Journal ArticleDOI
LEPR hypomethylation is significantly associated with gastric cancer in males.
Hang Yu,Ranran Pan,Yuanling Qi,Zhonghua Zheng,Jing Li,Hongxiang Li,Jieer Ying,Mingqing Xu,Shiwei Duan +8 more
TLDR
LEPR hypomethylation can be used to predict the risk of GC in males and it might also have the potential to Predict the recurrence in GC patients.About:
This article is published in Experimental and Molecular Pathology.The article was published on 2020-10-01. It has received 54 citations till now.read more
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Leptin and Cancer: Updated Functional Roles in Carcinogenesis, Therapeutic Niches, and Developments
Tsung-Chieh Lin,Michael Hsiao +1 more
TL;DR: In this article, a comprehensive analysis of leptin and leptin receptor distribution in a pancancer panel and in individual cell types of specific organs at the single-cell level is presented, identifying those sites that are prone to leptin-mediated tumorigenesis.
Journal ArticleDOI
Weighted gene co-expression network analysis identifies specific modules and hub genes related to coronary artery disease.
TL;DR: In this article, the authors used the Database for Annotation, Visualization and Integrated Discovery (DAVID) online tool to construct a protein-protein interaction (PPI) network, followed by the use of Molecular Complex Detection (MCODE) plug-ins in Cytoscape software to identify hub genes.
Journal ArticleDOI
Tumor size may influence the prognosis of solitary hepatocellular carcinoma patients with cirrhosis and without macrovascular invasion after hepatectomy.
TL;DR: In this article, the prognostic impact of tumor size on long-term outcomes after hepatectomy for solitary HCC patients with cirrhosis and without macrovascular invasion was investigated.
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DUNEScan: a web server for uncertainty estimation in skin cancer detection with deep neural networks
TL;DR: Deep Uncertainty Estimation for Skin Cancer (DUNEScan) as discussed by the authors is a web server that performs an intuitive in-depth analysis of uncertainty in commonly used skin cancer classification models based on CNNs.
Journal ArticleDOI
DUNEScan: a web server for uncertainty estimation in skin cancer detection with deep neural networks
TL;DR: Deep Uncertainty Estimation for Skin Cancer (DUNEScan) as discussed by the authors is a web server that performs an intuitive in-depth analysis of uncertainty in commonly used skin cancer classification models based on CNNs.
References
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Cancer statistics in China, 2015
Wanqing Chen,Rongshou Zheng,Peter D. Baade,Siwei Zhang,Hongmei Zeng,Freddie Bray,Ahmedin Jemal,Xue Qin Yu,Jie He +8 more
TL;DR: Many of the estimated cancer cases and deaths can be prevented through reducing the prevalence of risk factors, while increasing the effectiveness of clinical care delivery, particularly for those living in rural areas and in disadvantaged populations.
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Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.
TL;DR: Current patterns of overweight and obesity in the United States could account for 14 percent of all deaths from cancer in men and 20 percent of those in women, and increased body weight was associated with increased death rates for all cancers combined and for cancers at multiple specific sites.
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Abnormal splicing of the leptin receptor in diabetic mice
Gwo-Hwa Lee,Gwo-Hwa Lee,Ricardo Proenca,Ricardo Proenca,Jason M. Montez,K. M. Carroll,J. G. Darvishzadeh,Jaeeon Lee,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: A leptin receptor was recently cloned from choroid plexus and shown to map to the same 6-cM interval on mouse chromosome 4 as db8, suggesting that the weight-reducing effects of leptin may be mediated by signal transduction through a leptin receptor in the hypothalamus.
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Biological Action of Leptin as an Angiogenic Factor
M. Rocio Sierra-Honigmann,Anjali K. Nath,Chiaki Murakami,Guillermo García-Cardeña,Andreas Papapetropoulos,William C. Sessa,Lisa A. Madge,Jeffrey S. Schechner,Michael B. Schwabb,Peter J. Polverini,Jaime Flores-Riveros +10 more
TL;DR: It is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial cells, indicating that the vascular endothelium is a target for leptin and suggesting a physiological mechanism whereby leptin-induced angiogenesis may facilitate increased energy expenditure.
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Leptin: a review of its peripheral actions and interactions.
TL;DR: The complexity of the leptin axis indicates that it is unlikely that effective treatments for obesity will be simply derived, but improving knowledge and understanding of these complex interactions may point the way to the underlying physiology which predisposes some individuals to apparently unregulated weight gain.