focuses on the topics: KSHV Inflammatory Cytokine Syndrome & Kaposi's sarcoma-associated herpesvirus.read more
Citations
More filters
Journal ArticleDOI
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture.
Rolf Renne,Weidong Zhong,Brian G. Herndier,Michael S. McGrath,Nancy W. Abbey,Dean H. Kedes,Don Ganem +6 more
TL;DR: The development of a system for the lytic growth of this virus in a latently infected B cell line and the first ultrastructural visualization of the virus are reported, which will facilitate the detailed study of the molecular biology of viral replication, the testing of antiviral drugs and the development of diagnostic tests for viral infection.
Journal ArticleDOI
Interleukin-6: from basic science to medicine--40 years in immunology.
TL;DR: This essay summarizes the 40 years of research in immunology that revealed the framework of cytokine signaling, including identification of the IL-6 receptor, gp130, NF-IL6, STAT3, and SOCS-1, but also led to the development of a new therapy for chronic inflammatory diseases.
Journal ArticleDOI
Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV
TL;DR: Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome.
Journal ArticleDOI
IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
TL;DR: Evidence that IL-6 trans-signaling is pro-inflammatory whereas classic IL- 6 signaling via the membrane bound IL-7R is needed for regenerative or anti-inflammatory activities of the cytokine is reviewed.
Journal ArticleDOI
The seroepidemiology of human herpesvirus 8 (kaposi’s sarcoma-associated herpesvirus): distribution of infection in ks risk groups and evidence for sexual transmission
TL;DR: The data support the inference that this virus is the etiologic cofactor predicted by the epidemiology of KS, and the distribution of HHV8 seropositivity conforms to that expected for a sexually transmitted pathogen and tracks closely with the risk for KS development.
References
More filters
Journal ArticleDOI
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
Yuan Chang,Ethel Cesarman,Melissa S. Pessin,Frank Lee,Janice Culpepper,Daniel M. Knowles,Patrick S. Moore +6 more
TL;DR: unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus.
Journal ArticleDOI
Kaposi's Sarcoma–Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity–Based Lymphomas
TL;DR: A high degree of conservation of KSHV sequences in Kaposi's sarcoma and in the eight lymphomas suggests the presence of the same agent in both lesions, suggesting that a novel herpesvirus has a pathogenic role in AIDS-related body-cavity-based lymphomas.
Journal ArticleDOI
Hyaline‐vascular and plasma‐cell types of giant lymph node hyperplasia of the mediastinum and other locations
TL;DR: Clinical signs and other data presented appear to favor an infectious or inflammatory etiology of giant lymph node hyperplasia, with most of the lesions being intrathoracic.
Journal ArticleDOI
Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and those without HIV infection.
Patrick S. Moore,Yuan Chang +1 more
TL;DR: The same herpesvirus-like DNA sequences are present in AIDS-associated Kaposi's sarcoma, classic Kaposi’s sarcomo, and the Kaposi' sarcoma that occurs in HIV-negative homosexual men, suggesting that all three are caused by the same infectious agent.
Journal ArticleDOI
Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection?
TL;DR: Kaposi's sarcoma in persons with AIDS may be caused by an as yet unidentified infectious agent, transmitted mainly by sexual contact.