Showing papers in "The Journal of Allergy and Clinical Immunology: In Practice in 2017"

TL;DR: The rarity of fatal anaphylaxis and the significant quality- life impact of allergic conditions suggest that quality of life impairment should be a key consideration when making treatment decisions in patients at risk for anAPHylaxis.

TL;DR: Specific inhaler errors have been identified as critical errors, evidenced by frequency and association with asthma outcomes, and Asthma management should target inhaler training to reduce key critical errors.

TL;DR: This work will review common inciting factors for asthma exacerbations and approaches to prevent and treat these events, particularly with human rhinovirus.

TL;DR: Compared with children with nonsevere asthma, children with severe asthma had more symptoms and more historical exacerbations, but no difference in body weight, post-bronchodilator lung function, or inflammatory markers.

TL;DR: Obesity is detrimental to lung function, but specific patterns differ between children and adults, and weight control should be considered in the management of airway disease among the obese.

TL;DR: AERD is common among patients with CRSwNP; even though patients with AERD have C RSwNP and asthma, the clinical course of their disease is not the same as of patients who have CRS w NP and asthma but are tolerant to COX-1 inhibitors.

TL;DR: Compared with placebo, AR101 significantly reduced symptom severity during exit DBPCFCs and modulated peanut-specific cellular and humoral immune responses and demonstrated clinical activity as a potential immunomodulatory treatment option in peanut-allergic children over the age of 4, adolescents, and young adults.

TL;DR: The severity of AR symptoms was the most consistent disease-related factor associated with a greater impact of AR on work productivity, although ocular symptoms and sleep disturbances may independently affect work productivity.

TL;DR: A steering committee of AD experts, including dermatologists, allergists, and a patient advocacy group representative, developed recommendations on the basis of a literature review and expert opinion to help clinicians understand how new therapies fit into the current treatment paradigm and to provide practical recommendations for assessing AD severity, treatment response, and treatment failure.

TL;DR: A 5-day oral challenge without preceding ST is safe and sufficient to exclude penicillin allergy after NIR developing duringPenicillin treatment, and mild reactions to the home challenge regardless of their ST results.

TL;DR: Penicillin allergy testing using a physician-pharmacist team model effectively removes reported allergies in hospitalized patients and substantially reduces unnecessary inpatient and outpatient use of beta-lactam alternatives that may otherwise go unaddressed.

TL;DR: In patients with moderate-to-severe eosinophilic asthma, intravenous reslizumab 3.0 mg/kg displays favorable long-term safety and sustained long- term efficacy.

TL;DR: A proportion of people living with common variable immunodeficiency disorders develop granulomatous-lymphocytic interstitial lung disease (GLILD), and a consensus statement on the definition, diagnosis, and management of GLILD was developed.

TL;DR: The safety of oral amoxicillin challenge without preceding PCN skin testing in Marine recruits at MCRD is determined and it is suggested that oral challenge alone may be a suitable method of evaluation, particularly in patients who had nonimmediate cutaneous reactions.

TL;DR: A proposed modification of the 2010 WAO SAR grading system is presented that will make it applicable to all SARs due to any cause, and allows for classification of less severe SARs, which may be underreported or overreported in clinical trials and surveillance studies, depending on the criteria specified for adverse event reporting.

TL;DR: Allergen-specific strategies currently explored for the treatment of food allergy are discussed, including immunotherapy with native and heat-modified food proteins and modifications of allergen structure and addition of immunomodulatory adjuvants.

TL;DR: Rates of ED visits for anaphylaxis increased in all age groups, but the greatest increase was in children aged 5 to 17 years (196% increase; P < .001), and the rate of food-related and medication-related ED visits increased by 212% and 212% respectively between 2005 and 2014.

TL;DR: Because of the potential detrimental adverse effects of corticosteroids and lack of compelling evidence demonstrating an effective role in reducing anaphylaxis severity or preventing biphasic anAPHylaxis, the authors do not advocate for their routine use in anphylaxis.

TL;DR: The basic and clinical science of SCAR diagnosis and management is updated and strong HLA-gene associations have been elucidated for specific drug-SCAR IM-ADRs such as Stevens-Johnson syndrome/toxic epidermal necrolysis.

TL;DR: This review highlights the clinical asthma phenotypes identified to date, their associations with underlying endotypes and potential biomarkers, and remaining knowledge gaps that must be addressed before precision medicine can become a reality for patients with severe asthma.

TL;DR: The Australian Infant Feeding Summit achieved national consensus on the wording of guidelines for infant feeding and allergy prevention in a context in which there is a high prevalence of food allergy.

TL;DR: Almost all patients with an immediate HSR can be safely re-exposed either through desensitization or challenge depending on the severity and mechanism of the initial reaction, as shown for cetuximab.

TL;DR: Using TDABC, penicillin allergy evaluation costs $220; even with varied assumptions adjusting for operational challenges, clinical setting, and expanded testing,Penicillin allergies evaluation still costs only about $540, which may be offset for patients treated with costly alternative antibiotics.

TL;DR: A clinical association between IgE-mediated food allergy and EoE has implications for the management of children with food allergy, and particular relevance to patients undergoing OIT.

TL;DR: Having demonstrated efficacy in severe asthma, the antibodies have been tested in proof-of-concept studies in patients with nasal polyposis with or without asthma, and have demonstrated their potential to reduce nasal and sinus nasal polyp burden monitored by nasal endoscopy and computed tomography scanning, and to improve typical symptoms.

TL;DR: FA phenotypes and health care utilization differ among children of different racial and/or ethnic backgrounds in the United States that put AA and Hispanic children at higher risks of adverse outcome than white children.

TL;DR: Penicillin allergy testing, primarily done in the setting of an outpatient Allergy consultation, was associated with significantly less health care utilization during 3.6+ years of follow-up and greater use of narrow-spectrum antibiotics.

TL;DR: Different factors can modulate the likelihood of IgE-mediated food allergy of a given allergy test result, namely, the patients' age, ethnicity, previous allergic reaction to the identified food, concomitant atopic conditions, and geographical location, and need to be taken into account when interpreting the allergy test results in the clinic.

TL;DR: CsA is effective at low to moderate doses in chronic spontaneous urticaria and adverse events appear to be dose dependent and occur in more than half the patients treated with moderate doses of CsA.

TL;DR: The statement below is not to be construed as dictating an exclusive course of action nor is it intended to replace the medical judgment of healthcare professionals.