Journal ArticleDOI
Lipid Nanoparticles with a Solid Matrix (SLN®, NLC®, LDC®) for Oral Drug Delivery
TLDR
This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery using high-pressure homogenization production methods.Abstract:
Solid lipid nanoparticles (SLN®), nanostructured lipid carriers (NLC®), and lipid–drug conjugates (LDC®), commonly produced by high-pressure homogenization, are interesting vectors for oral delivery of lipophilic and, to a certain extent, hydrophilic substances. Their production can be done without the use of organic solvents. Techniques to make them a physically stable delivery system have been developed. Scaling up of the production process from lab-size to large-scale dimensions using high-pressure homogenization can be easily achieved by using a different type of homogenizer. The machines used for large-scale production often yield an even better product quality than the lab-scale types. This review article covers the methods of production, characterization, mechanisms of oral bioavailability enhancement, scale-up, final oral dosage forms, and regulatory aspects of lipid nanoparticles for oral drug delivery. It focuses mainly on high-pressure homogenization production methods.read more
Citations
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Journal ArticleDOI
Nanoparticles as drug delivery systems
TL;DR: Various nanostructures, including liposomes, polymers, dendrimers, silicon or carbon materials, and magnetic nanoparticles, have been tested as carriers in drug delivery systems and their connections with drugs are analyzed.
Journal ArticleDOI
Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application.
TL;DR: A wide discussion about preparation methods, advantages, disadvantages and applications of LNPs is presented by focusing on SLNs and NLCs, two major types of Lipid-based nanoparticles.
Journal ArticleDOI
Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery
Surajit Das,Anumita Chaudhury +1 more
TL;DR: In this article, a review of lipid nanoparticles based on solid matrix has been conducted to improve the oral bioavailability of several drugs, especially lipophilic compounds, and the stability of the formulations might increase than other liquid nano-carriers due to the solid matrix.
Journal ArticleDOI
Nanostructured lipid carriers: Promising drug delivery systems for future clinics.
Ana Beloqui,María Ángeles Solinís,Alicia Rodríguez-Gascón,António J. Almeida,Véronique Préat +4 more
TL;DR: The understanding of the nanostructured lipid carriers (NLC)-based formulations has improved with continuing research recently, and the result has seen an increase in the use of these in the clinical setting.
Journal ArticleDOI
Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs): Development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs?
TL;DR: NLCs demonstrated faster drug release than SLNs at low drug-loading, whereas there was no significant difference in drug release from SLNs and NLCs at high drug- loading, however, sustained/prolonged drug release was observed from both formulations.
References
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Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
Book
The Extra Pharmacopoeia
TL;DR: In this article, the authors present a directory of manufacturers of drugs and ancillary substances, including supplement drugs and other substances, as well as a list of manufacturers and suppliers.
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The extra pharmacopoeia
TL;DR: Part 1 Monographs on drugs and ancillary substances, Supplementary drugs and other substances, and Indexes - directory of manufacturers.
Journal ArticleDOI
Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems.
TL;DR: A simple classification system for lipid formulations, based on the polarity of the blend and reviewed here, will help comparison of data between laboratories and priorities for future work are discussed.
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