Journal ArticleDOI
Liver aldehyde and alcohol dehydrogenase activities in rat strains genetically selected for their ethanol preference.
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TLDR
It is concluded that the higher activities in the AA strain are due mainly to those aldehyde dehydrogenases of mitochondrial and microsomal fractions, which have K m -values for aldehydes in the millimolar range.About:
This article is published in Biochemical Pharmacology.The article was published on 1975-10-01. It has received 100 citations till now. The article focuses on the topics: Alcohol dehydrogenase & Acetaldehyde.read more
Citations
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The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)
TL;DR: AcH creates both unpleasant aversive reactions that protect against excessive alcohol drinking and euphoric sensations that may reinforce alcohol drinking, which will determine the overall behavioral and pathological developments.
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Relationship between facial flushing and blood acetaldehyde levels after alcohol intake.
Yasuhiko Mizoi,Iwao Ijiri,Yoshitsugu Tatsuno,Tetsuka Kijima,Satoshi Fujiwara,Junko Adachi,Shigeru Hishida +6 more
TL;DR: Increases of pulse rate, facial skin temperature and carotid arterial pressure and blood flow rate, as well as changes of digital plethysmogram and electrocardiogram, and elevation of blood acetaldehyde did not occur in the non-flushing group, but urinary excretions of epinephrine and norepinephrine increased in the flushing cases after the drinking.
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The distribution and metabolism of acetaldehyde in rats during ethanol oxidation-I. The distribution of acetaldehyde in liver, brain, blood and breath.
TL;DR: The results showed that the liver was the primary site for the oxidation of the ethanol-derived AeH, and only a small amount of the total AcH formed in this organ escaped into the rest of the body, but this amount increased with increased hepatic ethanol concentration.
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Role of acetaldehyde in the actions of ethanol on the brain--a review.
TL;DR: Future research needs to directly demonstrate in brain the formation of acetaldehyde in vivo, determine the concentrations in brain areas involved in ethanol consumption, and evaluate the possible actions of drugs other than an ability to block acetaldehyde metabolism.
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The role of acetaldehyde in the neurobehavioral effects of ethanol: a comprehensive review of animal studies.
TL;DR: It remains to be shown whether pharmacologically relevant concentrations of acetaldehyde are achieved in the brain after alcohol consumption in order to induce significant effects, and current evidence about the central mechanisms of action ofacetaldehyde is reviewed.
References
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Determination of serum proteins by means of the biuret reaction.
TL;DR: An investigation of the biochemical changes following experimental liver injury felt the need of a simple, rapid, and accurate method for determining the protein fractions in small amounts of serum and began with Kingsley’s biuret procedure.
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Biochemistry of dystrophic muscle. Mitochondrial succinate–tetrazolium reductase and adenosine triphosphatase
TL;DR: The discovery of a muscular dystrophy in a strain of mice has facilitated the search for biochemical alterations in myopathy and it seems probable that many, at least, of the secondary biochemical changes may be common to various types of muscle disease.
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Genetic selection for voluntary alcohol consumption in the albino rat.
TL;DR: By outbreeding Wistar rats and selecting for breeding animals that differ in their alcohol consumption, two genetically different lines are raised and marked differences between the sexes and the strains were evident by the eighth generation.
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The subcellular distribution and properties of aldehyde dehydrogenases in rat liver.
TL;DR: Kinetic experiments suggested the possible existence of at least two different NAD(+)-dependent aldehyde dehydrogenases in rat liver and distribution studies showed that one enzyme, designated enzyme I, was exclusively localized in the mitochondria and that another enzyme, designate enzyme II, was localized in both the mitochondia and the microsomal fraction.
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Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preference
TL;DR: A greater difference was found between the sexes, the female rats of both strains having a more rapid ethanol oxidation and oxygen consumption, compared with the respective males, and the AA strain displayed a significantly lower level of acetaldehyde during ethanol oxidation than did the ANA strain.