Journal ArticleDOI
Kinetic resolution of ibuprofen catalyzed by Candida rugosa lipase in ionic liquids.
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TLDR
It was concluded that [BMIM]PF6 could be applied to substitute the conventional organic solvent (isooctane) in the esterification of ibuprofen.About:
This article is published in Chirality.The article was published on 2005-01-01. It has received 68 citations till now. The article focuses on the topics: Ionic liquid.read more
Citations
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Biocatalysis in ionic liquids
TL;DR: Roger Sheldon developed the concepts of E factors and atom utilization for assessing the environmental impact of chemical processes, particularly in relation to fine chemicals production.
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Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine.
TL;DR: The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems.
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Toward advanced ionic liquids. Polar, enzyme-friendly solvents for biocatalysis
TL;DR: This review covers selected examples of enzyme catalyzed reaction in ionic liquids that demonstrate their advantages and unique properties, and point out opportunities for new applications.
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Understanding Candida rugosa lipases: an overview.
TL;DR: In the present paper the recent developments published in the CRL field are overviewed, focusing on comparison of structural and biochemical data among isoenzymes (Lip1-Lip5), and their influence in the biocatalytical performance.
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Biocatalytic reactions in hydrophobic ionic liquids
TL;DR: The current review intends to address the important biotechnological applications of the frequently employed hydrophobic 1-butyl-3-methylimidazolium hexafluorophosphate ([Bmim] PF 6 ) IL and the comparison of various whole cell biocatalytic reactions using supercritical carbon dioxide (scCO 2 ) biphasic systems for product extraction with potentially competitive ILs and other conventional solvents.
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Journal ArticleDOI
Enzyme catalysis in ionic liquids.
TL;DR: Ionic liquids offer new possibilities for the application of solvent engineering to biocatalytic reactions, and in some cases, remarkable results with respect to yield, (enantio)selectivity or enzyme stability were observed.
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Lipase-Catalyzed Reactions in Ionic Liquids
TL;DR: Candida antarctica lipase was shown to catalyze alcoholysis, ammoniolysis, and perhydrolysis reactions using the ionic liquids 1-butyl-3-methylimidazolium tetrafluoroborate or hexafluorophosphate as reaction media.
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Biocatalysis in ionic liquids: markedly enhanced enantioselectivity of lipase.
TL;DR: Lipase-catalyzed transesterifications in ionic liquids proceeded with markedly enhanced enantioselectivity, and it was observed that lipases were up to 25 times more enantiosing than in conventional organic solvents.
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α‐Chymotrypsin catalysis in imidazolium‐based ionic liquids
TL;DR: In this paper, the transesterification reaction of N-acetyl-L-phenylalanine ethyl ester with 1-propanol catalyzed by α-chymotrypsin was examined in the ionic liquids 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) and 1-octyl- 3methylorinamide hexafloorophosphates ([omim]], and in combination with supercritical carbon dioxide (SC-CO2).
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Lipase-catalysed transesterification in ionic liquids and organic solvents: a comparative study
TL;DR: The influence of the ionic liquid as an additive in an organic solvent on this reaction has been demonstrated and the enzymes in ionic liquids in combination can be recycled for several runs without substantial diminution in the lipase activity.