Lack of Association of the Fat Mass and Obesity Associated (FTO) Gene rs9939609 Polymorphism with Breast Cancer Risk: a Systematic Review and Meta-Analysis Based on Case - Control Studies
Jamal Jafari-Nedooshan,Saeed Kargar,Hossein Neamatzadeh,Fatemeh Haghighi,reihaneh dehghani,Niloofar Seddighi +5 more
TLDR
This is the first meta-analysis of the FTO rs9939609 polymorphism and risk of breast cancer and suggested that only there might be a significant association of the CXCL12 rs1801157 polymorphisms with breast cancer risk.Abstract:
Background: Previously published data on any association of the fat mass and obesity-associated (FTO) gene with breast cancer risk remain inconclusive Therefore, we conducted the present meta-analysis of links between breast cancer and the FTO rs9939609 polymorphism Methods: We have conducted a systematic review of the English literature by searching PubMed, Google Scholar and ISI Web of Knowledge databases for studies on associations between the FTO rs9939609 polymorphism and breast cancer risk Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association using fixed- or random-effects model Results: We included five studies with 1134 cases and 1453 controls Overall, no significant association between the FTO rs9939609 polymorphism and risk of breast cancer was found On subgroup analysis by ethnicity, there was still no significant association detected Conclusions: To our knowledge, this is the first meta-analysis of the FTO rs9939609 polymorphism and risk of breast cancer However, the present meta-analysis suggested that only there might be a significant association of the CXCL12 rs1801157 polymorphisms with breast cancer riskread more
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m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.
TL;DR: It is shown that FTO, but not other m6A modification genes including METTL3, METTL14 and ALKBH5, was the major dysregulated factor responsible for aberrant m 6A modification in LUSC.
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The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers.
TL;DR: It was found that FTO single nucleotide polymorphisms (SNPs) were closely related with cancer risk and had great potential for clinical application by serving as a prognostic biomarker.
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Angiotensin Converting Enzyme Insertion/Deletion Polymorphism is Associated with Breast Cancer Risk: A Meta-Analysis
Mansour Moghimi,Saeed Kargar,Mohammadali Jafari,Hossein Ahrar,Mohammad Hossein Jarahzadeh,Hossein Neamatzadeh,Jalal Sadeghizadeh-Yazdi +6 more
TL;DR: It is suggested that ACE I/D polymorphism may be associated with increased risk of breast cancer, especially among Asian and Caucasians, however, well-designed studies with larger sample size and more ethnic groups are needed to further validate the results.
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Association of IL-10 rs1800871 and rs1800872 Polymorphisms with Breast Cancer Risk: A Systematic Review and Meta-Analysis
Mansour Moghimi,Hossein Ahrar,Mojgan Karimi-Zarchi,Kazem Aghili,Marjansadat Salari,Masoud Zare-Shehneh,Hossein Neamatzadeh +6 more
TL;DR: The results are inconsistent with previous meta-analysis suggests that IL-10rs1800871 and rs1800872 polymorphisms might contribute to BC susceptibility in overall population, but not by ethnicity.
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Association of GSTM1, GSTT1, GSTM3, and GSTP1 Genes Polymorphisms with Susceptibility to Osteosarcoma: a Case- Control Study and Meta-Analysis
Mansour Moghimi,Mohammad Reza Sobhan,Mohammad Hossein Jarahzadeh,Majid Morovati-Sharifabad,Kazem Aghili,Hossein Ahrar,Masoud Zare-Shehneh,Hossein Neamatzadeh +7 more
TL;DR: This meta-analysis demonstrated that GSTP1 and GSTT1 null genotype are associated with the risk of osteosarcoma.
References
More filters
Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
Journal ArticleDOI
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.
TL;DR: Current patterns of overweight and obesity in the United States could account for 14 percent of all deaths from cancer in men and 20 percent of those in women, and increased body weight was associated with increased death rates for all cancers combined and for cancers at multiple specific sites.
Book ChapterDOI
Breast Cancer Statistics
Jiemin Ma,Ahmedin Jemal +1 more
TL;DR: Breast cancer rates vary largely by race/ethnicity and socioeconomic status (SES), and geographic region, and death rates are higher in African American women than in whites, despite their lower incidence rates.
Journal ArticleDOI
Breast cancer statistics, 2013
TL;DR: An overview of female breast cancer statistics in the United States, including data on incidence, mortality, survival, and screening is provided, with African American women having the poorest breast cancer survival of any racial/ethnic group.
Journal ArticleDOI
The Medical Risks of Obesity
TL;DR: Evidence for significant associations of obesity with comorbidities is reviewed to provide information useful for optimal patient management to allow health care professionals to identify and implement appropriate interventions to reduce patient risk and mortality.