Journal ArticleDOI
Long-term reproducibility of positive patch test reactions in patients with non-immediate cutaneous adverse drug reactions to antibiotics.
Reads0
Chats0
TLDR
As in contact allergy, T cell‐mediated hypersensitivity in non‐immediate (NI) cutaneous adverse drug reactions (CADRs) to antibiotics is considered to be lifelong, but, in this setting, patch tests have rarely been repeated after long time intervals.Abstract:
SummaryBackground
As in contact allergy, T cell-mediated hypersensitivity in non-immediate (NI) cutaneous adverse drug reactions (CADRs) to antibiotics is considered to be lifelong, but, in this setting, patch tests have rarely been repeated after long time intervals.
Objective
To evaluate the long-term reproducibility of positive patch test reactions to antibiotics in patients with NI CADRs.
Methods
Fifty-six patients with NI CADRs to antibiotics who had relevant positive reactions during patch testing were invited to repeat patch tests with a similar antibiotic series 2–15 years thereafter.
Results
Twenty patients were included (9 males and 11 females; mean age 54.6 years): 18 with maculopapular exanthema, 1 with drug hypersensitivity syndrome, and 1 with acute generalized exanthematous pustulosis. Results were reproducible in 17 of 20 patients after a mean interval of 6.0 years (range 2–14.7 years). Concerning β-lactams, 7 of 8 patients remained positive for aminopenicillins, 4 of 4 for isoxazolyl penicillins, and 1 for cefoxitin. Patch test results were also reproducible for clindamycin in 5 of 7 patients, for vancomycin in 1 patient, and for spiramycin in 1 patient. Reproducibility was not affected by the time interval between tests, sex, or age at testing.
Conclusions
In the context of NI CADRs, we showed high reproducibility of positive patch test reactions to various antibiotics, even after several years.read more
Citations
More filters
Journal ArticleDOI
The Combined Utility of Ex Vivo IFN-γ Release Enzyme-Linked ImmunoSpot Assay and In Vivo Skin Testing in Patients with Antibiotic-Associated Severe Cutaneous Adverse Reactions.
Jason A Trubiano,K. Strautins,Alec J. Redwood,Rebecca Pavlos,Katherine C. Konvinse,Ar Kar Aung,Monica A. Slavin,Karin A Thursky,M Lindsay Grayson,Elizabeth J. Phillips,Elizabeth J. Phillips +10 more
TL;DR: The potential utility of combined in vivo and ex-vivo testing in patients with AA-SCARs to assign drug causality with high specificity is demonstrated.
Journal ArticleDOI
Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics
Gerda Wurpts,Werner Aberer,Heinrich Dickel,Randolf Brehler,Thilo Jakob,Burkhard Kreft,Vera Mahler,Vera Mahler,Hans F. Merk,Norbert Mülleneisen,Hagen Ott,Wolfgang Pfützner,Stefani Röseler,Franziska Ruëff,Helmut Sitter,Cord Sunderkötter,Axel Trautmann,Regina Treudler,Bettina Wedi,Margitta Worm,Knut Brockow +20 more
TL;DR: This guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology and the Paul-Ehrlich Society for Chemotherapy in a consensus procedure according to the criteria of the German Association of Scientific Medical Societies.
Journal ArticleDOI
Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) in collaboration with the German Society of Allergology (AeDA), German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Contact Dermatitis Research Group (DKG), the Austrian Society for Allergology and Immunology (ÖGAI), and the Paul-Ehrlich Society for Chemotherapy (PEG).
Gerda Wurpts,Werner Aberer,Heinrich Dickel,Randolf Brehler,Thilo Jakob,Burkhard Kreft,Vera Mahler,Hans F. Merk,Norbert Mülleneisen,Hagen Ott,Wolfgang Pfützner,Stefani Röseler,Franziska Ruëff,Helmut Sitter,Cord Sunderkötter,Axel Trautmann,Regina Treudler,Bettina Wedi,Margitta Worm,Knut Brockow +19 more
TL;DR: This guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology and the Paul-Ehrlich Society for Chemotherapy in a consensus procedure according to the criteria of the German Association of Scientific Medical Societies.
Journal ArticleDOI
Delabeling Delayed Drug Hypersensitivity: How Far Can You Safely Go?
Rannakoe J. Lehloenya,Jonny Peter,Ana Copascu,Jason A Trubiano,Elizabeth J. Phillips,Elizabeth J. Phillips +5 more
TL;DR: The decision to use a drug challenge as a diagnostic or delabeling tool in a patient with a severe delayed IM-ADR should weigh the risk-benefit ratio, balancing the severity and priority for the treatment of the underlying, and the availability of alternative efficacious and safe treatments.
Journal ArticleDOI
Non-immediate Cutaneous Reactions to Beta-Lactams: Approach to Diagnosis.
TL;DR: Patch tests are a simple and safe diagnostic tool, which in the case of severe reactions should be used as the first line of investigation, however, patch tests are less sensitive than intradermal tests, which are preferable in subjects with mild reactions.
References
More filters
Journal ArticleDOI
European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice
Jeanne D. Johansen,Kristiina Aalto-Korte,Tove Agner,Klaus Ejner Andersen,Andreas J. Bircher,Magnus Bruze,Alicia Cannavó,Ana Giménez-Arnau,Margarida Gonçalo,An Goossens,Swen M. John,Carola Lidén,Magnus Lindberg,Vera Mahler,Mihály Matura,Thomas Rustemeyer,Jørgen Serup,Radoslaw Spiewak,Jacob P. Thyssen,M. Vigan,Ian R. White,Mark Wilkinson,Wolfgang Uter +22 more
TL;DR: The present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed‐type hypersensitivity skin and mucosal conditions.
Journal ArticleDOI
Drug allergy: an updated practice parameter.
TL;DR: Predictable reactions are subdivided into drug intolerance, drug idiosyncrasy, drug allergy, and pseudoallergic reactions, which are estimated to comprise approximately 80% of all ADRs.
Journal ArticleDOI
General considerations for skin test procedures in the diagnosis of drug hypersensitivity
TL;DR: This poster presents a poster presented at the European Congress of Allergy and Clinical Immunology/Allergology, entitled “Evaluating the immune defences of the immune system against fungal infections”.
Journal ArticleDOI
Skin test concentrations for systemically administered drugs -- an ENDA/EAACI Drug Allergy Interest Group position paper
Knut Brockow,Lh Garvey,Werner Aberer,Marina Atanaskovic-Markovic,A. Barbaud,M. B. Bilò,Andreas J. Bircher,Miguel Blanca,B Bonadonna,Paolo Campi,E Castro,Jr Cernadas,Am Chiriac,Pascal Demoly,Martine Grosber,J Gooi,Carla Lombardo,Pm Mertes,Holger Mosbech,S Nasser,M. Pagani,J. Ring,Audrey Romano,Kathrin Scherer,B Schnyder,S. Testi,María José Torres,Axel Trautmann,Ingrid Terreehorst +28 more
TL;DR: This work has performed a literature search on skin test drug concentration in MEDLINE and EMBASE, reviewed and evaluated the literature in five languages using the GRADE system for quality of evidence and strength of recommendation, and recommends drug concentration for skin testing aiming to achieve a specificity of at least 95%.
Journal ArticleDOI
Diagnosis of nonimmediate reactions to beta-lactam antibiotics.
Antonino Romano,Miguel Blanca,M.J. Torres,Andreas J. Bircher,Werner Aberer,Knut Brockow,Werner J. Pichler,Pascal Demoly +7 more
TL;DR: Clinical and immunohistological studies and analysis of drug‐specific T‐cell clones obtained from the circulating blood and the skin suggest that a type‐IV (cell‐mediated) pathogenic mechanism may be involved in some nonimmediate reactions such as maculopapular or bullous rashes and acute generalized exanthematous pustulosis.
Related Papers (5)
European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice
Jeanne D. Johansen,Kristiina Aalto-Korte,Tove Agner,Klaus Ejner Andersen,Andreas J. Bircher,Magnus Bruze,Alicia Cannavó,Ana Giménez-Arnau,Margarida Gonçalo,An Goossens,Swen M. John,Carola Lidén,Magnus Lindberg,Vera Mahler,Mihály Matura,Thomas Rustemeyer,Jørgen Serup,Radoslaw Spiewak,Jacob P. Thyssen,M. Vigan,Ian R. White,Mark Wilkinson,Wolfgang Uter +22 more