Journal ArticleDOI
Label-free biosensing based on single gold nanostars as plasmonic transducers.
Srujan Kumar Dondapati,Tapan K. Sau,Calin Hrelescu,Thomas A. Klar,Fernando D. Stefani,Jochen Feldmann +5 more
TLDR
Gold nanostars provide high sensitivity for single nanoparticle label-free biosensing and Streptavidin molecules are detected upon binding to individual, biotin-modified gold nanostar molecules by spectral shifts in the plasmon resonances.Abstract:
Gold nanostars provide high sensitivity for single nanoparticle label-free biosensing. The nanostars present multiple plasmon resonances of which the lower energy ones, corresponding to the nanostar tips and core−tip interactions, are the most sensitive to environmental changes. Streptavidin molecules are detected upon binding to individual, biotin-modified gold nanostars by spectral shifts in the plasmon resonances. Concentrations as low as 0.1 nM produce a shift of the tip related plasmon resonances of about 2.3 nm (5.3 meV).read more
Citations
More filters
Journal ArticleDOI
The golden age: gold nanoparticles for biomedicine
TL;DR: It is argued that gold nanotechnology-enabled biomedicine is not simply an act of 'gilding the (nanomedicinal) lily', but that a new 'Golden Age' of biomedical nanotechnology is truly upon us.
Journal ArticleDOI
Anisotropic gold nanoparticles: synthesis, properties, applications, and toxicity
TL;DR: The application of anisotropic AuNPs has rapidly spread to optical, biomedical, and catalytic areas, and a summary of the synthetic modes, variety of shapes, applications, and toxicity issues of this fast-growing class of nanomaterials is given.
Journal ArticleDOI
Optical detection of single non-absorbing molecules using the surface plasmon resonance of a gold nanorod.
TL;DR: The plasmonic detection of single molecules in real time without the need for labelling or amplification is reported, and the binding of single proteins is detected by monitoring the plAsmon resonance of the nanorod with a sensitive photothermal assay.
Journal ArticleDOI
Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging.
Hsiangkuo Yuan,Christopher G. Khoury,Hanjun Hwang,Christy Wilson,Gerald A. Grant,Tuan Vo-Dinh +5 more
TL;DR: A new, surfactant-free synthesis method of biocompatible gold nanostars with adjustable geometry such that the plasmon band can be tuned into the near-infrared region 'tissue diagnostic window', which is most suitable for in vivo imaging.
Journal ArticleDOI
Form Follows Function: Nanoparticle Shape and Its Implications for Nanomedicine.
Calum Kinnear,Thomas Moore,Laura Rodriguez-Lorenzo,Barbara Rothen-Rutishauser,Alke Petri-Fink +4 more
TL;DR: This review is a comprehensive description of the past decade of research into understanding how the geometry and size of nanoparticles affect their interaction with biological systems: from single cells to whole organisms.
References
More filters
Journal ArticleDOI
The Optical Properties of Metal Nanoparticles: The Influence of Size, Shape, and Dielectric Environment
TL;DR: In this paper, the authors describe recent progress in the theory of nanoparticle optical properties, particularly methods for solving Maxwell's equations for light scattering from particles of arbitrary shape in a complex environment.
Journal ArticleDOI
Gold and Silver Nanoparticles in Sensing and Imaging: Sensitivity of Plasmon Response to Size, Shape, and Metal Composition
TL;DR: This work investigated the dependence of the sensitivity of the surface plasmon resonance response to changes in their surrounding environment and the relative contribution of optical scattering to the total extinction, on the size and shape of nanorods and the type of metal, that is, Au vs Ag.
Journal ArticleDOI
Single Silver Nanoparticles as Real-Time Optical Sensors with Zeptomole Sensitivity
TL;DR: In this article, the authors demonstrate the localized surface plasmon resonance λmax response of individual Ag nanoparticles to the formation of a monolayer of small-molecule adsorbates.
Journal ArticleDOI
Drastic reduction of plasmon damping in gold nanorods.
Carsten Sönnichsen,Thomas Franzl,T. Wilk,G. von Plessen,Jochen Feldmann,Orla M. Wilson,Paul Mulvaney +6 more
TL;DR: In this paper, the dephasing of particle plasmons was investigated using light-scattering spectroscopy on individual gold nanoparticles, and a drastic reduction of the plasmon de-phasing rate in nanorods as compared to small nanospheres due to a suppression of interband damping was found.
Journal ArticleDOI
Shape- and size-dependent refractive index sensitivity of gold nanoparticles.
TL;DR: Gold nanoparticles of different shapes and sizes were dispersed into water-glycerol mixtures of varying volume ratios to investigate the response of their surface plasmon peaks to the refractive index of the surrounding medium.