Journal ArticleDOI
Licoricidin, an isoflavonoid isolated from Glycyrrhiza uralensis Fisher, prevents UVA-induced photoaging of human dermal fibroblasts.
TLDR
The effects of licoricidin on photoaging of UVA‐irradiated human dermal fibroblasts (HDFs) are investigated by isolating the isoflavonoid isolated from Glycyrrhiza uralensis Fisher.Abstract:
Objective
Licoricidin is an isoflavonoid isolated from Glycyrrhiza uralensis Fisher. In this study, we investigated the effects of licoricidin on photoaging of UVA-irradiated human dermal fibroblasts (HDFs).
Methods
In vitro reactive oxygen species (ROS) scavenging activity, cellular protective effect and inhibition of elastase activity was determined by Fe3+-EDTA/H2O2 systems, photohaemolysis and elastase activity assay, respectively. Anti-oxidative capacity of the compound was evaluated by fluorescent ELISA and 2′, 7′-dichlorofluorescin-diacetate (DCF-DA) assay. The expression of protein and phosphorylation was examined using Western blot.
Results
The ROS scavenging activity (OSC50) of licoricidin was 2.77 μM. It was 3.1-fold higher than that of L-ascorbic acid. Its protective effects were confirmed in a study of 1O2-induced cellular damage to human erythrocytes. The τ50 value of 10 μM of licoricidin was 71.0 min; this was markedly higher than that obtained with α-tocopherol (37.0 min). The elastase inhibitory activity of licoricidin (IC50 of 61.2 μM) was 2.1-fold more potent than that of oleanolic acid. Licoricidin markedly reduced the UVA-induced intracellular ROS in a concentration-dependent manner. Western blot revealed that licoricidin attenuated the UVA-dependent induction of MMP-1 protein. Mechanistically, this appeared to be due to licoricidin-dependent inhibition of mitogen-activated protein kinases (MAPK) phosphorylation, which resulted in decreased c-Jun activation and reduced c-Jun and c-Fos expression.
Conclusion
Licoricidin blocks UVA-induced photoaging via ROS scavenging. This activity converges to limit the activity of MMP-1. These data suggest that licoricidin may be considered as an active ingredient in new topically applied anti-ageing formulations.read more
Citations
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The effect of dehydroglyasperin C on UVB–mediated MMPs expression in human HaCaT cells
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Skin photo-protection with phytochemicals against photo-oxidative stress, photo-carcinogenesis, signal transduction pathways and extracellular matrix remodeling-An overview.
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Gold Nanoparticles Using Ecklonia stolonifera Protect Human Dermal Fibroblasts from UVA-Induced Senescence through Inhibiting MMP-1 and MMP-3.
TL;DR: Findings indicate that the optimal ES-GNPs exerted an antisenescence effect on UVA-irradiated HDFs by inhibiting MMP-1/-3 expression, and posit that ES- GNPs may potentially be used to treat photoaging of the skin.
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Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis
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References
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Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?
Barry Halliwell,Matthew Whiteman +1 more
TL;DR: Methods used to trap RS, including spin trapping and aromatic hydroxylation, are critically examined, with a particular emphasis on those methods applicable to human studies and methods used to detect RS in cell culture.
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TL;DR: The results indicate a general sensitivity of proteins to oxygen radicals and indicate that proteins which have been denatured by .OH can be recognized and degraded rapidly and selectively by intracellular proteolytic systems.
Journal ArticleDOI
Mechanisms of photoaging and chronological skin aging
Gary J. Fisher,Sewon Kang,James Varani,Zsuzsanna Bata-Csorgo,Yinsheng Wan,Subhash C. Datta,John J. Voorhees +6 more
TL;DR: This article reviews the current understanding and presents new data about the molecular pathways that mediate skin damage by UV irradiation and by the passage of time and reveals that chronological aging and photoaging share fundamental molecular pathways.
Journal ArticleDOI
Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light
TL;DR: Multiple exposures to ultraviolet irradiation lead to sustained elevations of matrix metalloproteinases that degrade skin collagen and may contribute to photoaging.
Journal ArticleDOI
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Gary J. Fisher,Subhash C. Datta,Harvinder S. Talwar,Zeng Quan Wang,James Varani,Sewon Kang,John J. Voorhees +6 more
TL;DR: It is proposed that elevated metalloprotein-ases, resulting from activation of AP-1 and NF-KB by low-dose solar irradiation, degrade collagen and elastin in skin, which would result in solar scars, which through accumulation from a lifetime of repeated low- dose sunlight exposure could cause premature skin ageing (photoageing).