Learning of sensory sequences in cerebellar patients.
TLDR
Whether patients with cerebellar lesions are impaired in the acquisition and discrimination of sequences of sensory stimuli of different modalities is sought and sequence learning may be impaired only in tasks with significant motor demands.Abstract:
A possible role of the cerebellum in detecting and recognizing event sequences has been proposed The present study sought to determine whether patients with cerebellar lesions are impaired in the acquisition and discrimination of sequences of sensory stimuli of different modalities A group of 26 cerebellar patients and 26 controls matched for age, sex, handedness, musicality, and level of education were tested Auditory and visual sensory sequences were presented out of different sensory pattern categories (tones with different acoustic frequencies and durations, visual stimuli with different spatial locations and colors, sequential vision of irregular shapes) and different ranges of inter-cue time intervals (fast and slow) Motor requirements were small, with vocal responses and no time restrictions Perception of visual and acoustic stimuli was generally preserved in patients and controls The number of errors was significantly higher in the faster tempo of sequence presentation in learning of sequences of tones of different frequencies and in learning of sequences of visual stimuli of different spatial locations and different colors No difference in tempo between the groups was shown The total number of errors between the two groups was identical in the sequence conditions No major disturbances in acquisition or discrimination of various sensory sequences were observed in the group of cerebellar patients Sequence learning may be impaired only in tasks with significant motor demandsread more
Citations
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Consensus Paper: The Role of the Cerebellum in Perceptual Processes
Oliver Baumann,Ronald Borra,Ronald Borra,James M. Bower,Kathleen E. Cullen,Christophe Habas,Richard B. Ivry,Maria Leggio,Jason B. Mattingley,Marco Molinari,Eric A. Moulton,Michael G. Paulin,Marina A. Pavlova,Jeremy D. Schmahmann,Arseny A. Sokolov +14 more
TL;DR: This consensus paper summarizes the impressive empirical evidence on this problem and highlights diversities as well as commonalities between existing hypotheses into the influence of the cerebellum on sensory perception.
Journal ArticleDOI
The human cerebellum contributes to motor, emotional and cognitive associative learning. A review
Dagmar Timmann,J. Drepper,Markus Frings,Matthias Maschke,S. Richter,Marcus Gerwig,Florian P. Kolb +6 more
TL;DR: Human cerebellar lesion studies provide evidence that the cerebellum is involved in motor, emotional and cognitive associative learning and the posterolateral hemispheres appear to be of additional importance in fear conditioning in humans.
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The Cerebellar Cognitive Affective/Schmahmann Syndrome: a Task Force Paper
Georgios P. D. Argyropoulos,Kim van Dun,Michael Adamaszek,Maria Leggio,Mario Manto,Marcella Masciullo,Marco Molinari,Catherine J. Stoodley,Frank Van Overwalle,Richard B. Ivry,Jeremy D. Schmahmann +10 more
TL;DR: The paper substantiates the concept of CCAS with recent evidence from different scientific angles, promotes awareness of the CCAS as a clinical entity, and examines the current insight into the therapeutic options available.
Journal ArticleDOI
Cognitive sequencing impairment in patients with focal or atrophic cerebellar damage.
Maria Leggio,Anna Maria Tedesco,Francesca R. Chiricozzi,Silvia Clausi,A. Orsini,Marco Molinari +5 more
TL;DR: The present data support the hypothesis that sequence processing is the cerebellar mode of operation also in the cognitive domain and indicate that patients with cerebro-cerebellar damage present a cognitive sequencing impairment independently of lesion type or localization.
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Memory impairment, oxidative damage and apoptosis induced by space radiation: Ameliorative potential of α-lipoic acid
TL;DR: Results clearly indicate that alpha-lipoic acid is a potent neuroprotective antioxidant and support the idea suggesting the cerebellar involvement in cognition.
References
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Journal ArticleDOI
Ataxia reflected in the simulated movements of patients with cerebellar lesions.
TL;DR: The results showed that both movement times and mental-simulation times were greater for cerebellar patients than for control subjects under all experimental conditions, and the consequence of Cerebellar dysfunction on the time required to execute a volitional movement is reflected in the time needed to simulate the same behavior.
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Differences in trace and delay visuomotor associative learning in cerebellar patients.
Matthias Maschke,Johannes Drepper,Katja Bürgerhoff,Sandra Calabrese,Florian P. Kolb,Irene Daum,Hans-Christoph Diener,Dagmar Timmann +7 more
TL;DR: The lack of a better performance in the trace-condition compared to the delay-condition in cerebellar patients suggests deficits in learning the stimulus-response association.