Journal ArticleDOI
Kinetics of pharmacologic response.
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This article is published in Pharmacology & Therapeutics.The article was published on 1982-01-01. It has received 502 citations till now.read more
Citations
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Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models.
TL;DR: The design of rational dosing regimens for clinical therapeutics cannot be performed with a knowledge of pharmacokinelics alone, and the linking of pharmacokinetics and pharmacodynamics to predict firstly the dose-concentration, and then the concentration-effect relationship is required.
Journal ArticleDOI
Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor
Vincent J. Merluzzi,K. D. Hargrave,M. Labadia,Grozinger Karl G,Mark T. Skoog,Joe C. Wu,Cheng-Kon Shih,K. Eckner,S. Hattox,Julian Adams +9 more
TL;DR: Dipyridodiazepinones inhibition of HIV-1 replication in vitro as demonstrated by in situ hybridization, inhibition of protein p24 production, and the lack of syncytia formation in cultured human T cell lines and freshly isolated human peripheral blood lymphocytes.
Journal ArticleDOI
Chronic "brain death": meta-analysis and conceptual consequences.
TL;DR: The tendency to asystole in BD can be transient and is attributable more to systemic factors than to absence of brain function per se, which must be on some basis more plausible than loss of somatic integrative unity.
Journal ArticleDOI
Diversity of Mechanism-Based Pharmacodynamic Models
TL;DR: The purpose of this article is to describe the classic as well as contemporary approaches to pharmacodynamic modeling, with an emphasis on pertinent equations and salient model features.
Journal ArticleDOI
Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists.
Alan D. Michelson,Mark I. Furman,Pascal J. Goldschmidt-Clermont,Mary Ann Mascelli,Craig W. Hendrix,Lindsay D. Coleman,Jeanette D. Hamlington,Marc R. Barnard,Thomas S. Kickler,Douglas J. Christie,Sourav Kundu,Paul F. Bray +11 more
TL;DR: Pl(A2)-positive platelets displayed a lower threshold for activation, and platelets heterozygous for Pl(A) alleles showed increased sensitivity to 2 antiplatelet drugs, which may have relevance for in vivo thrombotic conditions.
References
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The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves
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Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine
TL;DR: A model of drug pharmacodynamic response that when integrated with a pharmacokinetic model allows characterization of the temporal aspects of pharmacodynamics as well as the time‐independent sensitivity component and can accommodate extremes of effect is proposed.
Journal ArticleDOI
Design of experiments in non-linear situations
George E. P. Box,H. L. Lucas +1 more
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Rational intravenous doses of theophylline.
TL;DR: Physiologic responses to intravenously administered theophylline were determined in nine hospitalized asthmatic subjects and continuous improvement in vital capacity and first-second forced expiratory volume was observed over the plasma range of theophyLLine concentration.