Showing papers in "Journal of Cardiac Failure in 1998"

TL;DR: In this paper, the effects of a continuous 4-hour infusion of human brain natriuretic peptide (hBNP) were determined in 16 decompensated heart failure patients in an invasive, randomized, double-blind, placebo-controlled study.

TL;DR: It is suggested that the improved function observed with beta blockers in heart failure could be due, in part, to a decrease in CPT-I activity and less fatty acid oxidation by the heart.

TL;DR: Exercise-based rehabilitation improves skeletal muscle capacity, exercise tolerance, and the health-related quality of life in women as well as in men with moderate, chronic heart failure.

TL;DR: The results suggest that mechanical stretch could evoke hypertrophic responses in cardiac myocytes that lack the AT1 signaling pathway possibly through tyrosine kinase activation.

TL;DR: NTG/NAC therapy is as effective as furosemide/morphine in the initial management of acute pulmonary edema, regardless of the presence or absence of respiratory failure, and the necessity for mechanical ventilatory assistance is infrequent in these patients, despite the initial medical treatment regimen.

TL;DR: Forearm exercise training improves endothelium-dependent vasodilation and peak hyperemic FBF in control subjects but not in patients with heart failure, suggesting that resistance vessel abnormalities may not be as readily modifiable by exercise training in patientswith heart failure compared with control subjects.

TL;DR: Hemodynamic pressure variables seem to be most consistently related (ie, inversely) to cognitive functioning among heart transplant candidates.

TL;DR: In this paper, the authors determined regional differences in patient characteristics and medication use among patients who entered into an international heart failure trial, and found significant regional variations in medication use, particularly with regard to digoxin, anticoagulants, and amiodarone.

TL;DR: This generally forgotten chapter in the history of cardiology was stimulated by reliance on the postmortem examination, which, until recently, had been the gold standard in clinical research to define mechanistic connections between pathological anatomy, clinical signs and symptoms, and hemodynamic abnormalities.

TL;DR: Compared to other ~-blockers, carvedilol may have a beneficial effect on renal hemodynamies via cq antagonism and appears to improve ~"~ (ml/mln) in contrast to the ~1 selective agent metoprolol.

TL;DR: Muscle performance is affected in terms of both strength and endurance, which might affect performance in everyday activities.

TL;DR: Consecutive screening and enrollment are feasible and offer a detailed description of the patient selection The consecutive principles contribute to representative patient samples and should be mandatory in future clinical trials.

TL;DR: The close relationship between capillary density and number of ACE transcripts indicate that activation of the renin-angiotensin system has an impact on capillary growth.

TL;DR: Chronic ACE inhibition therapy restored previously reduced IGF1 plasma levels in patients with CHF, most likely by reducing angiotensin II activity.

TL;DR: Left ventricular myocytes from failing hearts showed longer mean cell length compared with control hearts, and data from human right ventricle biopsy specimens confirmed the previous finding in rats that myocyte lengthening is less pronounced in this chamber in heart failure.

TL;DR: The rapid development and characterization of the various mouse models described in this article have provided meaningful new information on the molecular mechanisms underlying cardiac function and dysfunction and these models have lent valuable insights into genetic targets for treatment of heart disease.

TL;DR: The purpose of this study was to determine reproducibility in a steady state and to establish normal ranges of selected cardiac parameters, using ThoracicElectrical Bioimpedance (TEB) measurements in patients with known cardiovascular disease.

TL;DR: In summary, intravenous infusion of AM exerted diuresis and natriuresis without inducing hypotension and, in the higher dose, produced beneficial hemodynamic and renal vasodilator effects in rats with compensated HF.

TL;DR: Highened AT1 Ang II receptor activity occurred in this model of CHF, which contributed to alterations in systemic hemodynamics and vascular resistive properties and therefore may provide beneficial effects in a setting ofCHF.

TL;DR: Carvedilol is a useful additional therapy for patients with chronic heart failure already receiving amiodarone and can be added to amiodrone in these patients without expectation of increased adverse effects or loss of clinical efficacy.

TL;DR: Short-term GH given in sequence after chronic AT1 blockade had favorable actions on the failing heart and peripheral circulation by increasing LV wall thickness with partial reversal of unfavorable remodeling, lowering of vascular resistance, improvement of LV contractility, and enhanced LV systolic function and cardiac index relatively late after experimental MI.

TL;DR: The results suggest that the brain is a possible target for ACE inhibitors in the treatment of CHF after MI, and the dipsogenic response to centrally administered angiotensin is evaluated.

TL;DR: Preliminary nonrandomized trial data are currently available for each of these therapies with larger trials under way, and early results are intriguing and are yielding insights into these mechanisms.

TL;DR: Despite lack of persistent transgene expression in ventricular tissues, the high degree of transgenes expression achieved may be sufficient to allow evaluation of short-term effects of specific genetic manipulations in the heart.

TL;DR: It is postulated that partial suppression of myocardial fatty acid oxidation may be one mechanism underlying the beneficial effects of beta-adrenergic blocking agents on failing or remodeled hearts.

TL;DR: Mild vasoconstrictor infusions of A-II do not increase regional NE spillover in the forearm circulation of patients with CHF and the beta-adrenergic agonist ISO does increase regional spillover, but the effect seems to be primarily related to flow rather than presynaptic stimulation of NE release.