Journal ArticleDOI
Long Noncoding RNA Sponges miR-454 to Promote Osteogenic Differentiation in Maxillary Sinus Membrane Stem Cells
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TLDR
In-depth analyses showed that lncRNA-MODR acts as a molecular sponge for microRNA-454 (miR-454) and that prevents RUNX2 from mi-454-mediated suppression and thus promotes osteogenesis of MSMSCs.Abstract:
Objective:Although increasing evidence has shown that long noncoding RNAs (lncRNAs) play an important regulatory role in pluripotency and differentiation of mesenchymal stem cells, little is known about the role of lncRNA in maxillary sinus membrane stem cells (MSMSCs). The goal of this study was toread more
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Mesenchymal stem cell-associated lncRNA in osteogenic differentiation
TL;DR: Research concerning lncRNA in osteogenic differentiation of MSCs is reviewed and the importance of lncRNAs in bone formation and bone regeneration is highlighted.
Journal ArticleDOI
An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells.
TL;DR: The roles and molecular mechanism of lncRNAs including H19, MALAT1, MODR, HOTAIR, DANCR, MEG3, HoxA-AS3, and MIAT in osteogenesis ossification, and lncRNA ZBED3-AS1 and CTA-941F9.9 will facilitate the development and application of novel molecular drugs which regulate the balance of bone formation and absorption.
Journal ArticleDOI
Hsa_circRNA_33287 promotes the osteogenic differentiation of maxillary sinus membrane stem cells via miR-214-3p/Runx3.
TL;DR: The novel pathway circRNA_33287/miR-214-3p/Runx3 was found to play a role in regulating the osteoblastic differentiation of MSMSCs in the posterior maxilla and was shown to increase ectopic bone formation in vivo.
Journal ArticleDOI
Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells
Carmen Lanzillotti,Monica De Mattei,Chiara Mazziotta,Francesca Taraballi,John Charles Rotondo,Mauro Tognon,Fernanda Martini +6 more
TL;DR: In this article, the authors described the recent discoveries on lncRNA-miRNA crosstalk during the osteogenic differentiation of mesenchymal stem cells (MSCs) derived from bone marrow (BM), as well as from different other anatomical regions.
Journal ArticleDOI
Long noncoding RNAs: a missing link in osteoporosis
Andreia M. Silva,Sara Reis Moura,José H. Teixeira,Mário A. Barbosa,Susana G. Santos,Maria Inês Almeida +5 more
TL;DR: The role of lncRNAs in bone cell differentiation, metabolism and fracture healing is explored - and early studies assessing their role as diagnostic and prognostic biomarkers of osteoporosis are described.
References
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MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship
TL;DR: This work has shown that targets can reciprocally control the level and function of miRNAs, and this has important implications for the use of these RNAs in therapeutic settings.
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Endogenous miRNA Sponge lincRNA-RoR Regulates Oct4, Nanog, and Sox2 in Human Embryonic Stem Cell Self-Renewal
Yue Wang,Zhenyu Xu,Junfeng Jiang,Chen Xu,Jiuhong Kang,Lei Xiao,Minjuan Wu,Jun Xiong,Xiaocan Guo,Houqi Liu +9 more
TL;DR: It is demonstrated that a lincRNA, linc-RoR, may function as a key competing endogenous RNA to link the network of miRNAs and core TFs, e.g., Oct4, Sox2, and Nanog, and suggested that linc -RoR forms a feedback loop with coreTFs and miRNA-response elements to regulate ESC maintenance and differentiation.
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Role and regulation of RUNX2 in osteogenesis.
TL;DR: The regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed and the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked.
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Runx2: Structure, function, and phosphorylation in osteoblast differentiation
TL;DR: The structural integrity of Runx2 and its posttranslational modifications, especially the phosphorylation responsible for either stimulation or inhibition of its regulatory role in osteogenesis are summarized.
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MicroRNA biogenesis: Regulating the Regulators
TL;DR: The basic steps of miRNA biogenesis are reviewed and the various factors that control miRNA transcription, processing, and stability in animal cells are described.