Journal ArticleDOI
Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins
TLDR
Rolling of leukocytes on vascular endothelial cells, an early event in inflammation, can be reproduced in vitro on artificial lipid bilayers containing purified CD62, a selectin also named PADGEM and GMP-140 that is inducible on endothelial Cells.About:
This article is published in Cell.The article was published on 1991-05-31. It has received 2242 citations till now. The article focuses on the topics: Selectin & Cell adhesion.read more
Citations
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Integrins: versatility, modulation, and signaling in cell adhesion.
Journal ArticleDOI
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Journal ArticleDOI
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
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Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.
Ted Yednock,Catherine Cannon,Lawrence C. Fritz,Francisco Sánchez-Madrid,Lawrence Steinman,Nathan Karin +5 more
TL;DR: In vitro adhesion assay on tissue sections found that lymphocytes and monocytes bound selectively to inflamed EAE brain vessels, and therapies designed to interfere with α4βl integrin may be useful in treating inflammatory diseases of the central nervous system, such as multiple sclerosis.
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Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration
TL;DR: Recent findings show that the "traffic signals" for lymphocyte recirculation and for neutrophil and monocyte localization in inflammation are strikingly similar at the molecular level.
References
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Journal ArticleDOI
Adhesion receptors of the immune system.
TL;DR: Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responses.
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Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins
TL;DR: Endothelial leukocyte adhesion molecule-1 (ELAM-1), a cell surface glycoprotein expressed by cytokine-activated endothelium, mediates the adhesion of blood neutrophils and may be a member of a nascent gene family of cell surface molecules involved in the regulation of inflammatory and immunological events at the interface of vessel wall and blood.
Journal ArticleDOI
Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)
TL;DR: The purified ICAM-1 was incorporated into artificial supported lipid membranes and required metabolic energy production, an intact cytoskeleton, and the presence of Mg2+ and was temperature dependent, characteristics of LFA-1- and ICAM -1-dependent cell-cell adhesion.
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T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
TL;DR: It is shown that antigen-receptor cross-linking increases the strength of the adhesion mechan-ism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals trans-mitted from the T-cell antigen receptor to the LFA- 1 adhesion molecule.