Journal ArticleDOI
Adhesion receptors of the immune system.
TLDR
Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responses.Abstract:
The adhesive interactions of cells with other cells and with the extracellular matrix are crucial to all developmental processes, but have a central role in the functions of the immune system throughout life Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responsesread more
Citations
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Integrins: versatility, modulation, and signaling in cell adhesion.
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Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
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Cadherin cell adhesion receptors as a morphogenetic regulator
TL;DR: Cadherins are a family of cell adhesion receptors that are crucial for the mutual association of vertebrate cells and play a role in cell sorting mechanisms, conferring adhesion specificities on cells.
References
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Journal ArticleDOI
New perspectives in cell adhesion : RGD and integrins
TL;DR: Together, the adhesion proteins and their receptors constitute a versatile recognition system providing cells with anchorage, traction for migration, and signals for polarity, position, differentiation, and possibly growth.
Journal ArticleDOI
Integrins: a family of cell surface receptors.
TL;DR: This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.
Journal ArticleDOI
T-cell antigen receptor genes and T-cell recognition.
Mark M. Davis,Pamela J. Bjorkman +1 more
TL;DR: This view of T-cell recognition has implications for how the receptors might be selected in the thymus and how they (and immunoglobulins) may have arisen during evolution.
Journal Article
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
TL;DR: Staining of frozen sections and immunofluorescence flow cytometry showed intercellular adhesion molecule-1 (ICAM-1) is expressed on non-hematopoietic cells such as vascular endothelial cells, thymic epithel cells, certain other epithelial Cells, and fibroblasts, and on hematopOietic Cells such as tissue macrophages, mitogen-stimulated T lymphocyte blasts, and germinal center dendritic
Journal ArticleDOI
The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
Pamela J. Bjorkman,Pamela J. Bjorkman,Pamela J. Bjorkman,Mark A. Saper,Boudjéma Samraoui,W. S. Bennett,W. S. Bennett,Jack L. Strominger,Don C. Wiley +8 more
TL;DR: Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign antigens.